Chitosan-oleic acid-sodium alginate a hybrid nanocarrier as an efficient delivery system for enhancement of lutein stability and bioavailability

Toragall, Veeresh; Jayapala, Naveen; Baskaran, Vallikannan

doi:10.1016/j.ijbiomac.2020.02.104

Cited by 68 publications

(37 citation statements)

References 59 publications

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“…The lutein loaded nanocarrier (LNCs) system was prepared by the ionotropic gelation method (Farshid & Lakshmi, 2017) with modi cation (Toragall, Jayapala, & Vallikannan, 2020). In brief, chitosan (1 mg/mL) was dissolved in 0.1% acetic acid solution.…”

Section: Preparation Of Nanocarrier System By Ionic Gelation Methodsmentioning

confidence: 99%

“…The carotenoids rich hexane phase was collected, pooled, concentrated, and loaded onto an activated silica column (60•120 mesh). A mixture of dichloromethane: methanol (1:1, v/v) was used to elute lutein and its purity was con rmed by high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) (Lakshminarayana, Raju, Prakash, & Baskaran, 2009;Toragall, Jayapala, & Vallikannan, 2020).…”

Section: Puri Cation Of Luteinmentioning

confidence: 99%

“…Micellar (control) and LNCs lutein concentration was determined as per (Toragall, Jayapala, & Vallikannan, 2020). In brief, 1mL of LNCs or mixed micelles was extracted for lutein and con rmed the purity by HPLC prior to intubation to animals.…”

Section: Dosingmentioning

confidence: 99%

“…(150 µM for 2h) induced oxidative stress condition as evidenced in diabetes in cells and processed for lutein extraction and analysed by HPLC (Lakshminarayana et , 2009;Toragall, Jayapala, & Vallikannan, 2020).…”

Section: Cellular Lutein Uptakementioning

confidence: 99%

“…We have also reported characteristic features and the safety of chitosan-alginate-oleic acid-based nanocarrier system (Toragall, Jayapala, & Vallikannan, 2020).…”

Section: Introductionmentioning

confidence: 96%

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Chitosan-sodium alginate-fatty acid nanocarrier composite: lutein bioavailability, absorption pharmacokinetics in diabetic rat and protection of retinal cells against H2O2 induced oxidative stress in vitro

Toragall

Baskarn

2020

Preprint

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Aiming to enhance therapeutic efficiency of lutein, lutein loaded chitosan-sodium alginate (CS-SA) based nanocarrier composite (LNCs) were prepared and evaluated for lutein bioavailability and pharmacokinetics in diabetic rats in comparison to micellar lutein (control). Further, cytotoxicity, cellular uptake and protective activity against H2O2 induced oxidative stress in ARPE-19 cells were studied. Results revealed that LNCs displayed maximal lutein AUC in plasma, liver and eye respectively in normal (3.1, 2.7 and 5.2 folds) and diabetic (7.3, 3.4 and 2.8 folds) rats. Lutein from LNCs exhibited a higher half-life time, mean residence time and slow clearance from the plasma, indicating prolonged circulation compared to control. In ARPE-19 cells, pre-treatment with LNCs (10 µM) have significantly attenuated H2O2 induced cell death, intracellular ROS and mitochondrial membrane potential compared to control. In conclusion, LNCs improve the lutein bioavailability in conditions like diabetes, diabetic retinopathy and cataract to curtail oxidative stress in retinal cells.

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Section: Preparation Of Nanocarrier System By Ionic Gelation Methodsmentioning

confidence: 99%

Section: Puri Cation Of Luteinmentioning

confidence: 99%

Section: Dosingmentioning

confidence: 99%

Section: Cellular Lutein Uptakementioning

confidence: 99%

“…We have also reported characteristic features and the safety of chitosan-alginate-oleic acid-based nanocarrier system (Toragall, Jayapala, & Vallikannan, 2020).…”

Section: Introductionmentioning

confidence: 96%

See 3 more Smart Citations

Chitosan-sodium alginate-fatty acid nanocarrier composite: lutein bioavailability, absorption pharmacokinetics in diabetic rat and protection of retinal cells against H2O2 induced oxidative stress in vitro

Toragall

Baskarn

2020

Preprint

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An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Dodero

Alberti

Gaggero

et al. 2021

Adv Materials Inter

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along with other polysaccharides (e.g., celluloses, chitosan, etc.), is indeed considered an extremely promising material in the viewpoint of circular economy and in substituting petroleum-derived polymers. [3] Among others, one of the reasons for alginate success is its unique capability to bind different cations leading to stable and tailor-made hydrogels. [4] Owing to its biocompatibility, biodegradability, and nontoxicity, in the past decades alginate has been vastly explored for drug and gene delivery, tissue engineering, and wound healing applications. [5] In this sense, the recent nanotechnological advances have allowed the fabrication and exploitation of alginate-based nanostructured materials with completely new capabilities. Thereby, it is not surprising that nowadays a broad variety of alginate-based nanomaterials with various shapes, sizes, and compositions are prepared via different approaches, including controlled gelation, electrospinning and electrospraying, self-assembly, phase-separation, and micro fluidics., All these nanostructures hold the potential to interact with living organisms much more efficiently with respect to bulk systems, hence leading to specific functionalities at the same time avoiding the occurrence of toxicity issues. [6][7][8] Despite the use of alginate-based nanomaterials has been reviewed in the past, the focus has been commonly pointed to their generic properties and applications. Conversely, this review attempts to provide a more specific and comprehensive summary limited to the most recent advances in the fabrication and use of two of the most common and promising alginatebased nanomaterials, namely nanoparticles (NPs) and electrospun nanofibers (NFs), with a focus on biomedical and pharmaceutical applications.

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Novel radioiodinated desvenlafaxine‐loaded lipid nanocapsule for brain delivery

Ayoub,

Abdel‐Mottaleb,

Ibrahem

et al. 2023

Archiv der Pharmazie

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Lipid nanocapsules (LNCs) are lipid nanocarriers developed for drug delivery enhancement. The antidepressant drug desvenlafaxine (DSV) was entrapped in LNC to improve its brain delivery. Different DSV‐loaded LNCs formulae using different oils and surfactants were studied to obtain the optimum formula for further studies. In vivo biodistribution studies were done using Swiss albino mice by intravenous injection of DSV‐loaded LNCs by radioiodination technique. The optimum DSV‐loaded LNC formula was obtained by using Labrafil® M1944CS as the oil and Solutol® HS15 as the surfactant in the ratio of 1:1, with a particle size of 34.28 ± 0.41 nm, a polydispersity index of 0.032 ± 0.05, a zeta potential of −25.77 ± 1.41, and good stability for up to 6 months. The in vivo biodistribution and pharmacokinetics data ensure the bioavailability improvement for DSV brain delivery as Cmax and AUC(1–t) increased more than double for intravenously DSV‐loaded LNCs compared with the DSV solution. In conclusion, the results obtained from this study give an insight into the great potential of using DSV‐loaded LNC for the enhancement of brain delivery.

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Chitosan-oleic acid-sodium alginate a hybrid nanocarrier as an efficient delivery system for enhancement of lutein stability and bioavailability

Cited by 68 publications

References 59 publications

Chitosan-sodium alginate-fatty acid nanocarrier composite: lutein bioavailability, absorption pharmacokinetics in diabetic rat and protection of retinal cells against H2O2 induced oxidative stress in vitro

Chitosan-sodium alginate-fatty acid nanocarrier composite: lutein bioavailability, absorption pharmacokinetics in diabetic rat and protection of retinal cells against H2O2 induced oxidative stress in vitro

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Novel radioiodinated desvenlafaxine‐loaded lipid nanocapsule for brain delivery

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