Chitosan-Coated Liposomes: The Strategy to Reduce Intestinal Toxicity and Improve Bioavailability of Oral Vinorelbine

Chen, Guo; Zhu, Xichun; Yuan, Haoyang; Liu, Haoyu; Yin, Tian; He, Haibing; Gou, Jingxin; Tang, Xing

doi:10.1208/s12249-022-02308-7

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…Chitosan interacts with liposomes, enhancing their stability during processing and storage, protecting them from degradation, and preventing unwanted interactions with food components. ( Guo et al, 2022 ). This synergistic approach using chitosan-coated liposomes holds promise for preserving the bioactivity of zein hydrolysate and achieving controlled release within the digestive tract ( Rubaka et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of chitosomes loaded zein on physicochemical, mechanical, microbial, and sensory characteristics of probiotic Kashk during cold storage

Karimi,

Nateghi,

Hosseini

et al. 2024

Food Chemistry: X

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Section: Introductionmentioning

confidence: 99%

Effect of chitosomes loaded zein on physicochemical, mechanical, microbial, and sensory characteristics of probiotic Kashk during cold storage

Karimi,

Nateghi,

Hosseini

et al. 2024

Food Chemistry: X

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“…Multilayer liposomes can be created by layer‐by‐layer electrostatic deposition of positively charged chitosan (CH) around negatively charged liposomes, followed by mixing with negatively charged Sodium alginate (SA) solutions. And they can be used as physical barriers to avoid lipid hydrolysis and oxidation, and improve system stability, allowing active compounds to be released slowly (Ota et al ., 2018; Guo et al ., 2022). However, CH/SA modification on liposome surface has been rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Cinnamon essential oil liposomes modified by sodium alginate‐chitosan: application in chilled pork preservation

Zeng

et al. 2022

Int J of Food Sci Tech

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In this study, cinnamon essential oil liposomes (CEO-Lip), chitosan (CH) modified CEO-Lip (CH-CEO-Lip) and sodium alginate (SA) and CH modified CEO-Lip (SA-CH-CEO-Lip) were prepared based on layer-by-layer electrostatic self-assembly deposition technique and their preservative effects on fresh pork were investigated. The average particle size of SA-CH-CEO-Lip was 178.73 nm with polymer dispersity index (PDI) of 0.380, zeta potential of −23.83 mV. Results showed that the formation of SA-CH-CEO-Lip was efficient (encapsulation efficiency 89.5%). Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) confirmed that SA-CH-CEO-Lip was prepared successfully. The in vitro cumulative release study during 72 h revealed that SA-CH-CEO-Lip (71.42%) showed better sustained release capability than CEO-Lip (81.24%). The pork assessment test showed that SA-CH-CEO-Lip could effectively inhibit the increase in pH, total volatile basic nitrogen (TVB-N) and thiobarbituric acid reactants (TBARS) of pork compared with CEO-Lip group (P < 0.05). The total number of colonies (TBC) showed that the storage life of SA-CH-CEO-Lip group could be extended to 12 days, which was significantly different from that of control group (6 days) (P < 0.05). In addition, SA-CH-CEO-Lip also effectively maintained the good sensory quality of pork. In conclusion, SA-CH-CEO-Lip showed good antiseptic effects on chilled pork preservation.

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Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2

Zhao,

Guo,

Pang

et al. 2023

Nano Res.

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Chitosan-Coated Liposomes: The Strategy to Reduce Intestinal Toxicity and Improve Bioavailability of Oral Vinorelbine

Cited by 6 publications

References 36 publications

Effect of chitosomes loaded zein on physicochemical, mechanical, microbial, and sensory characteristics of probiotic Kashk during cold storage

Effect of chitosomes loaded zein on physicochemical, mechanical, microbial, and sensory characteristics of probiotic Kashk during cold storage

Cinnamon essential oil liposomes modified by sodium alginate‐chitosan: application in chilled pork preservation

Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2

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