Chitosan methacrylate-based bioadhesive: towards a photoresponsive and extrudable material for bone fracture repair

Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma

“…Similarly, the morphology of the polymeric matrix in the S2C1GO nanocomposite hydrogel was imaged by SEM before and after photocrosslinking ( Figure 8E ). Under blue light irradiation, riboflavin degrades and generates free radicals that destabilize the alkene bonds in the methacryloyl groups of SISMA and ChiMA, thus inducing covalent crosslinking between adjacent strands and causing the microstructure to collapse ( Céspedes-Valenzuela et al, 2021b ). Changes in the porous structure are visually perceptible, as pore diameter varies between 2.1 and 27.2 µm with a mean of 11.7 µm for non-irradiated samples, while for irradiated samples, the material exhibits a collapsed structure with no measurable pores.…”

“…Resuspended SISMA and ChiMA solutions were mixed at a 1:1 volume ratio with the working solution to prepare two formulations: SISMA 1%/ChiMA 1% (S1C1) and SISMA 2%/ChiMA 1% (S2C1). The most promising formulation was laden with the GO-v50-DOX nanoconjugate and ascorbic acid (Sigma-Aldrich, St. Louis, MO, United States), which were pre-dispersed in the working solution at 1 mg/ml and 4 mg/ml (S2C1GO) ( Céspedes-Valenzuela et al, 2021b ; Rueda-Gensini et al, 2021 ).…”

DataSheet1.docx

“…Moreover, DOX's self-fluorescence at 480 nm Similarly, the morphology of the polymeric matrix in the S2C1GO nanocomposite hydrogel was imaged by SEM before and after photocrosslinking (Figure 8E). Under blue light irradiation, riboflavin degrades and generates free radicals that destabilize the alkene bonds in the methacryloyl groups of SISMA and ChiMA, thus inducing covalent crosslinking between adjacent strands and causing the microstructure to collapse (Céspedes-Valenzuela et al, 2021b). Changes in the porous structure are visually perceptible, as pore diameter varies between 2.1 and 27.2 µm with a mean of 11.7 µm for nonirradiated samples, while for irradiated samples, the material exhibits a collapsed structure with no measurable pores.…”