Chitosan nanocomposites with CdSe/ZnS quantum dots and porphyrin

Sewid, F. A.; Annas, Kirill; Dubavik, Aliaksei; Вениаминов, А. В.; Маслов, В. Г.; Orlov, Alexei O.

doi:10.1039/d1ra08148a

Cited by 11 publications

(17 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MCD spectra of QDs comprise two opposite-signed symmetrical bands, centered at 667 nm and 682 nm due to Zeeman splitting of the Q-band, due to degenerate state caused by the high symmetry of the molecule [ 39 ]. Data on magnetic circular dichroism indicate the absence of aggregates in sample solutions, since a comparative analysis of the spectral curves of pure PS with conjugates does not show any changes in the shapes of the spectra themselves according to identification of bands in the MCD spectrum in work [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

New Conjugates Based on AIS/ZnS Quantum Dots and Aluminum Phthalocyanine Photosensitizer: Synthesis, Properties and Some Perspectives

et al. 2022

View full text Add to dashboard Cite

Today, fluorescent diagnostics and photodynamic therapy are promising methods for diagnosing and treating oncological diseases. The development of new photosensitizers (PS) is one of the most important tasks to improve the efficiency of both laser-induced diagnostics and therapy. In our study, we conjugated PS with AIS/ZnS triple quantum dots (QDs) to obtain non-aggregated complexes. It was shown that the conjugation of PS with QDs does not change the PS fluorescence lifetime, which is a marker of the preservation of PS photophysical properties. In particular, efficient resonant Förster energy transfer (FRET), from QDs to PS molecules in the conjugate, increases the PS luminescence response. The FRET from QD to PS molecules with different ratios of donor and acceptors are shown. It has been demonstrated that the average efficiency of FRET depends on the ratio of PS and QD and reaches a maximum value of 80% at a ratio of 6 PS molecules per 1 QD molecule. Thus, these studies could help to contribute to the development of new complexes based on QD and PS to improve the efficiency of phototheranostics.

show abstract

Section: Resultsmentioning

confidence: 99%

New Conjugates Based on AIS/ZnS Quantum Dots and Aluminum Phthalocyanine Photosensitizer: Synthesis, Properties and Some Perspectives

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In this regard, QDs can be used as effective drug carries for traditional PS to combat solubility and aggregation issues. Moreover, QDs can enhance the fluorescence emission of the photosensitizer drug by FRET interactions by several folds ( Sewid et al, 2022 ). Suitable QD-PS conjugates are synthesized such that the QD emission overlaps with the PS excitation, thereby allowing the excitation of PS at lower wavelengths, as well as enhanced fluorescence emission by the PS.…”

Section: Semiconductor Quantum Dotsmentioning

confidence: 99%

Semiconductor quantum dots for photodynamic therapy: Recent advances

Uprety

Abrahamse

2022

Front. Chem.

View full text Add to dashboard Cite

Photodynamic therapy is a promising cancer treatment that induces apoptosis as a result of the interactions between light and a photosensitizing drug. Lately, the emergence of biocompatible nanoparticles has revolutionized the prospects of photodynamic therapy (PDT) in clinical trials. Consequently, a lot of research is now being focused on developing non-toxic, biocompatible nanoparticle-based photosensitizers for effective cancer treatments using PDT. In this regard, semiconducting quantum dots have shown encouraging results. Quantum dots are artificial semiconducting nanocrystals with distinct chemical and physical properties. Their optical properties can be fine-tuned by varying their size, which usually ranges from 1 to 10 nm. They present many advantages over conventional photosensitizers, mainly their emission properties can be manipulated within the near IR region as opposed to the visible region by the former. Consequently, low intensity light can be used to penetrate deeper tissues owing to low scattering in the near IR region. Recently, successful reports on imaging and PDT of cancer using carbon (carbon, graphene based) and metallic (Cd based) based quantum dots are promising. This review aims to summarize the development and the status quo of quantum dots for cancer treatment.

show abstract

“…Quantum dots (QDs) are a new type of ultrasmall condensed matter particles that have drawn highly fundamental and applied interest as potential vehicles for photodynamic therapy. Their characteristic optoelectronic properties, owing to the quantum confinement in individual QDs, leading to novel exciton generation and recombination in the intrabandgap, provided remarkably relevant energy/electron transfer features for optical applications. ,,, For instance, QDs are potential sensitizers, individually ,,− or together with organic photosensitizers ,− ,− as surface carriers for singlet molecular oxygen ( 1 O 2 ) generation. The mechanistic approach toward the sensitization of singlet oxygen generation by QDs, involving energy transfer and migration between the sensitizer and molecular oxygen, is a challenging task.…”

Section: Fundamental Optoelectronic Properties Of Qdsmentioning

confidence: 99%

“…The type of energy transfer mechanism depends on the alignment between the conduction band (CB) of QDs and the singlet state of molecules in a donor–acceptor system. If the position of the singlet excited state of the molecular acceptor is below and close to the CB of QDs, the energy transfer can occur either by Förster energy transfer (FRET) or Dexter energy transfer (DET) to create a singlet excited state acceptor. ,,− , On the other hand, TET is a preferred pathway if the singlet excited state of molecules lies above the CB of QDs . However, long-range dipole-based FRET, short-range DET, and electron transfer are considered dominant nonradiative pathways to transfer singlet energy in donor–acceptor (D–A) systems.…”

Section: Design and Mechanism Of Qds Energy Transfermentioning

confidence: 99%

“…Semiconductor QDs have been shown to be highly efficient sensitizers for 1 O 2 production either individually or functionalized with other inorganic materials or molecular sensitizers. ,,− Individually, QDs can be light activated to produce 1 O 2 via triplet energy transfer (TET) ,− or charge transfer ,,, or energy transfer from dopant defects to dioxygen. On the other hand, QDs functionalized with molecular acceptors involve QDs energy transfer to a molecular acceptor which subsequently sensitizes 1 O 2 production. ,− ,− Thus, QDs offers distinct advantages over the conventional molecular and inorganic nanosensitizers (i.e., polymeric NPs, plasmonic NPs, metallic NPs, lanthanide NPs, etc.) in terms of versatile sensitization of 1 O 2 generation by various mechanisms and fine-tuning of their optoelectronic properties by multiple parameters in the wide UV–vis and NIR-I (700–900 nm) and NIR-II (1000–1700 nm) regions. ,,,,,,,, …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Colloidal Quantum Dots as an Emerging Vast Platform and Versatile Sensitizer for Singlet Molecular Oxygen Generation

Khan,

Brito

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Singlet molecular oxygen ( 1 O 2 ) has been reported in wide arrays of applications ranging from optoelectronic to photooxygenation reactions and therapy in biomedical proposals. It is also considered a major determinant of photodynamic therapy (PDT) efficacy. Since the direct excitation from the triplet ground state ( 3 O 2 ) of oxygen to the singlet excited state 1 O 2 is spin forbidden; therefore, a rational design and development of heterogeneous sensitizers is remarkably important for the efficient production of 1 O 2 . For this purpose, quantum dots (QDs) have emerged as versatile candidates either by acting individually as sensitizers for 1 O 2 generation or by working in conjunction with other inorganic materials or organic sensitizers by providing them a vast platform. Thus, conjoining the photophysical properties of QDs with other materials, e.g., coupling/combining with other inorganic materials, doping with the transition metal ions or lanthanide ions, and conjugation with a molecular sensitizer provide the opportunity to achieve high-efficiency quantum yields of 1 O 2 which is not possible with either component separately. Hence, the current review has been focused on the recent advances made in the semiconductor QDs, perovskite QDs, and transition metal dichalcogenide QD-sensitized 1 O 2 generation in the context of ongoing and previously published research work (over the past eight years, from 2015 to 2023).

show abstract

Chitosan nanocomposites with CdSe/ZnS quantum dots and porphyrin

Abstract: A CdSe/ZnS QD-TPP nanocomposite and energy transfer from QDs to (i) TPP monomers to oxygen generating singlet oxygen (SO) and (ii) TPP aggregates cannot generate SO in chitosan solution.

Cited by 11 publications

References 57 publications

New Conjugates Based on AIS/ZnS Quantum Dots and Aluminum Phthalocyanine Photosensitizer: Synthesis, Properties and Some Perspectives

New Conjugates Based on AIS/ZnS Quantum Dots and Aluminum Phthalocyanine Photosensitizer: Synthesis, Properties and Some Perspectives

Semiconductor quantum dots for photodynamic therapy: Recent advances

Colloidal Quantum Dots as an Emerging Vast Platform and Versatile Sensitizer for Singlet Molecular Oxygen Generation

Contact Info

Product

Resources

About