Chitosan-Grafted Copolymers and Chitosan-Ligand Conjugates as Matrices for Pulmonary Drug Delivery

Abstract

Recently, much attention has been given to pulmonary drug delivery by means of nanosized systems to treat both local and systemic diseases. Among the different materials used for the production of nanocarriers, chitosan enjoys high popularity due to its inherent characteristics such as biocompatibility, biodegradability, and mucoadhesion, among others. Through the modification of chitosan chemical structure, either by the addition of new chemical groups or by the functionalization with ligands, it is possible to obtain derivatives with advantageous and specific characteristics for pulmonary administration. In this paper, we discuss the advantages of using chitosan for nanotechnology-based pulmonary delivery of drugs and summarize the most recent and promising modifications performed to the chitosan molecule in order to improve its characteristics.

Magnetic responsive of paclitaxel delivery system based on SPION and palmitoyl chitosan

“…In addition, it has been proved that physical characteristics of the nanoparticles, such as size and stability, depend on the degree of fatty acid substitution [42]. With increase in the degree of substitution, due to stronger hydrophobic interactions, the tendency to aggregate increases and this phenomenon leads to obvious downward trend in particle size [24] which is clearly shown in Fig.5(a).…”

Isolation, Purification, and Nanotechnological Applications of Chitosan

“…In light of developing efficient carrier systems, multifunctional polysaccharide-based nanomaterials combining diagnostic and therapeutic use have recently attracted intensive interests (Meyers et al 2008). Polysaccharides are a class of biological macromolecules that play important roles in a wide variety of biochemical and biomechanical functions (Andrade et al 2011). Among the several classes of polymeric materials including polysaccharides that have become the important tools for the biomaterial scientists, chitosan possesses unique properties that have recently been used in a wide variety of biomedical applications.…”

Nanopreparations for Oral Administration

“…Thiolated chitosan, quaternization of the primary amine with methyl groups (trimethylchitosan), PEG (poly (ethylene glycol)) chitosan, N-succinyl chitosan and carboxymethyl chitosan derivatives have all been synthesized for oral delivery. [78][79][80][81] Some of these have been used in oral nanopreparations with varying effects.…”