Chitosan nanopolymers: An overview of drug delivery against cancer

Shanmuganathan, Rajasree; Edison, Thomas Nesakumar Jebakumar Immanuel; LewisOscar, Felix; Kumar, Ponnuchamy; Shanmugam, Sabarathinam; Pugazhendhi, Arivalagan

doi:10.1016/j.ijbiomac.2019.02.060

Cited by 185 publications

(96 citation statements)

References 103 publications

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“…7 Moreover, evidence has demonstrated the link between oxidative stress and cancer development. 8 One of the challenges in cancer treatment is finding a method of diagnosis and treatment that is effective and target specific. 8 This represents a major drawback in the diagnosis and treatment of cancer and other diseases and has led to the development of nanomedicine an area of nanotechnology involving the manipulation of matter within the nanoscale range of 1-100 nm at 10 −9 dimension.…”

Section: Introductionmentioning

confidence: 99%

“…8 One of the challenges in cancer treatment is finding a method of diagnosis and treatment that is effective and target specific. 8 This represents a major drawback in the diagnosis and treatment of cancer and other diseases and has led to the development of nanomedicine an area of nanotechnology involving the manipulation of matter within the nanoscale range of 1-100 nm at 10 −9 dimension. 9 The medical applications of nanotechnology involve the use of both chemical and physical methods for the synthesis of organic and inorganic nanoparticles that are biocompatible for transporting drugs with high target specificity.…”

Section: Introductionmentioning

confidence: 99%

“…9 The medical applications of nanotechnology involve the use of both chemical and physical methods for the synthesis of organic and inorganic nanoparticles that are biocompatible for transporting drugs with high target specificity. 8 Nanoparticles are capable of improving drug permeation across cell membranes 10 and controlling the release of the encapsulated drug. 9 Chitosan is currently being explored due to its unique properties as a nanocarrier for the delivery of antimicrobial, anticancer and antioxidative agents of natural origin, such as plant essential oils (EOs).…”

Section: Introductionmentioning

confidence: 99%

“…9 Chitosan is currently being explored due to its unique properties as a nanocarrier for the delivery of antimicrobial, anticancer and antioxidative agents of natural origin, such as plant essential oils (EOs). [8][9][10][11] Ocimum gratissimum (OG) is a herbaceous plant belonging to the Lamiaceae family. This plant is indigenous to tropical, savanna and coastal areas.…”

Section: Introductionmentioning

confidence: 99%

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Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of Ocimum Gratissimum Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity

Onyebuchi¹,

Kavaz²

2019

IJN

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Background: The encapsulation of plant essential oils (EOs) with polymeric materials (e.g. chitosan (CS) and N, N, N-trimethyl chitosan (TMC)) and the further reduction of the polymers into their nano sizes are gaining research interest in nanotechnology due to potential applications in medical drug delivery systems as well as the food and pharmaceutical industry. The present study reports a novel approach for the synthesis of Ocimum gratissimum essential oil (OGEO)-loaded CS and TMC nanoparticles with distinct bioactive and physiochemical properties. Methods: The OGEO-loaded CS and TMC nanoparticles were characterised using various microscopic and spectroscopic techniques. The bioactive compounds in Ocimum gratissimum methanolic extract (OG-MeOH) and EOs was evinced with gas chromatography-mass spectrometry (GC-MS). Total phenolic content (TPC) of OGEO and OG-MeOH was determined using the Folin-Ciocalteu method. The in vitro drug release kinetic pattern was ascertained by membrane dialysis, while antioxidant activity was determined by the 2,2-diphenyl-1picrylhydrozyl (DPPH) free radical scavenging method. The disc diffusion method was used for antibacterial activity evaluation, while MTT and a trypan blue dye exclusion assay were used to assess cytotoxic activity on MDA-MB-231 breast cancer cells. Results: GC-MS analysis revealed components that have not been previously reported for Ocimum gratissimum. The maximum OGEO cumulative drug release percentage in vitro was observed at pH 3 for both OGEO-loaded chitosan nanoparticles (OGEO-CSNPs) and OGEOloaded N, N, N-trimethyl chitosan nanoparticles (OGEO-TMCNPs). The antioxidant activity of OGEO-CSNPs and OGEO-TMCNPs never reached a steady state after 75 h. OGEO-TMCNPs exhibited antibacterial activity at a lower concentration for both Gram-negative and Gram-positive food pathogens. In vitro cytotoxicity revealed the increased toxicity of OGEO-TMCNPs on MDA-MB-231 breast cancer cell lines. Conclusion: OGEO-loaded CS and TMC nanoparticles were synthesised using a novel material optimisation approach. The synthesised nanoparticles have shown a promising application in the pharmaceutical and food industries.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of Ocimum Gratissimum Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity

Onyebuchi¹,

Kavaz²

2019

IJN

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“…116 From the metallic nanoparticles, AgNPs are the most popular choice as anti-infectious nanoparticle-adjuvants. 17 In conjunction with appropriate-drug delivery systems as chitosan 117 AgNP per se or in combination with proanthocyanidin shown also a good in vitro antitumoral effect, against HT 29 human adenocarcinoma cells. 118,119 The antibacterial properties of AgNP, their mechanism of action and especially their antimycobacterial effects will be further detailed.…”

Section: Persistence Of Viable Mycobacteria In Dead Cells and Necrotimentioning

confidence: 99%

Silver Nanoparticles for the Therapy of Tuberculosis

Tabaran

Matea²,

Mocan³

et al. 2020

IJN

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Rapid emergence of aggressive, multidrug-resistant Mycobacteria strain represents the main cause of the current antimycobacterial-drug crisis and status of tuberculosis (TB) as a major global health problem. The relatively low-output of newly approved antibiotics contributes to the current orientation of research towards alternative antibacterial molecules such as advanced materials. Nanotechnology and nanoparticle research offers several exciting new-concepts and strategies which may prove to be valuable tools in improving the TB therapy. A new paradigm in antituberculous therapy using silver nanoparticles has the potential to overcome the medical limitations imposed in TB treatment by the drug resistance which is commonly reported for most of the current organic antibiotics. There is no doubt that AgNPs are promising future therapeutics for the medication of mycobacterial-induced diseases but the viability of this complementary strategy depends on overcoming several critical therapeutic issues as, poor delivery, variable intramacrophagic antimycobacterial efficiency, and residual toxicity. In this paper, we provide an overview of the pathology of mycobacterial-induced diseases, andhighlight the advantages and limitations of silver nanoparticles (AgNPs) in TB treatment.

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Chitosan‐Based Nanoparticles for Drug Delivery

Rostami¹

2021

Nanoengineering of Biomaterials

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Chitosan nanopolymers: An overview of drug delivery against cancer

Cited by 185 publications

References 103 publications

<p>Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of <em>Ocimum Gratissimum</em> Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity</p>

<p>Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of <em>Ocimum Gratissimum</em> Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity</p>

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Chitosan‐Based Nanoparticles for Drug Delivery

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