Chitosan nanoparticles as a potential drug delivery system attached to viscose cellulose fibers

Ristić, Tijana; Zabret, Andrej; Zemljič, Lidija Fras; Peršin, Zdenka

doi:10.1007/s10570-016-1125-5

Cited by 25 publications

(26 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are already some studies reporting the use of differently prepared chitosan-based particles for drug encapsulation, whereas their EE using Equation (1) varies a lot. For example, Ristić et al [33] showed an 87% EE of clindamycin 2-phospate incorporated into chitosan nanoparticles. Previously, tenofovir in a mixture of water and ethanol rendered EE of around 6%, whereas their optimal conditions for drug encapsulation, led to an EE of 20% [29].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology

et al. 2019

View full text Add to dashboard Cite

Silicones are widely used medical materials that are also applied for tympanostomy tubes with a trending goal to functionalise the surface of the latter to enhance the healing of ear inflammations and other ear diseases, where such medical care is required. This study focuses on silicone surface treatment with various antimicrobial coatings. Polysaccharide coatings in the form of chitosan nanoparticles alone, or with an embedded drug mixture composed of amoxicillin/clavulanic acid (co-amoxiclav) were prepared and applied onto silicone material. Plasma activation was also used as a pre-treatment for activation of the material’s surface for better adhesion of the coatings. The size of the nanoparticles was measured using the DLS method (Dynamic Light Scattering), stability of the dispersion was determined with zeta potential measurements, whilst the physicochemical properties of functionalised silicone materials were examined using the UV-Vis method (Ultraviolet-Visible Spectroscopy), SEM (Scanning Electron Microscopy), XPS (X-Ray Photoelectron Spectroscopy). Moreover, in vitro drug release testing was used to follow the desorption kinetics and antimicrobial properties were tested by a bacterial cell count reduction assay using the standard gram-positive bacteria Staphylococcus aureus. The results show silicone materials as suitable materials for tympanostomy tubes, with the coating developed in this study showing excellent antimicrobial and biofilm inhibition properties. This implies a potential for better healing of ear inflammation, making the newly developed approach for the preparation of functionalised tympanostomy tubes promising for further testing towards clinical applications.

show abstract

Section: Resultsmentioning

confidence: 99%

“…[10,29,31,32]. Moreover, chitosan nanoparticles were also used successfully as a delivery system for iodine and drugs previously attached onto cellulose medical textiles [33,34].…”

Section: Introductionmentioning

confidence: 99%

Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology

et al. 2019

View full text Add to dashboard Cite

show abstract

“…38 It has been already discussed that the antimicrobial properties of chitosan are more antibacterial than antifungal. 39 From our results, it may be remarked that only the polyethylene foils coated with 30% of pullulan and further with a layer of 1% of chitosan macromolecular solution improved, to some extent (32% R), the antimicrobial activity against A. flavus.…”

Section: Concentration (Mass Concentration)mentioning

confidence: 57%

Pullulan-Chitosan Coatings Onto Polyethylene Foils for the Development of Active Packaging Material

Zemljič¹,

Ulrih²,

Sterniša³

et al. 2019

Cellulose Chem. Technol.

View full text Add to dashboard Cite

Polyethylene (PE) material in the form of foils as conventional packaging material was functionalised with polysaccharide pullulan and an additional layer of chitosan macromolecular solution. In this study, the best concentration of pullulan (10%, 20% or 30%) was determined with the objective of improving the barrier properties of conventional PE food packaging material. As additional layer, a chitosan macromolecular solution was adsorbed to the material in order to endow it with antimicrobial activity. In this way, a functional composite material was developed, which can find potential application as active packaging, to offer prolonged shelf-life to packaged food. The functionalized PE material was analysed from the physico-chemical point of view (gravimetric analysis, goniometry, FTIR spectroscopy, standard test for oxygen permeability, SEM analysis). Moreover, antimicrobial testing of the foils was done and the desorption of both polysaccharides from the PE surface was evaluated. The latter properties are essential when evaluating the practical value of active packaging.

show abstract

“…An insufficient anti-microbial activity (AATCC standard 147) on Staphylococcus aureus is seen with all functionalized samples (no zone of inhibition). However, not only antimicrobial properties are essential for medical textiles development, but also antioxidant activity [18][19]. Functionalization of viscose with combination of psyllium and the horsetail extract proved to be more effective if compared to viscose, functionalized with combination of protein colloid (keratin) in combination with the horsetail extract.…”

Section: Resultsmentioning

confidence: 99%

Textile cosmetic pads based on psyllium and protein colloid in combination with the horsetail extract

et al. 2019

View full text Add to dashboard Cite

The basic purpose of this research work was to develop a care/healing cosmetic pads where a horsetail water extract was selected as a healing/care compound. Together with this, psyllium and keratin (protein colloid) were used as natural compounds capable to form a gel-like structure in aqueous media, so they were explored as i) carriers of a care/healing compound (horsetail extract), and as ii) “binding element” (due to relatively high viscosity) in-between the healing compound and the textile substrate (i.e. non-woven viscose) itself. Such functionalization system was relatively easily applied onto the non-woven viscose substrate. In this way the final product i.e. the cosmetic pad was created showing good ant oxidative activity, storage stability and biodegradability. The latest is extremely important for environmentally friendly products.

show abstract

Chitosan nanoparticles as a potential drug delivery system attached to viscose cellulose fibers

Cited by 25 publications

References 37 publications

Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology

Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology

Pullulan-Chitosan Coatings Onto Polyethylene Foils for the Development of Active Packaging Material

Textile cosmetic pads based on psyllium and protein colloid in combination with the horsetail extract

Contact Info

Product

Resources

About