Chitosan oligosaccharide/alginate nanoparticles as an effective carrier for astaxanthin with improving stability, in vitro oral bioaccessibility, and bioavailability

Sorasitthiyanukarn, Feuangthit Niyamissara; Muangnoi, Chawanphat; Rojsitthisak, Pornchai

doi:10.1016/j.foodhyd.2021.107246

Cited by 53 publications

(13 citation statements)

References 78 publications

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“…Alternatively, Maity et al [69] have prepared naringenin-loaded alginate-coated chitosan core-shell NPs (Figure 4) that could effectively deliver the flavonoid and reduce the glycemia of tested animals without raising toxicity concerns. Other emerging applications of CANPs-based oral delivery systems include improving solubility and therapeutic effects of antilipidemic drugs [85], protecting against oxidative stress [72,73], potentiating the treatment of obesity, cardiovascular diseases [86], and multiple sclerosis [87], and enhancing the bioavailability of active compounds in functional foods, nutraceuticals, and dietary supplements [88]. Other emerging applications of CANPs-based oral delivery systems include improving solubility and therapeutic effects of antilipidemic drugs [85], protecting against oxidative stress [72,73], potentiating the treatment of obesity, cardiovascular diseases [86], and multiple sclerosis [87], and enhancing the bioavailability of active compounds in functional foods, nutraceuticals, and dietary supplements [88].…”

Section: Oral Deliverymentioning

confidence: 99%

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Niculescu

Grumezescu

2022

Nanomaterials

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Chitosan and alginate are two of the most studied natural polymers that have attracted interest for multiple uses in their nano form. The biomedical field is one of the domains benefiting the most from the development of nanotechnology, as increasing research interest has been oriented to developing chitosan-alginate biocompatible delivery vehicles, antimicrobial agents, and vaccine adjuvants. Moreover, these nanomaterials of natural origin have also become appealing for environmental protection (e.g., water treatment, environmental-friendly fertilizers, herbicides, and pesticides) and the food industry. In this respect, the present paper aims to discuss some of the newest applications of chitosan-alginate-based nanomaterials and serve as an inception point for further research in the field.

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Section: Oral Deliverymentioning

confidence: 99%

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Niculescu

Grumezescu

2022

Nanomaterials

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“…Various labs, including ours [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ], have shown that chitosan is capable of encapsulating various types of therapeutic agents such as small molecule drugs to exploratory biologicals such as proteins and even DNA in delivery platforms of various sizes. As chitosan can even be ingested with no complications, this fact further cements the usefulness of this biopolymer in drug delivery R&D. Chitosan NPs have been formulated in the past using various methods, not limited to complex coacervation [ 64 ] and ionotropic gelation [ 65 ], both simple enough to carry out in most labs.…”

Section: Chitosan—a Promising Biopolymer That Has Potential In Athero...mentioning

confidence: 99%

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Sriamornsak

Dass

2022

Pharmaceutics

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Chitosan is a natural biopolymer that is present in an abundant supply in sources such as crustacean shells, mushrooms, and insect exoskeletons. It can be used to make a variety of types of drug formulations and is generally safe to use in vivo; plus, it has inherent cholesterol-reducing properties. While an abundance of papers has tested this biopolymer in nanoparticles in cancer and diabetes research, there is a lag of usage, and hence the paucity of information, in the area of cardiovascular research, specifically in atherosclerosis, the topic of this review. This review highlights some of the deficiencies in this niche area of research, examines the range of chitosan nanoparticles that have been researched to date, and proposes several ways forward to advance this field. Nanoparticles used for both diagnostic and therapeutic purposes are reviewed, with a discussion on how these nanoparticles could be better researched in future and what lays ahead as the field potentially moves towards clinical trials in future.

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“…CS is a biopolymer with potential for oral or mucosal delivery of macromolecules, such as polypeptides, proteins, and polysaccharides. It has many advantages in drug delivery including mucoadhesion [ 26 , 39 ], enhanced penetration [ 34 , 35 , 36 , 37 ], and improved oral absorption [ 30 , 31 ]. It has also been used in the preparation of nanoparticles to control drug release and protect active compounds from enzymatic degradation and destruction by gastric acid [ 21 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…The mucoadhesive properties allow CS NPs to easily attach to the mucus layer [ 26 , 33 ], thereby enhancing the gastrointestinal tract (GIT) residence time. Furthermore, the positive charges on CS NPs can transiently open tight junctions between epithelial cells to enhance drug permeation across the intestinal epithelium [ 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanoparticles Prepared from Chitosan and Casein for Delivery of Bioactive Polysaccharides

et al. 2022

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Ophiopogon japonicus polysaccharides (OJPs) have great anti-inflammation and immunomodulatory abilities. However, the low bioavailability of OJPs reduces its applicability in the biomedical and pharmaceutical fields. Chitosan (CS) has excellent mucoadhesive properties and absorption-enhancing ability in oral administration. Casein hydrolysate (CL) has good interfacial diffusivity and emulsifying ability, and can interact with polysaccharides to form complexes combining the individual properties of both. Therefore, chitosan and casein hydrolysate are good candidates for developing nanoformulations for oral delivery. In this study, bioactive polysaccharides (OJPs), CS and CL, were combined to prepare CS/OJPs/CL co-assembled biodegradable nanoparticles. The interactions between polysaccharides (CS and OJPs) and peptide (CL) resulted in the formation of nanoparticles with an average particle size of 198 nm and high OJPs loading efficiency. The colloidal properties of the nanoparticles were pH-dependent, which were changed significantly in simulated digestive fluid at different pH values. OJPs released from the CS/OJPs/CL nanoparticles were greatly affected by pH and enzymatic degradation (trypsin and lysozyme). The nanoparticles were easily internalized by macrophages, thereby enhancing the OJPs’ inhibitory ability against Ni2+-induced cytotoxicity and LPS-induced nitric oxide production. This study demonstrates that prepared polysaccharide/protein co-assembled nanoparticles can be potential nanocarriers for the oral delivery of bioactive polysaccharides with anti-inflammatory functions.

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Chitosan oligosaccharide/alginate nanoparticles as an effective carrier for astaxanthin with improving stability, in vitro oral bioaccessibility, and bioavailability

Cited by 53 publications

References 78 publications

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Biodegradable Nanoparticles Prepared from Chitosan and Casein for Delivery of Bioactive Polysaccharides

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