Chitosan membranes in a rat model of full-thickness cutaneous wounds: healing and IL-4 levels

Nordback, P H; Miettinen, Susanna; Kääriäinen, Minna; Haaparanta, Anne-Marie; Kellomäki, Minna; Kuokkanen, Hannu; Seppänen, Riitta

doi:10.12968/jowc.2015.24.6.245

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…Regarding the previous section, CS is a unique cationic biocompatible and biodegradable (see Section 5) polysaccharide that can be modified, as required, according to the needed end-use application. This is particularly true for biomedical and pharmaceutical applications ranging from drug delivery systems [164] to functional biomaterials [165], also considering tissue engineering [166], cell culturing [167], regenerative scaffolds [168], wound healing [169], smart hydrogels [170], active nanoparticles [171], anticoagulants [172], gene therapy [173], etc. (Figure 9).…”

Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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Today, chitosan (CS) is probably considered as a biofunctional polysaccharide with the most notable growth and potential for applications in various fields. The progress in chitin chemistry and the need to replace additives and non-natural polymers with functional natural-based polymers have opened many new opportunities for CS and its derivatives. Thanks to the specific reactive groups of CS and easy chemical modifications, a wide range of physico-chemical and biological properties can be obtained from this ubiquitous polysaccharide that is composed of β-(1,4)-2-acetamido-2-deoxy-d-glucose repeating units. This review is presented to share insights into multiple native/modified CSs and chitooligosaccharides (COS) associated with their functional properties. An overview will be given on bioadhesive applications, antimicrobial activities, adsorption, and chelation in the wine industry, as well as developments in medical fields or biodegradability.

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Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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“…In the present study, immunohistochemistry analysis demonstrated an increased the IL-4 for Ch compared with other experimental groups after 8 weeks, indicating that this treatment had the ability to attenuate the progression of OA. In addition, it was demonstrated that IL-4 is a chondroprotective agent which inhibits IL-1β and TNF-a synthesis (Nordback et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Effects of photobiomodulation associated with chitosan viscosupplementation for osteoarthritis: an in vitro and in vivo study

et al. 2020

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The aim of the present study was to investigate the tissue performance of the association of photobiomodulation (PBM) and chitosan hydrogel (Ch), using in vitro and in vivo studies, in culture of chondrocytes and in an experimental model of osteoarthritis (OA) in the knee of rats. Methods The chitosan hydrogel was characterized by pH, gelation time, and degradation rate. For the in vitro study, chondrocyte cells were seeded in the Ch irradiated or not with PBM to assess cell viability and proliferation after 1, 3, and 5 days. For the in vivo study, sixty Wistar rats with OA were randomly distributed: control group (CG), Ch hydrogel injection (Ch), Ch hydrogel injection associated with PBM (Ch/PBM). Results The characterization results revealed that Ch hydrogels can be controlled precisely by variation of the urea and urease concentrations. The in vitro findings demonstrated that Ch and Ch/PBM are biocompatible and noncytotoxic. The in vivo findings showed that PBM associated with Ch prevented articular degeneration by stimulating anabolic factor (TGF-β) and reducing catabolic factor (TNF-α) and increasing the gene related to components of the cartilage extracellular matrix. Conclusion In conclusion, the PBM associated with Ch can be used as a cartilage repair application.

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“…It has been reported that mesenchymal stem cells promote wound healing in damaged skin [22,25]. It has also been shown that different products based on either collagen I or chitosan promote skin wound healing [26,27]. In addition, some reports have shown that regulation of the inflammatory response could be responsible for the regeneration/scar reparation balance [1].…”

Section: Hadmsc Are Viable In Collagen 1/chs/dexamethasonementioning

confidence: 99%

Development of Hydrogel with Anti-Inflammatory Properties Permissive for the Growth of Human Adipose Mesenchymal Stem Cells

Sánchez-Sánchez

Martínez-Arredondo

Martínez-López

et al. 2016

Journal of Nanomaterials

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Skin wound repair requires the development of different kinds of biomaterials that must be capable of restoring the damaged tissue. Type I collagen and chitosan have been widely used to develop scaffolds for skin engineering because of their cell-related signaling properties such as proliferation, migration, and survival. Collagen is the major component of the skin extracellular matrix (ECM), while chitosan mimics the structure of the native polysaccharides and glycosaminoglycans in the ECM. Chitosan and its derivatives are also widely used as drug delivery vehicles since they are biodegradable and noncytotoxic. Regulation of the inflammatory response is crucial for wound healing and tissue regeneration processes; and, consequently, the development of biomaterials such as hydrogels with anti-inflammatory properties is very important and permissive for the growth of cells. In the last years, it has been shown that mesenchymal stem cells have clinical importance in the treatment of different pathologies, for example, skin injuries. In this paper, we describe the anti-inflammatory activity of collagen type 1/chitosan/dexamethasone hydrogel, which is permissive for the culture of human adipose-derived mesenchymal stem cells (hADMSC). Our results show that hADMSC cultured in the hydrogel are viable, proliferate, and secrete the anti-inflammatory cytokine interleukin-10 (IL-10) but not the inflammatory cytokine Tumor Necrosis Factor-alpha (TNF-α).

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Chitosan membranes in a rat model of full-thickness cutaneous wounds: healing and IL-4 levels

Abstract: According to our results chitosan membrane may promote early wound healing, reduce inflammation and affect the IL-4 pathway, however, the membrane degrades at the wound site after day 7.

Cited by 9 publications

References 26 publications

Modification of Chitosan for the Generation of Functional Derivatives

Modification of Chitosan for the Generation of Functional Derivatives

Effects of photobiomodulation associated with chitosan viscosupplementation for osteoarthritis: an in vitro and in vivo study

Development of Hydrogel with Anti-Inflammatory Properties Permissive for the Growth of Human Adipose Mesenchymal Stem Cells

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