Chitosan mouthwash: Toxicity and in vivo validation

Costa, Eduardo M.; Silva, Sara; Costa, M.R.; Pereira, M.R.; Campos, Débora A.; Odila, J.; Madureira, Ana Raquel; Cardelle‐Cobas, Alejandra; Tavaria, Freni K.; Rodrigues, António Sebastião; Pintado, Manuela

doi:10.1016/j.carbpol.2014.04.046

Cited by 31 publications

(16 citation statements)

References 43 publications

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“…Furthermore, the investigated compounds do not reveal carcinogenic potential and cardiac toxicity, but they are predicted to induce phospholipidosis and to have some adverse effects: weight loss, acidosis, gastrointestinal toxicity, respiratory failure. Some of the predicted pharmacological and toxicological profiles of the considered WSDC are in good agreement with a few experimental studies revealing that WSDC have no or low cytotoxicity [28,29], no genotoxicity [28], have fat-and cholesterol-binding capacities producing weight loss [30]. Their side effects increase with the molecular weight and degree of deacetylation [31].…”

Section: Discussionsupporting

confidence: 83%

ADME-Tox profiling of some water soluble chitosan derivatives

2017

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Section: Discussionsupporting

confidence: 83%

ADME-Tox profiling of some water soluble chitosan derivatives

2017

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“…It has been previously demonstrated that the natural polymer chitosan had a low cytotoxicity both in vitro and in vivo . For example, carboxymethyl chitosan‐based NPs (200 nm mean diameter) were not found to be cytotoxic up to100 μg/mL in A549 and HKC epithelial cell lines .…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and intracellular fate of PLGA and chitosan‐coated PLGA nanoparticles in Madin–Darby bovine kidney (MDBK) and human colorectal adenocarcinoma (Colo 205) cells

Trif

Florian

Roșeanu

et al. 2015

J Biomedical Materials Res

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Polymeric nanoparticles (NPs) are known to facilitate intracellular uptake of drugs to improve their efficacy, with minimum bioreactivity. The goal of this study was to assess cellular uptake and trafficking of PLGA NPs and chitosan (Chi)-covered PLGA NPs in Madin-Darby bovine kidney (MDBK) and human colorectal adenocarcinoma (Colo 205) cells. Both PLGA and Chi-PLGA NPs were not cytotoxic to the studied cells at concentrations up to 2500 μg/mL. The positive charge conferred by the chitosan deposition on the PLGA NPs improved NPs uptake by MDBK cells. In this cell line, Chi-PLGA NPs colocalized partially with early endosomes compartment and showed a more consistent perinuclear localization than PLGA NPs. Kinetic uptake of PLGA NPs by Colo 205 was slower than that by MDBK cells, detected only at 24 h, exceeding that of Chi-PLGA NPs. This study offers new insights on NP interaction with target cells supporting the use of NPs as novel nutraceuticals/drug delivery systems in metabolic disorders or cancer therapy. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3599-3611, 2015.

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“…In addition, chitosan caused significant reductions in mature biofilm survival [24], [25]. Chitosan-based mouthwash showed significantly higher antibacterial activity against Streptococcus and Enterococcus species than commercially available essential oils and chlorhexidine mouthwashes [25], [26]. Moreover, CS-NPs have been developed for drug encapsulation.…”

Section: Introductionmentioning

confidence: 99%