Chitosan‐Gated Magnetic‐Responsive Nanocarrier for Dual‐Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy

Wang, Hui; Mu, Qingxin; Revia, Richard A.; Wang, Kui; Zhou, Xuezhe; Pauzauskie, Peter J.; Zhou, Shuiqin; Zhang, Miqin

doi:10.1002/adhm.201601080

Cited by 28 publications

(25 citation statements)

References 58 publications

(32 reference statements)

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“…P(CitAPDMAEMA) was coated to the surface of Au@TiO 2 @DOX NPs, through a physicochemical interactions, such as π-π stacking, hydrophobic and electrostatic interactions. The Fourier transform infrared (FT-IR) spectra (Figure S6) of P(CitAPDMAEMA)@Au@TiO 2 @DOX NPs confirmed the efficient surface modification of P(CitAPDMAEMA) on the Au@TiO 2 @DOX NPs 39. The resultant P(CitAPDMAEMA)@Au@TiO 2 @DOX NPs showed no remarkable changes in morphology (Figure S7A) as compared to Au@TiO 2 NPs.…”

Section: Resultsmentioning

confidence: 82%

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Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zheng

Wang

et al. 2019

Theranostics

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With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO 2 core-shell nanoparticles, which showed that they could selectively target and efficiently eliminate cancer cells via photothermal therapy (PTT), photodynamic therapy (PDT), pH/NIR-induced drug release, and cationic therapy. Methods : In the present study, the multifunctional therapeutic agent [Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX] was prepared to treat cancer with imaging-guided combination method. Firstly, Au@TiO 2 core-shell nanoparticles (NPs) were synthesized. Taking advantage of broad and strong photoabsorption and reactive oxygen species (ROS) generation, Au@TiO 2 core-shell NPs facilitated the single light-induced PTT and PDT. Next, a chemotherapy drug doxorubicin (DOX) was loaded into Au@TiO 2 core-shell NPs. Then, a biocompatible zwitterionic polymer P(CitAPDMAEMA) was grafted to improve the hemocompatibility of NPs and prolong the circulation time. The polymer also served as a capping or switching material for pH-triggered drug release. In addition, the cationic nature of P(CitAPDMAEMA) eased the binding to human cervical cancer (HeLa) cells and effectively inhibited their growth in acidic environments (termed cationic therapy). Moreover, with Mn 2+ ions immanently chelated, Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX NPs were able to provide enhanced contrast under T 1 - or T 2 -weighted magnetic resonance imaging (MRI). Results : The in vitro and in vivo anticancer experiments demonstrated the tumor was effectively inhibited with minimal side effects by the multifunctional NPs. Conclusions : As far as we know, this is the first presentation of four therapeutic methods into one nanomaterial, which will open up a new dimension for the design of combined treatment.

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Section: Resultsmentioning

confidence: 82%

“…As mentioned previously, it is desirable to develop high-performance biocompatible anticancer agents for cancer treatment, it is necessary to cap or switch nanocarriers with porous structures 39. In light of that, the smart pH-sensitive polymer P(CitAPDMAEMA) was synthesized 29, as shown in Figure 2D.…”

Section: Resultsmentioning

confidence: 99%

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zheng

Wang

et al. 2019

Theranostics

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“…As shown by high resolution transmission electron microscopy (HRTEM) images, CDots are evenly wrapped inside silica matrix and possess very similar particle size, with the average particle sizes of 2.46±0.57, 3.12±0.52, and 3.71±0.48 nm for B‐silica/CDots, Y‐silica/CDots, and O‐silica/CDots (Figure d–f), respectively, indicating that the emission wavelength of silica/CDots composites is independent on the size of CDots . And the three CDots have highly crystalline carbon structure with an interplanar distances of about 0.21, 0.204, and 0.20 nm by the 2D lattice fringes of the CDots (Figure d–f, insets), which are attributed to the (100), (102), and (102) lattice planes of graphitic (sp 2 ) carbon, respectively …”

Section: Resultsmentioning

confidence: 88%

One‐Step Synthesis of Silica‐Coated Carbon Dots with Controllable Solid‐State Fluorescence for White Light‐Emitting Diodes

Zhan

Shang

Chen

et al. 2019

Small

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Carbon dots (CDots)‐based solid‐state luminescent materials have important applications in light‐emitting devices owing to their outstanding optical properties. However, it still remains a challenge to develop multiple‐color‐emissive solid‐state CDots, due to the serious self‐quenching of the CDots in the aggregation or solid state. Herein, a one‐step synthesis of multiple‐color‐emissive solid‐state silica‐coated CDots (silica/CDots) composites by controlling CDots loading fraction and composite morphology to realize the adjustment of emitting color is reported. The emission of resultant silica/CDots composites shifts from blue to orange with the photoluminescence quantum yields of 57.9%, 34.3%, and 32.7% for blue, yellow, and orange emitting, respectively. Furthermore, the yellow emitting silica/CDots composites exhibit an excellent fluorescence thermal stability, and further have been applied to fabricate white‐light‐emitting devices with a high color rendering index of above 80.

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“…These systems generate photoinduced heat that can not only directly kill tumor cells but also serve as a stimulus for chemotherapeutic drug release. [266][267][268] With therapeutic nucleic acids introduced into these chemophotothermal nanosystems, the tumoricidal effect can be further enhanced as a result of synergistic trimodal therapy. In a chemo-gene-photothermal nanotherapeutic system, chemotherapeutic drugs and therapeutic nucleic acids are typically carried by nanomaterials possessing photothermic properties.…”

Section: Photothermic Nanomaterial-mediated Delivery Of Gene-chemo Thmentioning

confidence: 99%

Inorganic Nanomaterial‐Mediated Gene Therapy in Combination with Other Antitumor Treatment Modalities

Lin

Revia

Zhang

2020

Adv Funct Materials

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Cancer is a genetic disease originating from the accumulation of gene mutations in a cellular subpopulation. Although many therapeutic approaches have been developed to treat cancer, recent studies have revealed an irrefutable challenge that tumors evolve defenses against some therapies. Gene therapy may prove to be the ultimate panacea for cancer by correcting the fundamental genetic errors in tumors. The engineering of nanoscale inorganic carriers of cancer therapeutics has shown promising results in the efficacious and safe delivery of nucleic acids to treat oncological diseases in small‐animal models. When these nanocarriers are used for co‐delivery of gene therapeutics along with auxiliary treatments, the synergistic combination of therapies often leads to an amplified health benefit. In this review, an overview of the inorganic nanomaterials developed for combinatorial therapies of gene and other treatment modalities is presented. First, the main principles of using nucleic acids as therapeutics, inorganic nanocarriers for medical applications and delivery of gene/drug payloads are introduced. Next, the utility of recently developed inorganic nanomaterials in different combinations of gene therapy with each of chemo, immune, hyperthermal, and radio therapy is examined. Finally, current challenges in the clinical translation of inorganic nanomaterial‐mediated therapies are presented and outlooks for the field are provided.

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Chitosan‐Gated Magnetic‐Responsive Nanocarrier for Dual‐Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy

Cited by 28 publications

References 58 publications

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

One‐Step Synthesis of Silica‐Coated Carbon Dots with Controllable Solid‐State Fluorescence for White Light‐Emitting Diodes

Inorganic Nanomaterial‐Mediated Gene Therapy in Combination with Other Antitumor Treatment Modalities

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Chitosan‐Gated Magnetic‐Responsive Nanocarrier for Dual‐Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy

Cited by 28 publications

References 58 publications

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

One‐Step Synthesis of Silica‐Coated Carbon Dots with Controllable Solid‐State Fluorescence for White Light‐Emitting Diodes

Inorganic Nanomaterial‐Mediated Gene Therapy in Combination with Other Antitumor Treatment Modalities

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Product

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Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy