Chitosan films: crosslinking with EDTA modifies physicochemical and mechanical properties

Abstract

The present study was aimed to develop chitosan-EDTA films and evaluate their physico-chemical and mechanical properties. The physical properties suggested lowest swelling, volume and volume index of films prepared by employing equal weight of chitosan (CH) and EDTA (1.5% w/v). The CH:EDTA film (1:l, on weight basis) showed minimum contact angle, work of adhesion and high negative spreading coefficient indicating lipophilic behavior of film. Further, the FTIR and DSC analysis suggested maximum crosslinking density in film prepared with equal proportion of CH and EDTA. The mechanical properties explored using texture analyzer revealed increasing the proportions of EDTA rendered the films more flexible and decreased their hardness. Furthermore, in vitro permeation of 5-FU and mesalamine with different solubilities showed minimum permeation across CH–EDTA (1:1) film, indicating high crosslinking density that decreased void space inside the film. Hence, the CH–EDTA conjugate could be considered to be possess great potential for various pharmaceutical applications such as film based delivery systems, controlled and sustained delivery systems etc.

Super water-absorbing new material from chitosan, EDTA and urea

“…Despite few reports on the formation of conjugate material between chitosan and EDTA, there is no information in the published literature about the nature of the bond formed and the chemistry of this reaction (Bernkop-Schnurch & Krajicek, 1998;ElSharif & Hussain, 2011a;Loretz & Bernkop-Schnuerch, 2006;Singh, Suri, Tiwary, & Rana, 2012b). Hence, it can be surmised that the formation of distinct chemical bonds between chitosan and EDTA has not been reported.…”

“…Chitosan-EDTA conjugate is used in pharmaceutical field as topical application gel (Valenta, Christen, & Bernkop-Schnürch, 1998b). It has also been shown that chitosan-EDTA conjugates, prepared by using EDTA to crosslink, improves the flexibility of chitosan films and decreases the hardness thus facilitating better controlled and sustained delivery system (Singh, Suri, Tiwary, & Rana, 2012a). Chitosan-EDTA derivatives have been developed as promising candidates for the treatment of bacterial and fungal infections (El-Sharif & Hussain, 2011b).…”

Okra Fruit Gum-Chitosan Impregnated Polymer Network Films: Formulation and Substantial Depiction

“…In addition, the Wa values of OC3 film was found to be significantly (p < 0.05) different with respect to those of other films in all the buffers (Table 1). Negative value of spreading coefficient results in the formation of globule rather than film of liquid over a film surface [16]. Thus, the spreading coefficient signified comparatively less water-loving character of all the film surfaces.…”

Physico-chemical, mechanical and electrical performance of bael fruit gum–chitosan IPN films

“…Spreading coefficient of all the film surfaces was found to be negative. Negative value of spreading coefficient is known to result in the formation of globule rather than film of liquid over a film surface (Singh, Suri, Tiwary, & Rana, 2012). Hence, the values of spreading coefficient indicated relatively less hydrophilic character of all the film surfaces.…”