Chitosan Nanoparticles Potentiate the in vitro and in vivo Effects of Curcumin and other Natural Compounds

Abstract

: The development of biodegradable nanoparticles is an important tool for the biological transport of chemical compounds. The nanoencapsulation reduces the biopharmaceutical and pharmacokinetic drawbacks of compounds and enhances their biological properties. Naturally occurring polymers such as proteins and polysaccharides have been widely applied in the development of nanostructured systems of several therapeutic agents. Among them is chitosan, a crustaceancarapace-chitin derived biopolymer. In addition to its biocompatibility and biodegradability, chitosan is known for its mucoadhesion properties. Chitosan-based nanostructured systems potentiate most of aspects of the loaded drugs, including cellular transport and other biological effects. The use of chitosan nanoparticles enhances permeation, stability, and bioactivity of natural compounds. In this review, an overview of the main features of chitosan nanoparticles that improved in vitro and in vivo effects of bioactive natural molecules is given, emphasizing the results obtained with curcumin.

Salix subserrata Bark Extract-Loaded Chitosan Nanoparticles Attenuate Neurotoxicity Induced by Sodium Arsenate in Rats in Relation with HPLC–PDA-ESI–MS/MS Profile

“…Nanotechnology was utilized to increase the solubility and efficacy of natural plants. Chitosan is a widely used polymer in drug delivery compounds with an acceptable safety profile [13][14][15]. Although some research has been carried out on gold nanoparticle synthesis using the bark and leave extract of Salix alba [16,17], no one reports the synthesis of nanoparticles using S. subserrata stem bark extract.…”

Repositioned Natural Compounds and Nanoformulations: A Promising Combination to Counteract Cell Damage and Inflammation in Respiratory Viral Infections

“…In recent years, the study of the therapeutic benefits of natural bioactive substance-based nanomedicine in the treatment of various diseases, including respiratory viral infections, has attracted more and more attention [ 129 , 130 , 131 , 132 , 133 , 134 , 135 ]. These pathologies are characterized by acute or chronic inflammatory processes and high oxidative stress in which medicine based on nanotechnology and natural compound association seems to have a promising future [ 91 ].…”

Nanopartículas sólidas lipídicas e sua aplicação na entrega de compostos ativos naturais / Solid lipidic nanoparticles and their application in the delivery of natural active compounds

“…In O desenvolvimento humano e tecnológico trouxe para essa década desafios que demandam modificações na forma de se fazer pesquisa e desenvolver produtos e tecnologia (SAHOO et al, 2020). Há um interesse crescente por métodos que sejam cada vez mais biodegradáveis e sustentáveis (LOPES et al, 2020). Nesse sentido, a indústria farmacêutica tem passado por essas novas demandas, e com isso surgem as alternativas "verdes" também chamadas de "green chemical", substituindo o uso de solventes tóxicos ao meio ambiente por produtos biocompatíveis e biodegradáveis (CRAWFORD et al, 2017;MONDAL et al, 2020), e incentivando processos com menos etapas e com geração de menos resíduos, consequentemente reduzindo o impacto ambiental (ULLAH et al, 2020).…”