Chitosan Cross-Linking with Acetaldehyde Acetals

Пестов, А. В.; Privar, Yuliya; Slobodyuk, A. B.; Boroda, Andrey V.; Bratskaya, Svetlana

doi:10.3390/biomimetics7010010

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…This band can be assigned to the protonated imine bond (C=N + –H) of an aliphatic Schiff base, formed between chitosan and hydrolyzed acetal group of TGP ( Scheme 3 , structure 3). The possibility of chitosan cross-linking via hydrolyzed acetal group was earlier demonstrated in [ 35 ]. Thus, both types of cross-linkages ( Scheme 3 , structures 2 and 3) can be realized in the reaction between chitosan and TGP.…”

Section: Resultsmentioning

confidence: 99%

Chitosan Cryogels Cross-Linked with 1,1,3-Triglycidyloxypropane: Mechanical Properties and Cytotoxicity for Cancer Cell 3D Cultures

Privar,

Boroda,

Pestov

et al. 2023

Biomimetics

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Here, we have presented a new method of 1,1,3-triglycidyloxypropane (TGP) synthesis and investigated how cross-linker branching affects mechanical properties and cytotoxicity of chitosan scaffolds in comparison with those cross-linked using diglycidyl ethers of 1,4-butandiol (BDDGE) and poly(ethylene glycol) (PEGDGE). We have demonstrated that TGP is an efficient cross-linker for chitosan at a subzero temperature at TGP:chitosan molar ratios from 1:1 to 1:20. Although the elasticity of chitosan scaffolds increased in the following order of the cross-linkers PEGDGE > TGP > BDDGE, TGP provided cryogels with the highest compressive strength. Chitosan-TGP cryogels have shown low cytotoxicity for colorectal cancer HCT 116 cell line and supported the formation of 3D multicellular structures of the spherical shape and size up to 200 µm, while in more brittle chitosan-BDDGE cryogel this cell culture formed epithelia-like sheets. Hence, the selection of the cross-linker type and concentration for chitosan scaffold fabrication can be used to mimic the solid tumor microenvironment of certain human tissue, control matrix-driven changes in the morphology of cancer cell aggregates, and facilitate long-term experiments with 3D tumor cell cultures.

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Section: Resultsmentioning

confidence: 99%

Chitosan Cryogels Cross-Linked with 1,1,3-Triglycidyloxypropane: Mechanical Properties and Cytotoxicity for Cancer Cell 3D Cultures

Privar,

Boroda,

Pestov

et al. 2023

Biomimetics

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“…These studies shed light on the various pesticidal capabilities of these hydrogels and their derivatives against crop viruses and fungi [4,32]. Additionally, these hydrogels function as carriers for fertilizers with promising results for plants growth [39,41,63],…”

Section: Recent Agricultural Applications and Results With Pva/pvp-ba...mentioning

confidence: 99%

Engineering of PVA/PVP Hydrogels for Agricultural Applications

Malka,

Margel

2023

Gels

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Hydrogels have gained significant popularity in agricultural applications in terms of minimizing waste and mitigating the negative environmental impact of agrochemicals. This review specifically examines the utilization of environmentally friendly, shapable hydrogels composed of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) in various casings for crop protection against different pests, fertilizing, and watering. To activate their effectiveness, PVA/PVP hydrogels were loaded with both hydrophilic and hydrophobic environmentally friendly pesticides, namely hydrogen peroxide (HP), the essential oil thymol, and urea as a fertilizer, either separately or in combination. This review covers various physical and chemical approaches used for loading, shaping, and controlling the release profiles of pesticides and fertilizers. Additionally, it explores the evaluation of the chemical composition, structure, classification, rheology, and morphology of the hydrogels as well as their impact on the thermal stability of the encapsulated pesticides and fertilizer, followed by biological tests. These hydrogels significantly contribute to the stabilization and controlled release of essential nutrients and biocides for plants, while maintaining excellent biocidal and fertilizing properties as well as sustainability characteristics. By shedding light on the latest insights into the concepts, applications, and results of these hydrogels, this review demonstrates their immense potential for widespread future use in agriculture.

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“…Amino group can be condensed with the carbonyl group of aldehydes or ketones. The modified chitosan exhibits new properties such as solubility, biological activity 7 , biocompatibility and hydrophilicity 8 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Grafted Chitosan Blending with Polyvinyl alcohol / Nanocomposite and Study Biological Activity

Saeed

Attiya²,

Obead³

2023

Baghdad Sci.J

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The study of biopolymers and their derivative materials had received a considerable degree of attention from researchers in the preparation of novel material. Biopolymers and their derivatives have a wide range of applications as a result of their bio-compatibility, bio-degradability and non-toxicity. In this paper, chitosan reacted with different aldehydes(2,4 –dichloro- benzaldehyde or 2-methyl benzaldehyde), different ketones (4-bromoacetophenone or 3-aminoacetophenone) to produce chitosan schiff base (1-4) . Chitosan schiff base (1-4) reacted with glutaric acid or adipic acid in acidic media in distilled water according to the steps of Fischer and Speier to produce compounds (5-12) respectively. Grafted chitosan (5-12) blended with synthetic polymer PVA to produce compounds (13-20), then these polymers were blended with nano Ag by using a hotplate stirrer for 60 min to produce nanocomposites. The synthesized polymers were identified via spectral analysis techniques, including FTIR , 1H-NMR and scanning electron microscope (SEM). Finally, studied anti-bacterial activities of some of the prepared polymers.

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Chitosan Cross-Linking with Acetaldehyde Acetals

Cited by 7 publications

References 40 publications

Chitosan Cryogels Cross-Linked with 1,1,3-Triglycidyloxypropane: Mechanical Properties and Cytotoxicity for Cancer Cell 3D Cultures

Chitosan Cryogels Cross-Linked with 1,1,3-Triglycidyloxypropane: Mechanical Properties and Cytotoxicity for Cancer Cell 3D Cultures

Engineering of PVA/PVP Hydrogels for Agricultural Applications

Synthesis and Characterization of Grafted Chitosan Blending with Polyvinyl alcohol / Nanocomposite and Study Biological Activity

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