Chitosan-coated silver nanoparticles promoted antibacterial, antibiofilm, wound-healing of murine macrophages and antiproliferation of human breast cancer MCF 7 cells

Parthasarathy, Ayyanar; Vijayakumar, Sekar; Malaikozhundan, Balasubramanian; Thangaraj, Merlin P.; Perumal, Ekambaram; Murugan, Thangaswamy; Velusamy, Palaniyandi; Anbu, Periasamy; Vaseeharan, Baskaralingam

doi:10.1016/j.polymertesting.2020.106675

Cited by 52 publications

(26 citation statements)

References 53 publications

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“…The result obtained is comparable to Cu-CsNPs [57]. Also, the zeta potential result agreed with Parthasarathy et al [54] who have reported that the zeta potential of Cs-AgNPs was −21.4 Mv. The characteristics of nanoparticles, particularly the surface morphology, is related to the zeta potential mainly because of optic properties of external polysaccharides and biomolecules [62].…”

Section: Results and Discussion 31 Characterisation Of Cs-agnpssupporting

confidence: 88%

“…Also, Murugan et al [15] noticed that Cs-AgNPs extracted from crab shells were spherical with size ranging from 20 to 50 nm. Recently, Parthasarathy et al [54] highlighted that the cubic shape and the size of Cs-AgNPs were ranged from 8 to 48 nm. Similarly, TEM and SEM analyses of synthesized Cs-AgNPs were spherical in shape and size ranged from 17 to 50 nm [55].…”

Section: Results and Discussion 31 Characterisation Of Cs-agnpsmentioning

confidence: 99%

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Efficacy of chitosan silver nanoparticles from shrimp-shell wastes against major mosquito vectors of public health importance

Alshehri

Aziz

Trivedi

et al. 2020

Green Processing and Synthesis

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Mosquito-borne diseases are causing serious damage to public health worldwide, and control of these deadly mosquito vectors is a major thrust area for epidemiologists and public health workers. Therefore, the present research reports an eco-friendly solution with multipotency of silver nanoparticle fabricated from shrimp shell biowaste in controlling mosquitoes and bacterial pathogens. The biofabricated chitosan silver nanoparticles (Cs-AgNPs) were confirmed by UV-visible spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction and zeta potential analysis. The TEM studies showed that the obtained Cs-AgNPs were mostly spherical in shape. Low doses of chitosan and Cs-AgNPs showed high mosquitocidal properties against both larvae and adult of Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus. The LC50 (lethal concentration 50%) of Cs-AgNPs was 10.240 ppm (fourth instar larvae) and 9.671 ppm (adult) for An. stephensi; 11.349 ppm (fourth instar) and 12.015 ppm (adult) for Ae. aegypti and 12.426 ppm (fourth instar) and 12.965 ppm (adult) for Cx. quinquefasciatus. The concerning part of antibacterial studies showed that Cs-AgNP had significant inhibition on tested bacterial pathogens. Overall, this study shows that chitosan extracted from the shrimp shell wastes can be used as a potential source for controlling major mosquito vectors.

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Section: Results and Discussion 31 Characterisation Of Cs-agnpssupporting

confidence: 88%

Section: Results and Discussion 31 Characterisation Of Cs-agnpsmentioning

confidence: 99%

Efficacy of chitosan silver nanoparticles from shrimp-shell wastes against major mosquito vectors of public health importance

Alshehri

Aziz

Trivedi

et al. 2020

Green Processing and Synthesis

View full text Add to dashboard Cite

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“…The impact of chitosan on the migratory abilities of different cell lines was previously evaluated [35], and the re-sults are encouraging for our system. Formulations containing chitosan have demonstrated improved cell migration in fibroblasts [72], macrophages [73], and keratinocytes [74].…”

Section: Figurementioning

confidence: 99%

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

et al. 2021

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Burns and other skin injuries are growing concerns as well as challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing, are urgently needed for the timely treatment of infection-prone injuries. Treatment of acute skin injuries requires tailoring of formulation to assure both proper skin retention and the appropriate release of incorporated antimicrobials. The challenge remains to formulate antimicrobials with low water solubility, which often requires carriers as the primary vehicle, followed by a secondary skin-friendly vehicle. We focused on widely used chlorhexidine formulated in the chitosan-infused nanocarriers, chitosomes, incorporated into chitosan hydrogel for improved treatment of skin injuries. To prove our hypothesis, lipid nanocarriers and chitosan-comprising nanocarriers (≈250 nm) with membrane-active antimicrobial chlorhexidine were optimized and incorporated into chitosan hydrogel. The biological and antibacterial effects of both vesicles and a vesicles-in-hydrogel system were evaluated. The chitosomes-in-chitosan hydrogel formulation demonstrated promising physical properties and were proven safe. Additionally, the chitosan-based systems, both chitosomes and chitosan hydrogel, showed an improved antimicrobial effect against S. aureus and S. epidermidis compared to the formulations without chitosan. The novel formulation could serve as a foundation for infection prevention and bacterial eradication in acute wounds.

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“…Diabetic wounds are moderate to severe chronic wounds which natural healing is generally disturbed by several disease-associated factors, such as glycemic levels and local hypoxia, peripheral vascular disease and neuropathy, compromised immunodeficiency and opportunistic infections [ 424 ]. The successful use of silver-based nanomaterials in wound therapy relies on their ability to be specifically modified and easily incorporated within dressing materials (which facilitates transportation, protection and control of therapeutic agents), respectively, on the improvement of skin remodeling through antioxidant, anti-inflammatory and proliferative properties [ 425 , 426 ]. Nanosilver has the advantage of better chemical stability and catalytic activity, thus being used as an intrinsic therapeutic agent.…”

Section: Silver Nanoparticles For Wound Carementioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Chitosan-coated silver nanoparticles promoted antibacterial, antibiofilm, wound-healing of murine macrophages and antiproliferation of human breast cancer MCF 7 cells

Cited by 52 publications

References 53 publications

Efficacy of chitosan silver nanoparticles from shrimp-shell wastes against major mosquito vectors of public health importance

Efficacy of chitosan silver nanoparticles from shrimp-shell wastes against major mosquito vectors of public health importance

Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control

An Updated Review on Silver Nanoparticles in Biomedicine

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