Chitosan coated liposomes (CCL) containing triamcinolone acetonide for sustained delivery: A potential topical treatment for posterior segment diseases

Khalil, Madeeha; Hashmi, Muhammad Uzair; Riaz, Ramish; Abbas, Shah Rukh

doi:10.1016/j.ijbiomac.2019.10.256

Cited by 60 publications

(31 citation statements)

References 18 publications

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“…enhancing cornea permeability and long-term fluconazole delivery [74] azithromycin-cholesteryl hemisuccinate ion pair liposomes (ACIP-Lip) improvement of entrapment efficiency and drug loading capacity by the use of ion pair method, continuous and pH-sensitive drug release [72] tetrodotoxin and dexmedetomidine-loaded modified succinyl-Concanavalin A liposomes long period of analgesia, sustainable release of both tetrodotoxin and dexmedetomidine, modified liposomes were persisted on the surface of the cornea for long time duration [75] chitosan coated liposomes Triamcinolone Acetonide delivery sustainable and reliable Triamcinolone Acetonide delivery, high drug encapsulation efficiency along with high positive surface charge [76] polyamidoamine dendrimer (PAMAM G3.0)-coated compound liposomes for berberine hydrochloride enhancement of the bioavailability of berberine hydrochloride with no side effects [77] In the case of local ocular analgesia, a prolonged, minimally toxic drug administration process is clinically desirable, in particular for ophthalmic surgery, whereby frequent drug administration could have numerous negative consequences. Zhan et al showed that a long period of analgesia, 105 min complete, and 608 min partial analgesia and sustainable release of both tetrodotoxin and dexmedetomidine are achievable through the use of modified succinyl-Concanavalin A liposomes.…”

Section: Kinds Of Drug Resultsmentioning

confidence: 99%

“…Moreover, this type of chitosan coated liposome demonstrated nice drug encapsulation efficiency along with high positive surface charge. Note that the cornea surface has a negative charge, and this feature would be helpful in terms of cornea drug delivery applications [76]. One of the main reasons behind the application of the liposomes for ocular drug delivery is the instability and poor bioavailability of that specific drug compound.…”

Section: Kinds Of Drug Resultsmentioning

confidence: 99%

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Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

et al. 2020

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During recent decades, researchers all around the world have focused on the characteristic pros and cons of the different drug delivery systems for cornea tissue change for sense organs. The delivery of various drugs for cornea tissue is one of the most attractive and challenging activities for researchers in biomaterials, pharmacology, and ophthalmology. This method is so important for cornea wound healing because of the controllable release rate and enhancement in drug bioavailability. It should be noted that the delivery of various kinds of drugs into the different parts of the eye, especially the cornea, is so difficult because of the unique anatomy and various barriers in the eye. Nanoparticles are investigated to improve drug delivery systems for corneal disease. Biodegradable nanocarriers for repeated corneal drug delivery is one of the most attractive and challenging methods for corneal drug delivery because they have shown acceptable ability for this purpose. On the other hand, by using these kinds of nanoparticles, a drug could reside in various part of the cornea for longer. In this review, we summarized all approaches for corneal drug delivery with emphasis on the biodegradable nanoparticles, such as liposomes, dendrimers, polymeric nanoparticles, niosomes, microemulsions, nanosuspensions, and hydrogels. Moreover, we discuss the anatomy of the cornea at first and gene therapy at the end.

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Section: Kinds Of Drug Resultsmentioning

confidence: 99%

Section: Kinds Of Drug Resultsmentioning

confidence: 99%

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

et al. 2020

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“…As a result, the IOP lowering efficiency was improved. Khalil et al also prepared CS-coated liposomes for the nanoencapsulation of triamcinolone acetonide for posterior eye delivery [297]. The research team succeeded in preparing uncoated NPs of 18 nm in size while after coating with CS in concentrations of 0.1%, 0.2% and 0.3% w/v, their size increased to Tan et al developed CS-coated liposomes for the ocular delivery of timolol maleate [296].…”

Section: Chitosan Coatingsmentioning

confidence: 99%

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

et al. 2020

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Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.

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“…A new eye drop formulation based on CS-LPs, able to release triamcinolone acetate to the retina as non-invasive and safe drug administration system, has been developed [138]. A good penetration through the corneal mucosal barrier and an accumulation in vitreous body when their efficacy was assessed using a choroidal neovascularization model were observed [139]. Li et al [140] reported the synthesis of CS coated LPs loading cyclosporine A or diclofenac sodium.…”

Section: Cs-lps As Transmucosal Nanocarriersmentioning

confidence: 99%

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

et al. 2021

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In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on chitosan (CS) or chitosan derivatives are broadly investigated as promising nanocarriers due to their biodegradability, good biocompatibility, non-toxicity, low immunogenicity, great versatility and beneficial biological effects. CS, either alone or as composites, are suitable substrates in the fabrication of different types of products like hydrogels, membranes, beads, porous foams, nanoparticles, in-situ gel, microparticles, sponges and nanofibers/scaffolds. Currently, the CS based nanocarriers are intensely studied as controlled and targeted drug release systems for different drugs (anti-inflammatory, antibiotic, anticancer etc.) as well as for proteins/peptides, growth factors, vaccines, small DNA (DNAs) and short interfering RNA (siRNA). This review targets the latest biomedical approaches for CS based nanocarriers such as nanoparticles (NPs) nanofibers (NFs), nanogels (NGs) and chitosan coated liposomes (LPs) and their potential applications for medical and pharmaceutical fields. The advantages and challenges of reviewed CS based nanocarriers for different routes of administration (oral, transmucosal, pulmonary and transdermal) with reference to classical formulations are also emphasized.

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Chitosan coated liposomes (CCL) containing triamcinolone acetonide for sustained delivery: A potential topical treatment for posterior segment diseases

Cited by 60 publications

References 18 publications

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

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