Chitosan coating does not prevent the effect of the transfer of green silver nanoparticles biosynthesized by Streptomyces malachitus into fetuses via the placenta

Elsharawy, Khloud A.; Abou‐Dobara, M. I.; El-Gammal, Hekmat; Hyder, Ayman

doi:10.1016/j.repbio.2020.01.004

Cited by 17 publications

(22 citation statements)

References 61 publications

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“…injected pregnant mice as opposed to negatively charged poly(acrylic acid) (PAA)-coated Fe 2 O 3 NPs [ 69 ]. Additional studies on surface composition were included [ 49 , 61 , 90 ]; one showed a reduction in maternal-fetal transfer after chitosan-coating of Ag NPs [ 49 ]. Other studies reported a time-dependent accumulation of Ag NPs, CeO 2 NPs, and fullerenes as they found that the fetal NP concentration increased over time, reached a peak, and then declined [ 54 , 67 , 87 ].…”

Section: Resultsmentioning

confidence: 99%

“… [ 48 ] Sprague Dawley rats 40 Ag NPs/ citrate 55 b oral/ 0, 0.2, 2, or 20 mg/kg/ GD7–20 d AAS / Higher Ag tissue contents in all treated groups compared to control dams and pups, indicating transplacental Ag NP transfer. [ 49 ] Wistar rats 12 Ag NPs/ chitosan 19.5 ± 6.72 b i.p./ 0 or 100 mg/kg/ GD 6, 8, and 10 d AAS TEM Coated and plain Ag NPs detected in significantly higher levels in maternal tissues, placenta, and fetuses compared to control rats. Chitosan coating decreased the silver content significantly.…”

Section: Resultsmentioning

confidence: 99%

“…, single particle, sector field, and laser ablation ICP-MS), was the most frequently used quantitative technique ( N = 29) among the included studies. In addition, 6 of the included studies used atomic absorption spectrometry (AAS) as elemental analysis tool for detection of metallic NPs in maternal-fetal tissue [ 33 , 44 , 48 , 49 , 59 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

“…As summarized in Table 5 , a multitude of imaging approaches was used to visualize NPs in an in vitro , ex vivo , and in vivo context. Some included studies investigated maternal-fetal NP distribution at the whole-body level by using magnetic resonance imaging [ 71 , 89 ], in vivo/ex vivo fluorescence imaging [ 61 , 62 , 73 , 89 ], or radiolabeling techniques [ 53 , 57 , 70 , 87 ]; whereas other reports focused on the subcellular localization of NPs by exploiting transmission [ 23 , 24 , 27 , 29 – 32 , 41 , 43 , 45 , 47 , 49 , 52 , 54 , 57 , 58 , 60 , 61 , 73 , 75 , 91 , 92 ] or scanning electron microscopy [ 75 , 80 , 93 ]. Fluorescence microscopy is generally the method-of-choice to monitor the cellular and tissue-level distribution of fluorescent NPs [ 143 ].…”

Section: Discussionmentioning

confidence: 99%

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Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies

et al. 2020

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Fetal development is a crucial window of susceptibility in which exposure may lead to detrimental health outcomes at birth and later in life. The placenta serves as a gatekeeper between mother and fetus. Knowledge regarding the barrier capacity of the placenta for nanoparticles is limited, mostly due to technical obstacles and ethical issues. We systematically summarize and discuss the current evidence and define knowledge gaps concerning the maternal-fetal transport and fetoplacental accumulation of (ultra)fine particles and nanoparticles. We included 73 studies on placental translocation of particles, of which 21 in vitro/ex vivo studies, 50 animal studies, and 2 human studies on transplacental particle transfer. This systematic review shows that (i) (ultra)fine particles and engineered nanoparticles can bypass the placenta and reach fetal units as observed for all the applied models irrespective of the species origin (i.e., rodent, rabbit, or human) or the complexity (i.e., in vitro, ex vivo, or in vivo), (ii) particle size, particle material, dose, particle dissolution, gestational stage of the model, and surface composition influence maternal-fetal translocation, and (iii) no simple, standardized method for nanoparticle detection and/or quantification in biological matrices is available to date. Existing evidence, research gaps, and perspectives of maternal-fetal particle transfer are highlighted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies

et al. 2020

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“…Moreover, Li et al [ 54 ] ( ex vivo ), tested NP by targeting of placental tissue for preeclampsia-treatment. Still, Elsharawy et al [ 55 ] ( in vivo ), analyzed the impact of a biosynthesized NP with a polymeric coating on possible targeting to placenta. But aforementioned studies have stopped on the nanotoxicity question, due to the majority using inorganics NP.…”

Section: Nanotherapymentioning

confidence: 99%

The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications

et al. 2020

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During the period of pregnancy, several processes and physiological adaptations occur in the body and metabolism of pregnant woman. These physiological adaptations in pregnant woman end up leading to a suppression in immune system favoring obstetric complications to the mother, fetus and placental tissue. An effective pharmacological therapy for these complications is still a challenge, since some drugs during pregnancy can have deleterious and teratogenic effects. An emerging alternative to pharmacological therapy during pregnancy is drugs encapsulated in nanoparticles (NP), recent area called nano-obstetrics. NP have the advantage of drug targeting and reduction of side effects. Then, maternal, placental or fetal uptake can be expected, depending on the characteristics of NP. Inorganic NP, crossing placental barrier effectively, but have several nanotoxicological effects. While organic NP appear to have a better targeting capacity and have few toxicological effects, but the studies are still scarce. Thus, in this review, were examined questions related to use and impact of physicochemical aspects of inorganic and organic NP during pregnancy.

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Biological impacts of the green synthesized silver nanoparticles on the pregnant albino rats and their fetuses

Abdelaziz

El‐Dakdoky

Ahmed

et al. 2022

Birth Defects Research

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Background With the increasing production and applications of silver nanoparticles (AgNPs), they can be released into the air, water, and soil environments leading to direct exposure to human beings. On this, the current study revealed the physiological, histological, and genotoxic effects of the green biosynthesized AgNPs using two methods; lemon juice or saponin reduction on the maternal and fetal tissues. Methods Twenty‐eight pregnant female rats were divided into four groups (seven/group) and orally administrated the corresponding treatment doses once daily from the first to the 19th gestational day. The first group was administered distilled water as a control. The second group was administrated saponin. The third was administrated AgNps. The fourth was administrated saponin‐loaded silver nanoparticles (Sn‐AgNPs). Results Compared with the control group, the serum of pregnant rats treated with saponin, AgNPs, and Sn‐AgNPs exhibited significant alterations in liver and kidney function parameters. In addition, maternal hepatic and renal tissues showed elevated oxidative stress, with a significant increase in the comet parameters. Histologically, both mothers and fetuses showed changes in the liver and kidney tissues. Conclusions Green synthesized AgNPs have toxic effects on maternal and fetal tissues. Sn‐AgNPs revealed an increase in the transfer, accumulation, and toxicity.

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Chitosan coating does not prevent the effect of the transfer of green silver nanoparticles biosynthesized by Streptomyces malachitus into fetuses via the placenta

Cited by 17 publications

References 61 publications

Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies

Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies

The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications

Biological impacts of the green synthesized silver nanoparticles on the pregnant albino rats and their fetuses

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