Chitosan Mediated Targeted Drug Delivery System: A Review

Abstract

-Chitosan has prompted the continuous movement for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. The primary hydroxyl and amine groups located on the backbone of chitosan allow for chemical modification to control its physical properties. When the hydrophobic moiety is conjugated to a chitosan molecule, the resulting amphiphile may form self-assembled nanoparticles that can encapsulate a quantity of drugs and deliver them to a specific site of action. Chemical attachment of the drug to the chitosan throughout the functional linker may produce useful prodrugs, exhibiting the appropriate biological activity at the target site. Mucoadhesive and absorption enhancement properties of chitosan increase the in vivo residence time of the dosage form in the gastrointestinal tract and improve the bioavailability of various drugs. The main objective of this review is to provide an insight into various target-specific carriers, based on chitosan and its derivatives. The first part of the review is concerned with the organ-specific delivery system using chitosan and its derivatives. The subsequent section considers the recent developments of drug delivery carriers for cancer therapy with special focus on various targeting strategies. __________________________________________________________________________________________

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

“…Medical applications include wound haemostasis and healing, based on antimicrobial properties as well as drug delivery capabilities (Dai et al, 2011;Patel et al, 2010;Pusateri et al, 2003). Both hydrogels and solid scaffolds can be formed from chitosan (Di Martino et al, 2005).…”

“…Increasing the degree of de-acetylation prolongs its degradation time while enhancing cell adhesion (Mao et al, 2004;Di Martino et al, 2005 In vivo differentiation to NP-like cells. Bertolo et al, 2012;Cheng et al, 2010;Cheng et al, 2013;Dai et al, 2011;Iwasaki et al, 2004;Li et al, 2005b;Mao et al, 2004;Di Martino et al, 2005;Patel et al, 2010;Pusateri et al, 2003;Richardson et al, 2008;Roughley et al, 2006;Shao and Hunter, 2007;Sun et al, 2014;Zhang et al, 2014 Alginate Brown seaweed Delayed drug delivery systems Cells cultured in 3D constructs, tested in vivo in murine model. Bron et al, 2011;Chou et al, 2009;Chou and Nicoll, 2009;Guo et al, 1989;Larsen and Haug, 1971;Leone et al, 2008;…”

Synthesis, Characterization and Optimization of Reaction Parameters for Sodium Salt of Partially Carboxymethylated Okra Gum

“…The derivatives of okra gum are prepared under different experimental conditions. Different properties such as moisture regain, rate of hydration, solubility, viscosity and rheology of the derivatives have been studied 13,14 . The properties depend upon polysaccharide chain length, the nature and degree of chemical modification.…”

Synthesis and antimicrobial evaluation of some new quinazolin-4(3H)-one derivatives

“…The chemistry of heterocyclic compounds has been an interesting field of study for a long time [1][2][3][4][5][6]. The synthesis of novel quinazolin derivatives and investigation of their chemical and antimicrobial behavior has gained more importance in recent decades for biological, medicinal and agricultural reasons [5][6][7][8][9].…”