Chitosan-coated nickel-ferrite nanoparticles as contrast agents in magnetic resonance imaging

Ahmad, Tanveer; Bae, Hongsub; Iqbal, Yaseen; Rhee, Ilsu; Hong, Sungwook; Chang, Yongmin; Lee, Jaejun; Sohn, Derac

doi:10.1016/j.jmmm.2014.12.077

Cited by 91 publications

(32 citation statements)

References 34 publications

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“…Chitosan-coated MNPs contain a core of magnetic material, usually a mixture of Fe3O4 and γ-Fe2O3 [81], or hybrid MNPs (nickel-ferrite) [82], with the drug loaded on the surface for targeted, controlled release. Dorniani et al [83] designed a new drug nanocarrier by coating chitosan and perindopril erbumine on the surface of MNPs using a simple coating method.…”

Section: Organic Coating Materialsmentioning

confidence: 99%

Magnetic drug delivery systems

Liu

Yang

et al. 2017

Sci. China Mater.

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There has been unprecedented progress in the development of biomedical nanotechnology and nanomaterials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clinical applications. Among these, magnetic drug delivery systems (MDDSs) based on magnetic nanoparticles (MNPs) are attracting increasing attention owing to their favorable biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of superparamagnetic maghemite (γ-Fe2O3) or magnetite (Fe3O4) nanoparticles ranging in size from 10 to 100 nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbubbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically modulating dosing regimens, which are the current challenges for clinical applications.

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Section: Organic Coating Materialsmentioning

confidence: 99%

Magnetic drug delivery systems

Liu

Yang

et al. 2017

Sci. China Mater.

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“…Magnetic nanoparticles have been widely explored for the variety of applications including information devices, data storage, and biomedical applications such as in the drug delivery, 1,2 MRI, [3][4][5] and magnetic hyperthermia. [6][7][8] Magnetic hyperthermia treatment of cancer is a therapeutic concept based on killing cancer by using magnetic nanoparticles as heat generators.…”

Section: Introductionmentioning

confidence: 99%

Silica-coated gadolinium-doped lanthanum strontium manganite nanoparticles for self-controlled hyperthermia applications

2018

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Gadolinium-doped lanthanum strontium manganite (LSM) nanoparticles were synthesized by using a citrate-gel technique. The particles were then annealed at 850 oC to remove defects for a good crystallinity, followed by coating with silica for possible biomedical application to magnetic hyperthermia. The chemical composition was determined to be La0.54Sr0.27Gd0.19MnO3 using an inductively coupled plasma mass spectrometer. The nanoparticles were characterized by X-ray diffraction, transmission electron microscope, and Fourier transform infrared spectrometer to check the perovskite crystalline structure and to observe the particles size and coating status of silica on the surface of the particles. The Curie temperature of the particles was found to be about 280 K. The saturation temperature of the aqueous solution of the particles remained at the hyperthermia target temperature of 42 oC with increasing concentration of particles from 6 to 60 mg/mL in the dispersion. This saturation temperature for a highly concentrated 120-mg/mL-sample increased further, but less than the dangerous temperature of 47 oC for normal tissues. The saturation temperature of the powder sample reached only up to 53 oC. These results showed that the gadolinium-doped LSM nanoparticles can be used for the self-controlled hyperthermia in which the temperature does not exceed the target temperature of hyperthermia even at the tissue site of highly accumulated nanoparticles.

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“…Potential applications of ferrite nanoparticles as MRI contrast agent and hyperthermia led vibrant research activities in biomedical applications[1–9]. In recent time, ferrites containing divalent cations other than Zn such as Co, Ni, Fe, Mn, and Mg are under intense investigations[10] for its possible applications as MRI contrast agent as an attempt to find out newer contrast agents with optimum magnetic and structural properties[11,12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of ZnFe2O4 nanoparticles and its biomedical applications

et al. 2016

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Biomedical applications of ZnFe2O4 nanoparticle are preferable among all kinds of ferrites due to the compatibility of Zn2+ ions for human bodies. We have followed the soft chemical route to synthesize chitosan and PEG coated ZnFe2O4 nanoparticles and also the chitosan-coated-nanoparticles encapsulated with liposome. X-ray diffraction studies by the Mo Kα target, showed the formation of single phase spinel structure. The lattice parameter turned out to be 8.48Å and grain size ~ 4.8 nm (± 0.1 nm). Similar particle size was observed by transmission electron microscope analysis. HRTEM studies showed the distinct lattice fringes thus confirming the good crystallinity of the synthesized nanoparticles. M-H curve at room temperature showed the prepared sample was superparamagnetic in nature, which is also confirmed by the doublets of Mössbauer spectroscopy. Relaxivity values (r2) of Chitosan and PEG coated ZnFe2O4 nanoparticles are 68 and 76 mM−1s−1 respectively. In order to achieve further biocompatibility the chitosan-coated-nanoparticles were encapsulated with liposome. The r2 relaxivity was found as 54mM−1s−1. MR images obtained from the in vitro experiments based on phantoms demonstrated good contrast enhancement. Induction heating of bare and coated particles was investigated to reveal the self heating temperature rising properties of ZnFe2O4 nanoparticles.

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Chitosan-coated nickel-ferrite nanoparticles as contrast agents in magnetic resonance imaging

Cited by 91 publications

References 34 publications

Magnetic drug delivery systems

Magnetic drug delivery systems

Silica-coated gadolinium-doped lanthanum strontium manganite nanoparticles for self-controlled hyperthermia applications

Synthesis and characterization of ZnFe2O4 nanoparticles and its biomedical applications

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