Chitosan Immunomodulatory Properties: Perspectives on the Impact of Structural Properties and Dosage

Fong, David; Hoemann, Caroline D.

doi:10.4155/fsoa-2017-0064

Cited by 81 publications

(60 citation statements)

References 20 publications

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“…The biomedical activity that drew our attention was its immunomodulatory effects. Based on the structural properties and dosage, chitosan has the potential to induce a plethora of cytokines of pro‐ or anti‐inflammatory nature . Another aspect of chitosan which influences its properties is the degree of deacetylation (DDA), its pattern of deacetylation and the molecular weight …”

Section: Introductionmentioning

confidence: 99%

“…Based on the structural properties and dosage, chitosan has the potential to induce a plethora of cytokines of pro-or anti-inflammatory nature. 3 Another aspect of chitosan which influences its properties is the degree of deacetylation (DDA), its pattern of deacetylation and the molecular weight. 4 Gallic acid (GA), a plant phenolic compound, on the other hand, has demonstrated varied pharmacological properties such as antioxidant, antimicrobial and anti-inflammatory.…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory role of chitosan‐based nanoparticles and oligosaccharides in cyclophosphamide‐treated mice

Mudgal

Kinra

et al. 2019

Scand J Immunol

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Chitosan, the deacetylated form of chitin, a natural polysaccharide, is known for its various biomedical applications. The present study aimed at exploring the immunomodulatory properties of chitosan (CSNP) and gallic acid‐grafted chitosan (cGANP) nanoparticles in mice model of cyclophosphamide (CPA)‐induced immunosuppression. In addition, chitooligosaccharides, the hydrolysed form of chitin and chitosan, were also evaluated for its potential against immunosuppression in mice. CPA (80 mg/kg/ip) induced significant immunosuppression, which was reversed with cGANP treatment as indicated by a significant increase in the thymus and spleen indices compared to the CPA‐treated group. The CSNP and chitooligosaccharides (chitin and chitosan) failed to reverse CPA‐induced changes. ELISA revealed an elevation in the levels of IL‐6 and a reduction in IFN‐γ levels with CPA treatment. All the test compounds reduced the IL‐6 levels, whereas only the nanoparticle formulations (CSNP and cGANP) exhibited a significant augmentation in the IFN‐γ levels. Both the cytokines, IL‐6 and IFN‐γ, are secreted separately by two different types of T helper cells (Th cells), which mediate cellular and humoral immune responses in a coordinated manner. Th‐1 cells release IFN‐γ, facilitating cell‐mediated immunity, whereas IL‐6 is released by Th‐2 cells, expediting humoral immune response. The nanoparticles (CSNP and cGANP) seemed to be better immune enhancers than the chitooligosaccharides owing to their ability to reverse the cytokine changes induced by CPA. Overall, it was evident that the nanoparticles, most likely, boosted the cell‐mediated immunity through the induction of the Th‐1 branch of the immune response.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory role of chitosan‐based nanoparticles and oligosaccharides in cyclophosphamide‐treated mice

Mudgal

Kinra

et al. 2019

Scand J Immunol

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“…The active components of natural products provide a potential alternative to conventional immunotherapy for a variety of immunologic diseases and become subject to scientific investigations for many researcher. In this context, the development of medicinal natural product-based immunostimulatory has gained [6][7][8][9][10] Based on several studies, it is reported that chitosan, one of the natural product active compounds derived from the sea, has potent immunostimulatory properties. 9,10 Over the last three decades, there has been increasing number of publications on chitosan and its derivatives in the pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, the development of medicinal natural product-based immunostimulatory has gained [6][7][8][9][10] Based on several studies, it is reported that chitosan, one of the natural product active compounds derived from the sea, has potent immunostimulatory properties. 9,10 Over the last three decades, there has been increasing number of publications on chitosan and its derivatives in the pharmaceutical industry. The chitosan is known to possess many biological activities such as antibacterial, 11,12 antioxidant, 13 matrix metalloproteinase (MMP) inhibition, 14 antidiabetic, 15 anti-HIV, 16 anti-inflammatory activities, only restricted to those activities, but also chitosan modification will enhance and open various ways to utilize chitosan.…”

Section: Introductionmentioning

confidence: 99%

Immunostimulatory Activity of Chitosan Nanoparticles on Wistar Albino Rats

Sudjarwo¹,

Mahmiah²,

Sudjarwo³

2018

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Background:The active components of natural products provide a potential alternative to conventional immunotherapy for a variety of diseases conditions and become subject to scientific investigations currently worldwide. Objective: The purpose of this research was to investigate the immunostimulatory activity of the chitosan nanoparticle on Wistar albino rats. Materials and Methods: The present investigation was carried out on various groups of healthy adult rats. The assessment of immunomodulatory potential was carried out by neutrophil adhesion test, delayed-type hypersensitivity (DTH) response, haemagglutinating antibody (HA) titre, cyclophosphamide-induced myelosuppression and phagocytic activity were determined in various groups of animals. Results: The administration of chitosan nanoparticle at doses 300 mg/kg BW and 600 mg/kg BW but not at doses 150 mg/kg BW significantly increased in neutrophil adhesion fibers, haemagglutinating antibody titre values and potentiated the inhibited type hypersensitivity reaction induced by sheep red blood cells. Also, it had good response towards phagocytosis in carbon clearance assay and prevented myelosuppression of cyclophosphamide on rats. Conclusion: From these findings, it can be concluded that chitosan nanoparticle responsible for immunostimulatory activity and has therapeutic potential for the prevention of immune depressed conditions.

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“…A novel multilayered coating with chitosan and diclofenac was introduced as potential application for improving longevity of stainless steel hip replacements . Hence, defining the CD68‐related mechanisms under which chitin and chitosan trigger or fail to trigger immunogenic and proinflammatory responses can be beneficial for the translational relevance of chitosan involving various potential applications pertinent to devices, vaccines, drug and gene delivery, and tissue engineering …”

Section: Discussionmentioning

confidence: 99%

In silicoapproaches for enhancing retrieval analysis as a source for discovery of implant reactivity‐related mechanisms and biomarkers

et al. 2019

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The ability to characterize implant debris in conjunction with corresponding immune and tissue‐destructive responses renders retrieval analysis as an important tool for evaluating orthopedic devices. We applied advanced analytics and in silico approaches to illustrate the retrieval‐based potential to elucidate host responses and enable discovery of corresponding biomarkers indicative of in vivo implant performance. Hip retrieval analysis was performed using variables based on immunostaining, polarized microscopy, and fretting‐corrosion and oxidation analyses. Statistical analyses were performed in R. Hierarchical/k‐means clustering and principal component analysis were used for data analysis and visualization. Correlation Engine (CE) and Ingenuity Pathway Analysis (IPA) were employed for in silico corroboration of putative biomarkers. Higher giant cell and histiocyte scores and positivity for CD68 and CD3 indicating infiltration with macrophages and T‐cells, respectively, were detected mainly among older generation hips with higher ultra‐high‐molecular‐weight‐polyethylene loads. Our in silico analysis using pre‐existing data on wear particle‐induced loosening substantiated the role of CD68 in implant‐induced innate responses and identified the CD68‐related molecular signature that can be indicative of development of aseptic loosening and can be further corroborated for diagnostic/prognostic testing in clinical setting. Thus, this study confirmed the great potential of advanced analytics and in silico approaches for enhancing retrieval analysis applications to discovery of new biomarkers for optimizing implant‐related preclinical testing and clinical management. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:263–271, 2020.

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Chitosan Immunomodulatory Properties: Perspectives on the Impact of Structural Properties and Dosage

Cited by 81 publications

References 20 publications

Immunomodulatory role of chitosan‐based nanoparticles and oligosaccharides in cyclophosphamide‐treated mice

Immunomodulatory role of chitosan‐based nanoparticles and oligosaccharides in cyclophosphamide‐treated mice

Immunostimulatory Activity of Chitosan Nanoparticles on Wistar Albino Rats

In silicoapproaches for enhancing retrieval analysis as a source for discovery of implant reactivity‐related mechanisms and biomarkers

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