Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Ursolic Acid for Breast Cancer Therapy
Pattaree Payomhom,
Nattawadee Panyain,
Chadamas Sakonsinsiri
et al.
Abstract:Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and herbs, has the potential as an anticancer agent against multiple cancer types. Nevertheless, its clinical use was limited by its poor water solubility. To overcome this drawback, several nanocarriers were proposed to increase the bioavailability and efficacy of UA. However, the insights into the cellular targets and mechanisms of UA and UA nanoparticles (NPs) remain limited. In this study, chitosan-coated poly(lactic-co-glycolic acid) (P… Show more
The ursolic acid-loaded poly(lactic-co-glycolic acid) nanoparticles, developed in this study, showed favorable physicochemical properties and have the potential to serve as a drug delivery strategy for enhancing cholangiocarcinoma therapy.
The ursolic acid-loaded poly(lactic-co-glycolic acid) nanoparticles, developed in this study, showed favorable physicochemical properties and have the potential to serve as a drug delivery strategy for enhancing cholangiocarcinoma therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.