Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of miRNA-146a to Treat Allergic Rhinitis

Su, Yu Chin; Sun, Bixi; Gao, Xiaoshu; Liu, Shuwen; Hao, Rubin; Han, Bing

doi:10.3390/pharmaceutics12100907

Cited by 22 publications

(18 citation statements)

References 41 publications

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“…CS-based thermosensitive hydrogels were also successfully developed for the local treatment of nasal wounds [ 161 ] and allergic rhinitis [ 162 ].…”

Section: Chitosan-based Mucosal Drug Delivery Systemsmentioning

confidence: 99%

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

et al. 2022

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Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects. Since joining the pharmaceutical field, in the early 1990s, CS attracted great interest, which has constantly increased over the years, due to its several beneficial and favorable features, including large availability, biocompatibility, biodegradability, non-toxicity, simplicity of chemical modifications, mucoadhesion and permeation enhancer power, joined to its capability of forming films, hydrogels and micro- and nanoparticles. Moreover, its cationic character, which renders it unique among biodegradable polymers, is responsible for the ability of CS to strongly interact with different types of molecules and for its intrinsic antimicrobial, anti-inflammatory and hemostatic activities. However, its pH-dependent solubility and susceptibility to ions presence may represent serious drawbacks and require suitable strategies to be overcome. Presently, CS and its derivatives are widely investigated for a great variety of pharmaceutical applications, particularly in drug delivery. Among the alternative routes to overcome the problems related to the classic oral drug administration, the mucosal route is becoming the favorite non-invasive delivery pathway. This review aims to provide an updated overview of the applications of CS and its derivatives in novel formulations intended for different methods of mucosal drug delivery.

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“…CS-based thermosensitive hydrogels were also successfully developed for the local treatment of nasal wounds [ 161 ] and allergic rhinitis [ 162 ].…”

Section: Chitosan-based Mucosal Drug Delivery Systemsmentioning

confidence: 99%

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

et al. 2022

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“…To date, several substances have been used to develop delivery systems for miR-146a and its mimics, including viral vectors such as adenovirus ( 162 ) and nano-carriers consisting of polyethylene glycol-poly (lactic acid) nanoparticles ( 163 ), cerium oxide nanoparticles ( 164 ) and polyethyleneimine nanoparticles ( 105 ). To promote absorption, the nanoparticles are frequently modified with lectins or penetrating peptides ( 165 ) or doped with chitosan ( 166 ). Although viral vectors possess good stability and transfection efficiency, they may induce adverse inflammatory responses.…”

Section: Application Strategiesmentioning

confidence: 99%

Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels (Review)

2022

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In the progression of various diseases, inflammation has a critical role. Chronic persistent inflammation is a pivotal trigger of fibrosis. Several microRNAs (miRNAs) participate in inflammation and fibrosis. In recent years, it has been proved that miRNAs are a critical link in physiological and pathological processes. Among them, the miRNA miR-146a has a pivotal role in the immune system and acquired immunity, making it one of the most studied miRNAs. Due to its essential roles at the molecular and cellular levels, it has broad application prospects in precision medicine. The present comprehensive review focused on the mechanisms of miR-146a and its application strategies in inflammation and fibrosis, discussing its therapeutic potential. The main signaling pathways through which miR-146a regulates inflammation and fibrosis and their relationships were covered. Furthermore, the functions and effects of miR-146a in specific cells, which may join in the process of inflammation and fibrosis, were outlined. Application strategies were also summarized according to recent studies based on these mechanisms. Contents 1. Introduction 2. Location and transcription regulation of miR-146a 3. miR-146a and inflammation 4. miR-146a and fibrosis 5. Application strategies 6. Conclusions and perspectives

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“…20 Furthermore, RNAi-mediated gene therapy has excellent treatment specificity and can be conveniently carried out using various non-viral nanovectors, such as dendrimers, 14,21 dendrimer-incorporated hybrid nanoparticles, 22,23 and nanoscale formulations of solid lipid, 24 chitosan 25 and polylactic acid (PLA). 26 For instance, chitosan nanogels doped with polyethylene glycol-PLA can be used to deliver miRNA-146a for improved anti-inflammatory therapy of allergic rhinitis. 26 The miRNA-146a could effectively inhibit TNF receptor associated factor 6 (TRAF6) involved in the Toll-like receptor 4 (TLR4)/ myeloid differentiation factor 88 (MyD88) signaling pathway, thereby blocking the downstream nuclear transcription factorkappa B activation-induced pro-inflammatory cytokine overexpression.…”

Section: Introductionmentioning

confidence: 99%