Chitosan Hydrogel as a Base for Transdermal Delivery of Berberine and Its Evaluation in Rat Skin.

Tsai, Cheng‐Kun; Hsu, Li‐Che; Fang, Jia‐You; Lin, Hung-Hong

doi:10.1248/bpb.22.397

Cited by 49 publications

(17 citation statements)

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“…15,16) CH is a polycationic polymer and it has been used to prepare some gel formulations 17,18) and to fabricate transdermal devices for the both lipophilic and hydrophilic drugs. 19,20) A polymeric material namely Gantrez ® has been used to prepare topical gel formulations for transdermal applications. 21) G-SP215 is a monoethyl ester of poly(methyl vinyl ether/maleic acid).…”

Section: Resultsmentioning

confidence: 99%

Transdermal Administration of Bromocriptine.

Değim

Acartürk

Erdoğan

et al. 2003

Biological & Pharmaceutical Bulletin

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Bromocriptine (BRC) is a semi-synthetic ergot alkaloid and it has been used for the treatment of diseases caused by hyperprolactinemia and for some neurological disorders as a dopamine agonist in clinics.1) BRC is mainly used for the inhibition of lactation, 2) treatment of menstrual disorders, 3) Parkinson disease, 4) breast tumours, 5) infertility 6) and brain tumours. 7)Bromocriptine is well absorbed through the GI tract but it has low bioavailability because of the hepatic first pass effect, but many patients have complained with GI side effects, headache and dizziness.4) The long acting injectable form of BRC has been developed 2) and it avoids the gastrointestinal side effects but it is expensive and cannot be self-administered.An alternative delivery route such as vaginal application of BRC has been reported. 8,9) Bromocriptine is well absorbed from vagina. Acartürk and Altug have studied the vaginal ring formulation of BRC with polydimethylsiloxane in vitro and in vivo in rabbits. 10,11) It was shown that the controlled release intravaginal ring containing BRC was found to be effective to decrease the plasma prolactin level in rabbits.BRC has also used for the treatment of Parkinson disease and the transdermal administration may be more useful than vaginal administration, being not gender limited. Transdermal delivery of drugs is also very convenient from the application point of view and it offers several advantages over the other routes of drug administration and termination of the drug input is possible in problematic cases. 12,13) Transdermal systems represent one of the most successful non-oral systemic drug delivery system. However, because of limitations of the technology, the physical, chemical nature of the compounds and also lack of the knowledge about penetration mechanisms, transdermal drug delivery is not suited to all drugs and it needs to be justified for the therapies.14)The penetration mechanisms, histopathological hazards of the enhancers and vehicles need to be clarified.The aim of this study was to investigate an alternative delivery route for BRC. Several topical BRC gel formulations were developed using Carbopol (C-934), Daichitosan (CH) and Gantrez-SP215 (G-SP215) and applied to rabbits. Commercially available BRC tablets (Parlodel ® ) were also given to rabbits orally and plasma levels were compared. Two different penetration enhancers, sodium taurocholate (ST) and ethoxydiglycol-Transcutol ® (TR) were also used to improve BRC penetration. Preparation of Gel Formulations For formation of the gel, CH or C-934 was dispersed in water then acetic acid or 0.01 N NaOH was added, respectively. BRC was dissolved in absolute ethanol and then mixed with the gel. TR or ST was added for the preparation of CH-ST or CH-TR gel. G-SP215 solution in ethanol was neutralised by triethanolamine and mixed with BRC solution in ethanol. Bromocriptine (BRC) has been mainly used for the inhibition of lactation, treatment of menstrual disorders, Parkinson disease, breast tumours, infertility and brain tumo...

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Section: Resultsmentioning

confidence: 99%

Transdermal Administration of Bromocriptine.

Değim

Acartürk

Erdoğan

et al. 2003

Biological & Pharmaceutical Bulletin

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“…This polymer was also utilized in developing hydrogel-based matrix diffusion controlled and membrane permeation controlled transdermal systems of diltiazem. The in vivo permeation studies in rat model signified the prospective of this polymer to deliver effective concentration of drug for a prolonged period of time [46]. Several studies were also reported wherein chitosan-based hydrogel transdermal systems have been successfully utilized [47].…”

Section: Hydrogels For Transdermal Delivery Of Drugsmentioning

confidence: 99%

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Ibrahim¹,

Nair²,

Al‐Dhubiab³

et al. 2017

Liposomes

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Polymeric networks that retain and absorb substantial amount of water or biological fluids and resemble as a biological tissue are defined as hydrogels. On the other hand, liposomes, transfersomes and niosomes are lipid carriers, which represent one of the major research and development focus areas of the pharmaceutical industry. They have great potential as lipid vehicles that are able to enhance permeation of drugs across the intact skin and can act as local depot for the drug to sustain and control its delivery. Lipid carrier and hydrogel combinations offer transdermal drug delivery of great potential to enhance systemic effects of both hydrophilic and lipophilic drugs. Also, lipid carriers can target drugs to skin appendages and improve transdermal delivery. Lipid carrier proform systems in the form of gelly liquid crystals can also be used transdermally for better drug absorption enhancement. This review highlights the potential of hydrogels and emulgels with or without lipid nanocarriers for dermal and transdermal application.

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“…A rapid rate of curcumin release was observed by the vertical diffusion cell method. A transdermal delivery system for the treatment of cutaneous leishmaniasis was developed by incorporating berberine into a chitosan hydrogel 52 . The in vitro skin perfusion studies indicated that only trace amounts of berberine permeated through the rat skin due to its low oil-water partition coefficient.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications

Giri¹,

Thakur²,

Alexander³

et al. 2012

Acta Pharmaceutica Sinica B

295

137

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Chitosan, a natural cationic polysaccharide, is prepared industrially by the hydrolysis of the aminoacetyl groups of chitin, a naturally available marine polymer. Chitosan is a non-toxic, biocompatible and biodegradable polymer and has attracted considerable interest in a wide range of biomedical and pharmaceutical applications including drug delivery, cosmetics, and tissue engineering. The primary hydroxyl and amine groups located on the backbone of chitosan are responsible for the reactivity of the polymer and also act as sites for chemical modification. However, chitosan has certain limitations for use in controlled drug delivery and tissue engineering. These limitations can be overcome by chemical modification. Thus, modified chitosan hydrogels have gained importance in current research on drug delivery and tissue engineering systems. This paper reviews the general properties of chitosan, various methods of modification, and applications of modified chitosan hydrogels.

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Chitosan Hydrogel as a Base for Transdermal Delivery of Berberine and Its Evaluation in Rat Skin.

Cited by 49 publications

References 0 publications

Transdermal Administration of Bromocriptine.

Transdermal Administration of Bromocriptine.

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications

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