Chitosan hydrochloride salt stabilized emulsion as vaccine adjuvant

Wang, Danyang; Zou, Yongjuan; Wang, Ning; Wu, Jie

doi:10.1016/j.carbpol.2022.119879

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…Since conventional emulsion adjuvants are stabilized by non-ionic surfactants, their electroneutrality limits the loading efficiency of negatively charged antigens. The chitosan salt facilitated the loading of negatively charged Ovalbumin (adsorption rate of up to 97.99 ± 0.33%) and significantly enhanced humoral immunity by boosting recognition/uptake by APCs (via charged interaction) [259]. Chitosan-based systems have also been widely investigated as vectors for intranasal vaccine delivery.…”

Section: Bioimagingmentioning

confidence: 99%

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

et al. 2023

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Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science.

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Section: Bioimagingmentioning

confidence: 99%