Chitosan-coated liposomes encapsulating curcumin: study of lipid–polysaccharide interactions and nanovesicle behavior

Abstract

Despite various spectacular therapeutic properties, curcumin has low bioavailability mainly due to its poor solubility in water.

Design and production of hybrid nanoparticles with polymeric-lipid shell–core structures: conventional and next-generation approaches

“…13,17,18 Although chitosan-coated liposomes are starting to be produced for the delivery of several types of active molecules (e.g., diclofenac sodium, leuprolide, superoxide dismutase, indomethacin, alkaloids, and other types of molecules with therapeutic properties [18][19][20][21][22][23] ), the processes which lead to their production remain at the bench-scale, leading to small product volumes in output. Up to now, the methods usually employed for liposome covering by chitosan are based essentially on dropwise bulk methods 13,18,[24][25][26][27][28][29] such as the layer-bylayer (LbL) method. 30,31 Some efforts have been made towards improvement of these conventional methods using, for example, a supercritical reverse-phase evaporation method, 32 by exploiting complex and expensive apparatus.…”

Effects of Bioactive Marine-Derived Liposomes on Two Human Breast Cancer Cell Lines

“…The membrane fluidity level is tuned according to the membrane's fatty acids (FAs) composition since the presence of saturated FAs increases the packing between phospholipids and thus reduces the membrane fluidity, whereas unsaturated FAs reduces this packing and increase the membrane fluidity [37]. Nanoliposomes derived from salmon lecithin had a relatively high membrane fluidity of 3.15 ± 0.07, which can be decreased by the encapsulation of a bioactive agent or by applying a polymer coating [38]. To facilitate and improve the cell uptake of salmon lecithin, nanoliposomes were generated and characterized ( Figure 1).…”

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

“…Nanoliposomes are natural soft nanoparticles, biocompatible, biodegradable, easy‐to‐fabricate, easy‐to‐decorate, and possess low toxicity . Nanoliposomes can be prepared by sonication, extrusion, or microfluidization method . Nanoliposomes provide more surface area than liposomes and have the potential to significantly improve the controlled release, enhanced bioavailability, increased solubility, and enabled precision targeting of the encapsulated material .…”