Chitosan Films Incorporated with Exopolysaccharides from Deep Seawater Alteromonas sp.

Zarandona, Iratxe; Estupiñán, Mónica; Perez, Carla Cristina; Alonso‐Sáez, Laura; Guerrero, Pedro; Caba, Koro de la

doi:10.3390/md18090447

Cited by 9 publications

(8 citation statements)

References 33 publications

(38 reference statements)

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“…Additionally, XRD measurements plotted in Figure 11 showed the two characteristic peaks of chitosan at 9.5° and 20.1°, and three peaks at 13.5°, 21.3° and 30° for pectin, all of them related to the semicrystalline structure of these polysaccharides [ 58 ]. Concerning the CHI2PEC2 scaffold, two broad peaks were observed at 13.5° and 21.8°, revealing an amorphous structure due to the intermolecular hydrogen bonding and electrostatic interactions between chitosan and pectin [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Zarandona

Bengoechea

Álvarez‐Castillo

et al. 2021

Gels

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Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.

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Section: Resultsmentioning

confidence: 99%

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Zarandona

Bengoechea

Álvarez‐Castillo

et al. 2021

Gels

Self Cite

View full text Add to dashboard Cite

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“…In fact, marine bacteria are currently a very promising source for the discovery of EPS with distinctive structures and unique properties, with applicability in several industrial sectors [ 1 , 13 ]. These EPS often exhibit a high diversity in structure and composition, that might include rare sugars, such as fucose or rhamnose [ 13 , 14 ], which are known to confer the biopolymers’ biological activity [ 12 ]. High content in uronic acids and sulfate groups are also found within marine bacteria derived EPS, which further contributes to their unique properties [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Biotechnological Potential of Extracellular Polysaccharides Synthesized by Alteromonas Strains Isolated from French Polynesia Marine Environments

et al. 2021

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Marine environments comprise almost three quarters of Earth’s surface, representing the largest ecosystem of our planet. The vast ecological and metabolic diversity found in marine microorganisms suggest that these marine resources have a huge potential as sources of novel commercially appealing biomolecules, such as exopolysaccharides (EPS). Six Alteromonas strains from different marine environments in French Polynesia atolls were selected for EPS extraction. All the EPS were heteropolysaccharides composed of different monomers, including neutral monosaccharides (glucose, galactose, and mannose, rhamnose and fucose), and uronic acids (glucuronic acid and galacturonic acid), which accounted for up to 45.5 mol% of the EPS compositions. Non-carbohydrate substituents, such as acetyl (0.5–2.1 wt%), pyruvyl (0.2–4.9 wt%), succinyl (1–1.8 wt%), and sulfate (1.98–3.43 wt%); and few peptides (1.72–6.77 wt%) were also detected. Thermal analysis demonstrated that the EPS had a degradation temperature above 260 °C, and high char yields (32–53%). Studies on EPS functional properties revealed that they produce viscous aqueous solutions with a shear thinning behavior and could form strong gels in two distinct ways: by the addition of Fe2+, or in the presence of Mg2+, Cu2+, or Ca2+ under alkaline conditions. Thus, these EPS could be versatile materials for different applications.

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“…Bacterial exopolysaccharides (EPSs) are high-molecular-weight polymers comprising homopolysaccharides or heteropolysaccharides, with important rheological and physicochemical properties . In 2018, Ramamoorthy et al obtained EPSs from Bacillus thuringiensis RSK CAS4 and demonstrated their anti-tumor activity in vitro .…”

Section: Marine Bacteriamentioning

confidence: 99%

Marine Natural Products: A Potential Source of Anti-hepatocellular Carcinoma Drugs

et al. 2021

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Hepatocellular carcinoma (HCC) has high associated morbidity and mortality rates. Although chemical medication represents a primary HCC treatment strategy, low response rates and therapeutic resistance serve to reduce its efficacy. Hence, identifying novel effective drugs is urgently needed, and many researchers have sought to identify new anticancer drugs from marine organisms. The marine population is considered a "blue drug bank" of unique anti-cancer compounds with diverse groups of chemical structures. Here, we discuss marine-derived compounds, including PM060184 and bryostatin-1, with demonstrated anti-cancer activity in vitro or in vivo. Based on the marine source (sponges, algae, coral, bacteria, and fungi), we introduce pharmacological parameters, compound-induced cytotoxicity, effects on apoptosis and metastasis, and potential molecular mechanisms. Cumulatively, this review provides insights into anti-HCC research conducted to date in the field of marine natural products and marine-derived compounds, as well as the potential pharmacological mechanisms of these compounds and their status in drug development.

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Chitosan Films Incorporated with Exopolysaccharides from Deep Seawater Alteromonas sp.

Cited by 9 publications

References 33 publications

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Characterization and Biotechnological Potential of Extracellular Polysaccharides Synthesized by Alteromonas Strains Isolated from French Polynesia Marine Environments

Marine Natural Products: A Potential Source of Anti-hepatocellular Carcinoma Drugs

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