Chitosan/halloysite nanotubes microcomposites: A double header approach for sustained release of ciprofloxacin and its hemostatic effects

Arshad, Muhammad Shahbaz; Qaiser, M.; Shoaib, Muhammad Harris; Ameer, Nabeela; Ramzan, Nasreen; Hanif, Muhammad; Abbas, Ghulam

doi:10.1016/j.ijbiomac.2022.05.138

Cited by 13 publications

(12 citation statements)

References 45 publications

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“…The differential scanning calorimetry (DSC) spectra were developed by using a Shimadzu calorimeter, model DSC-50, with a nitrogen atmosphere of 50 mL/min and a heating rate of 10 °C/min up to 600 °C. The samples were packed in a 20 aluminum cell, and the DSC curve was taken at the same temperature and time as conventional DSC curves. , …”

Section: Methodsmentioning

confidence: 99%

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Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

et al. 2022

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The study aimed to improve the treatment of impetigo with naturally occurring quercetin and its copper–quercetin (Cu–Q) complex by preparing sustained-release (SR) nanoparticles of polycaprolactone (PCL). The solvent evaporation method was used for the copper–quercetin (Cu–Q) complex formation, and their PCL nanoparticles (PCL-NPs, Q-PCL-NPs, and Cu-Q-PCL-NPs) were prepared by the high-pressure homogenization method. Synthesis of nanoparticles was confirmed by their physicochemical and antibacterial properties of quercetin against Gram-positive as well as Gram-negative bacteria. The percentage loading efficiency of quercetin and release in 100 mM of phosphate buffer pH 7.4 and 5.5 at 37 °C was found to be more than 90% after 24 h with the zero-order release pattern. Minimum inhibitory concentration of nanoparticles was found to increase threefold in the case of Cu-Q-PCL-NPs may be due to the synergistic antibacterial behavior. Scanning electron microscopy showed spherical nanoparticles, and surface roughness was confirmed by atomic force microscopy analysis. Fortunately, no sign of irritation on rat skin even at 3%, was seen. In vitro antioxidant assay by 2,2-diphenyl-1-picrylhydrazyl reduction was found to be ≤80 ± 0.02% which confirmed their scavenging activity. Interestingly, for the ex vivo study, the tape-stripping model was applied against Staphylococcus aureus containing rats and showed the formation of the epidermal layer within 4–5 days. Confirmation of antibacterial activity of pure quercetin, from Cu–Q complex, and their SR release from Q-PCL-NPs and Cu-Q-PCL-NPs was considered an effective tool for the treatment of skin diseases and can be used as an alternative of already resistant ciprofloxacin in impetigo.

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Section: Methodsmentioning

confidence: 99%

“…The samples were packed in a 20 aluminum cell, and the DSC curve was taken at the same temperature and time as conventional DSC curves. 17,18 2.4.4. AFM and Zeta Sizer.…”

Section: Synthesis Of Copper−quercetin Complexmentioning

confidence: 99%

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

et al. 2022

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“…5). 136 In a rat tail amputation experiment, the incorporation of only 2% HNTs resulted in a 66.0% increase in the hemostatic capacity compared with CS alone. Additionally, the use of pegylated HNTs led to an enhanced loading and release percentage of ciprofloxacin in the composite microspheres.…”

Section: Hemostatic Composites Based On Cmsmentioning

confidence: 99%

Progress and future prospects of hemostatic materials based on nanostructured clay minerals

Yang,

Wang,

Yang

et al. 2023

Biomater. Sci.

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“…Arshad [75] Ciprofloxacin ↓Clotting time; ↑CIP loading capacity; Sustained CIP release; Drug antibacterial effect CHT/HNTs MC PEG-HNT and CHT (chitosan) was prepared together using suspension emulsification method, then load CIP.…”

Section: E Colimentioning

confidence: 99%

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

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Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina and silica layers, endowing them with a large surface area and versatile surface chemistries that facilitate selective modifications. Moreover, their substantial pore volume and wide range of pore sizes enable efficient entrapment of diverse functional molecules. This comprehensive review highlights the broad biomedical application spectrum of HNTs, shedding light on their potential as innovative and effective therapeutic agents across various diseases. It emphasizes the necessity of optimizing drug delivery techniques, developing targeted delivery systems, rigorously evaluating biocompatibility and safety through preclinical and clinical investigations, exploring combination therapies, and advancing scientific understanding. With further advancements, HNTs hold the promise to revolutionize the pharmaceutical industry, opening new avenues for the development of transformative treatments.

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Chitosan/halloysite nanotubes microcomposites: A double header approach for sustained release of ciprofloxacin and its hemostatic effects

Cited by 13 publications

References 45 publications

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

Progress and future prospects of hemostatic materials based on nanostructured clay minerals

Recent Advances of Halloysite Nanotubes in Biomedical Applications

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