Chitosan grafted into mesoporous silica nanoparticles as benznidazol carrier for Chagas diseases treatment

Nhavene, Egídio Paulo Francisco; Silva, Wellington Marcos da; Trivelato, Roberto Reis; Gastelois, Pedro Lana; Venâncio, Tiago; Nascimento, Regiane; Batista, Ronaldo J. C.; Machado, Carlos Renato; Macedo, W. A. A.; Sousa, Edésia Martins Barros de

doi:10.1016/j.micromeso.2018.06.035

Cited by 45 publications

(17 citation statements)

References 30 publications

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“…The probable action of GlcNAc is linked to the interactions with the membrane surface, such as the lecithin receptor [68], or by electrostatic interactions with the sialic acid on the parasitical membrane [69]. Chitosan is also used as a drug-carrier for Chagas disease [70,71]. The leishmanicidal activity was described for chitosan [72,73].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

et al. 2021

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The global rise of infectious disease outbreaks and the progression of microbial resistance reinforce the importance of researching new biomolecules. Obtained from the hydrolysis of chitosan, chitooligosaccharides (COSs) have demonstrated several biological properties, including antimicrobial, and greater advantage over chitosan due to their higher solubility and lower viscosity. Despite the evidence of the biotechnological potential of COSs, their effects on trypanosomatids are still scarce. The objectives of this study were the enzymatic production, characterization, and in vitro evaluation of the cytotoxic, antibacterial, antifungal, and antiparasitic effects of COSs. NMR and mass spectrometry analyses indicated the presence of a mixture with 81% deacetylated COS and acetylated hexamers. COSs demonstrated no evidence of cytotoxicity upon 2 mg/mL. In addition, COSs showed interesting activity against bacteria and yeasts and a time-dependent parasitic inhibition. Scanning electron microscopy images indicated a parasite aggregation ability of COSs. Thus, the broad biological effect of COSs makes them a promising molecule for the biomedical industry.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

et al. 2021

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“…BNZ nanocrystals produced by a nanoprecipitation process have been shown to improve the BNZ solubility and permeability, potentiating BNZ trypanocidal activity in acute Chagas disease despite the nanocrystal instability ( 21 ). Mesoporous silica nanoparticles combined with chitosan facilitates cellular uptake, which enhances in vitro trypanocidal activity, but with significant cytotoxicity ( 22 ). Complexes of BNZ and cyclodextrin have been reported as a strategy to increase the hydrophilicity of BNZ, which improves the absorption, permeability, and bioavailability of BNZ oral formulations.…”

Section: Introductionmentioning

confidence: 99%

Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection

Li¹,

Yi²,

Scariot³

et al. 2021

JCI Insight

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Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi ( T . cruzi ), an intracellular pathogen that causes significant morbidity and death among millions in the Americas from Canada to Argentina. Current therapy involves oral administration of the nitroimidazole benznidazole (BNZ), which has serious side effects that often necessitate cessation of treatment. To both avoid off-target side effects and reduce the necessary dosage of BNZ, we packaged the drug within poly(ethylene glycol)-block-poly(propylene sulfide) polymersomes (BNZ-PSs). We show that these vesicular nanocarriers enhanced intracellular delivery to phagocytic cells and tested this formulation in a mouse model of T . cruzi infection. BNZ-PS is not only nontoxic but also significantly more potent than free BNZ, effectively reducing parasitemia, intracellular infection, and tissue parasitosis at a 466-fold lower dose of BNZ. We conclude that BNZ-PS was superior to BNZ for treatment of T . cruzi infection in mice and that further modifications of this nanocarrier formulation could lead to a wide range of custom controlled delivery applications for improved treatment of Chagas disease in humans.

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“…In another study, Nhavene et al . ( 137 ) designed multifunctional MSNs based on MCM-41 functionalized with (3-glycidoxypropy) trimethoxysilane (GPTMS) and chitosan succinate (CS) containing benznidazole (BZ) onto modified MSNs surface aiming to evaluate their action against the parasite Trypanosoma cruzi responsible for Chagas disease. The MSNs-like MCM-41 were successfully prepared with well-defined hexagonal arrays of uniform mesopores network, spherical shape and pores size of 3.3 nm.…”

Section: Msns For Infectious Diseases Treatmentmentioning

confidence: 99%

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and vaccines commonly used to these treatments. Taking into account the scarcity of effective formulation to treat infectious diseases, nanotechnology offers a vast possibility of groundbreaking platforms to design new treatment through smart nanostructures for drug delivery purposes. Among the available nanosystems, mesoporous silica nanoparticles (MSNs) stand out due their multifunctionality, biocompatibility and tunable properties make them emerging and actual nanocarriers for specific and controlled drug release. Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.

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Chitosan grafted into mesoporous silica nanoparticles as benznidazol carrier for Chagas diseases treatment

Cited by 45 publications

References 30 publications

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

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