Chitosan composite films: Thermal, structural, mechanical and antifungal properties

Martínez-Camacho, A.P.; Cortez-Rocha, Mario Onofre; Ezquerra‐Brauer, Josafat Marina; Graciano-Verdugo, A.Z.; Rodríguez-Félix, Francisco; Castillo‐Ortega, M. M.; Yépiz-Gómez, María Susana; Plascencia‐Jatomea, Maribel

doi:10.1016/j.carbpol.2010.04.069

Cited by 393 publications

(204 citation statements)

References 51 publications

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“…The endothermic peak in CS thermogram might be related to the glass transition temperature (Tg) of Cs and the exothermic peak at 325°C was probably due to degradation of the polymer (22)(23)(24). Thermograms of nanoparticle formulations were the same and showed only a broad endothermic peak around 140 -170°C.…”

Section: Discussionmentioning

confidence: 99%

Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method

Kouchak

Azarpanah

2015

Jundishapur J Nat Pharm Prod

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Background: Chitosan-based nanoparticle systems have gained wide interest, mainly for their biocompatibility, biodegradability and mucoadhesive properties. Objectives: The aim of this study was to prepare and evaluate diclofenac-loaded chitosan nanoparticles based on the ionotropic gelation method. Materials and Methods: Chitosan (CS) nanoparticles containing diclofenac was prepared using the ionotropic gelation method. Sodium tripolyphosphate (TPP) was used as a polyanion in this process. The effect of some parameters on particle size and drug loading efficiency was evaluated. Results: Transmission electron microscopy (TEM) photographs exhibited typical spherical shape of particles. The mean particle size was within 129 -166 nm and was affected by homogenization, CS/TPP ratio, CS/drug ratio and pH of medium. The maximum drug loading efficiency was estimated as 65.43 ± 7.03% with CS/drug ratio of 10:1. This value tended to decrease by enhancement of drug proportion in the formulations. Differential scanning calorimetry data confirmed the formation of polyelectrolyte complex of TPP and chitosan. Drug release profile in phosphate buffer solutions (pH 6.8, 7.4) showed initial burst effect followed by a slower release pattern. However, release of diclofenac in the acidic medium was negligible. Conclusions: Diclofenac-loaded nanoparticles based on properties of chitosan gelation could delay the release of drugs in the stomach and be further evaluated for the enteric delivery of diclofenac.

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Section: Discussionmentioning

confidence: 99%

Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method

Kouchak

Azarpanah

2015

Jundishapur J Nat Pharm Prod

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“…The mechanism of thermal degradation of pure chitosan has been discussed previously in detail [19,[29][30][31]. As generally accepted, the thermal degradation of chitosan is a free radical mechanism.…”

Section: Effect Of Water Contentmentioning

confidence: 99%

Effect of side substituents on thermal stability of the modified chitosan and its nanocomposites with magnetite

Ziegler-Borowska

Chełminiak

Kaczmarek

et al. 2016

J Therm Anal Calorim

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Three different novel chitosan derivatives for medical or biotechnological applications have been successfully obtained by chemical modification of reactive amino and hydroxyl groups in chitosan chain. The modification has led to incorporation of different amount (one to three) of long-distanced amino and imine groups into each repeating unit. These highly functionalized chitosan derivatives were used as a matrix for magnetite nanoparticles. The thermal stability of all obtained chitosan materials has been determined using thermogravimetric analysis in oxidative and inert atmosphere. Chitosan containing two side substituents behaves differently from the other two, which is caused by the significant water uptake. Magnetite causes decrease in thermal stability of studied chitosan derivatives. The highest stability is observed for the nanocomposite obtained from chitosan with three side groups. The changes in the structure of the magnetite core have been observed above 600°C in nitrogen. Due to the different competitive reactions occurring in the modified chitosan, the proposed mechanism of thermal degradation is very complex.Keywords Modified chitosan Á Side group effect Á Thermogravimetric analysis Á Effect of water residue Á Thermal degradation mechanism

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“…4B), the first stage of decomposition occurs between ambient and 200°C being accounted to around 14% weight loss, corresponding to dehydration of the films. The second stage of decomposition which starts from around 200 to 550°C is attributed to a weight loss due to the decomposition of polymeric network [15,[18][19][20]. For the chitosan-silica film, the second stage starts from 240 to 550°C with the weight loss of 60.0%.…”

Section: Thermal Analysismentioning

confidence: 99%

Physical Characteristics of Chitosan Based Film Modified With Silica and Polyethylene Glycol

2014

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Chitosan composite films: Thermal, structural, mechanical and antifungal properties

Cited by 393 publications

References 51 publications

Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method

Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method

Effect of side substituents on thermal stability of the modified chitosan and its nanocomposites with magnetite

Physical Characteristics of Chitosan Based Film Modified With Silica and Polyethylene Glycol

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