Chitosan Microspheres as Potential Vaccine Delivery Systems.

A, Saravana Kumar; Ramaswamy, NM

doi:10.5138/ijdd.2010.0975.0215.03052

Cited by 8 publications

(2 citation statements)

References 43 publications

(39 reference statements)

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“…Micro- and nanoparticles of chitosan and its derivatives are the most preferable form of vaccine adjuvants and delivery vehicles [71,72,73]. Microspheres obtained from chitosan are more effective adjuvants for different antigens compared with commonly used microspheres from polylactic acid (PLA) and poly(lactic-co-glycolic) acid (PLGA), since chitosan microspheres provide a controlled release rate of captured antigens [71]. As a result, the need for repeated administrations, which is the main drawback of some currently available vaccines, is eliminated.…”

Section: Adjuvant Familiesmentioning

confidence: 99%

Vaccine Adjuvants Derived from Marine Organisms

Sanina

2019

Biomolecules

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Vaccine adjuvants help to enhance the immunogenicity of weak antigens. The adjuvant effect of certain substances was noted long ago (the 40s of the last century), and since then a large number of adjuvants belonging to different groups of chemicals have been studied. This review presents research data on the nonspecific action of substances originated from marine organisms, their derivatives and complexes, united by the name ‘adjuvants’. There are covered the mechanisms of their action, safety, as well as the practical use of adjuvants derived from marine hydrobionts in medical immunology and veterinary medicine to create modern vaccines that should be non-toxic and efficient. The present review is intended to briefly describe some important achievements in the use of marine resources to solve this important problem.

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Section: Adjuvant Familiesmentioning

confidence: 99%

Vaccine Adjuvants Derived from Marine Organisms

Sanina

2019

Biomolecules

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“…Chitosan can be used to prepare microspheres of different sizes. The combination of microspheres and drugs can avoid the use of organic solvents and prevent the denaturation of antigenic proteins (15). Chitosan has a unique polycationic property.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the effects of concentrated growth factors in two different forms on osteogenesis in�vitro

Wang

Wan

et al. 2019

Mol Med Report

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Extending the release cycle of growth factors to match the cycle of bone remodeling is difficult. When using concentrated growth factors (CGFs), the release of growth factors is excessively rapid. In the present study, CGF samples were prepared by centrifugation. CGF samples were then lyophilized and grinded into a powder, which was termed freeze-dried CGF. The freeze-dried CGF samples were mixed with chitosan-alginate composite hydrogels, and the mixture was lyophilized. The result was a chitosan-alginate composite CGF membrane, which was called sustained-release CGF. This study investigated whether freeze-dried CGF in a chitosan-alginate composite gel can release CGF steadily to achieve effective osteogenesis. The proliferation and osteogenic expression of MC3T3-E1 cells induced by the supernatants from incubation with freeze-dried CGF and sustained-release CGF were evaluated. The concentrations of the growth factors, transforming growth factor β1 (TGF-β1), insulin-like growth factor-1 (IGF-1), platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF), in these two experimental groups at different times were determined by ELISA kits. The freeze-dried CGF showed better osteogenic performance than the sustained-release CGF in the early stages. At later stages, the sustained-release CGF had significant advantages over freeze-dried CGF in terms of promoting osteogenic mineralization. By characterizing the biologic properties of the CGF in the two different forms in vitro , we obtained a better understanding of their clinical effects.

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