Chitosan/HPMC-based mucoadhesive film co-loaded with fluconazole and ofloxacin for management of polymicrobial keratitis

Sanap, Sachin Nashik; Bisen, Amol Chhatrapati; Kedar, Ashwini; Yadav, Karan Singh; Krishna, Atul; Akhir, Abdul; Chopra, Sidharth; Mugale, Madhav Nilakanth; Bhatta, Rabi Sankar

doi:10.1016/j.ijbiomac.2022.10.058

Cited by 20 publications

(12 citation statements)

References 31 publications

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“…[101][102][103][104] Numerous nano-systems and formulation strategies have been devised to address the complexities of keratitis-related issues, utilizing a variety of antimicrobial agents. [96,[105][106][107][108][109] Nevertheless, only a limited number of studies have directed their attention towards tackling the secondary complication of corneal scarring. In our prior publication, we presented the in vivo pharmacokinetic behaviour of pirfenidone and its promising utility as an antiscarring agent for addressing ulcerative fungal keratitis and related conditions.…”

Section: Ulcerative Microbial Keratitismentioning

confidence: 99%

Pirfenidone: A Promising Drug in Ocular Therapeutics

Bisen,

Agrawal,

Rayiti

et al. 2024

Chemistry & Biodiversity

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Pirfenidone, initially indicated for lung fibrosis, has gone beyond its original purpose, and shown promise in eye care. This detailed review tracks its evolution from lung treatment to aiding eye healing as evidenced by published literature. Pirfenidone's multifaceted attributes extend to mitigating corneal fibrosis, inflammation, and trauma. Through rigorous investigations, its efficacy emerges in diabetic retinopathy, macular degeneration, and postoperative glaucoma interventions. As an unheralded protagonist, pirfenidone reshapes ocular care paradigms, inviting renewed research opportunities.

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Section: Ulcerative Microbial Keratitismentioning

confidence: 99%

Pirfenidone: A Promising Drug in Ocular Therapeutics

Bisen,

Agrawal,

Rayiti

et al. 2024

Chemistry & Biodiversity

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“…Improving bioavailability using mucoadhesive drug delivery systems is a very useful approach applied in various routes of administration: oromucosal [ 30 ], nasal [ 31 ], ocular [ 32 ], and buccal [ 33 ].…”

Section: Ocular Anatomy and Physiologymentioning

confidence: 99%

Biopolymers in Mucoadhesive Eye Drops for Treatment of Dry Eye and Allergic Conditions: Application and Perspectives

Račić

Krajišnik

2023

Pharmaceutics

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Dry eye syndrome and allergic conjunctivitis are the most common inflammatory disorders of the eye surface. Although eye drops are the most usual prescribed dosage form, they are characterized by low ocular availability due to numerous barrier mechanisms of the eye. The use of biopolymers in liquid ophthalmic preparations has numerous advantages, such as increasing the viscosity of the tear film, exhibiting bioadhesive properties, and resisting the drainage system, leading to prolonged retention of the preparation at the site of application, and improvement of the therapeutic effect. Some mucoadhesive polymers are multifunctional excipients, so they act by different mechanisms on increasing the permeability of the cornea. Additionally, many hydrophilic biopolymers can also represent the active substances in artificial tear preparations, due to their lubrication and moisturizing effect. With the modification of conventional ophthalmic preparations, there is a need for development of new methods for their characterization. Numerous methods for the assessment of mucoadhesiveness have been suggested by the literature. This review gives an overview related to the development of mucoadhesive liquid ophthalmic formulations for the treatment of dry eye and allergic conditions.

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“…Multiple reports are published on individual analyte quantication using HPLC and LC-MS/MS methods in varied biological matrices such as plasma, [28][29][30][31] and ocular tissues 32 and in lacrimal uids. [33][34][35] Pauwels and co-workers reported a complex extraction procedure for VCZ only using ammonium acetate buffer systems for chromatographic separation of plasma matrix samples which on longer runs reduces the MS efficiency by leaving salt residues inside the ion source and gradually blocks ion transfer tube of MS. The recently reported simultaneous method by Ping Gao et al for VCZ and venetoclax is good but least sensitive compared to the present method.…”

Section: Introductionmentioning

confidence: 99%