Chitosan-N-poly(ethylene oxide) brush polymers for reduced nonspecific protein adsorption

Interaction behaviors between chitosan and hemoglobin

“…It is also used as an excellent adsorbent for sorption of phenols [7], polychlorinated biphenyls [8], proteins [9] and heavy metal ions [10][11][12][13]. These applications mostly depend on the interactions between chitosan and the correlative materials [14][15][16][17].…”

Protein interactions with bottle-brush polymer layers: Effect of side chain and charge density ratio probed by QCM-D and AFM

“…Surfaces coated with polymers containing poly(ethylene oxide), PEO, have long been known as efficient for reducing protein adsorption, and in recent years proved to be one of the most attractive methods for controlling biological fouling of surfaces [14][15][16][17][18]. The molecular mechanism underlying the protein resistant properties of PEO has been suggested to be linked to the strong hydration and flexible nature of PEO that results in low van der Waals attraction and strong steric repulsion.…”

Bottle-brush polymers: Adsorption at surfaces and interactions with surfactants

“…This class of polymer has been less studied than block copolymers, which is particularly true for bottle-brush polyelectrolytes with a high side-chain density. However, rather recent results have shown that adsorption of bottle-brush polymers with hydrophilic non-ionic side chains leads to low non-specific protein adsorption, [1][2][3][4] strongly repulsive steric interactions, [5,6] and favourable lubrication properties, [7,8] with friction coefficients as low as achievable with efficient biochemical lubricants such as mucin [9]. A prerequisite for the successful use of physiosorbed bottlebrush polymer layers in applications is a good understanding of their adsorption properties, and how these are affected by the nature of the surface, the polymer architecture, solution composition, and by interactions with surfactants and other polymers present in solution.…”