Chitosan-coated liposomes as delivery systems for improving the stability and oral bioavailability of acteoside

Zhou, Fei; Xu, Tao; Zhao, Yajing; Song, Huaxin; Zhang, Liuquan; Wu, Xiaodan; Lu, Baiyi

doi:10.1016/j.foodhyd.2018.04.040

Cited by 125 publications

(62 citation statements)

References 25 publications

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“…Addition of chitosan to the flexible liposomal vesicles resulted in coating of the NPs outer surface by an electrostatic interaction between the positively charged chitosan and the negatively charged NPs surface. This coating process resulted in an enlargement of the vesicles as previously stated [32,46]. Deposition of more chitosan on the NPs surface was achieved at higher polymeric concentration, the effect that results in increasing the zeta potential value and promotion of more drug entrapment in the coated NPs.…”

Section: Discussionsupporting

confidence: 63%

Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity

Ahmed

2020

BMC Pharmacol Toxicol

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Background: Rosuvastatin (RSV) is a poorly water-soluble drug that has an absolute oral bioavailability of only 20%. The aim of this work was to prepare a positively charged chitosan coated flexible lipid-based vesicles (chitosomes) and compare their characteristics to the corresponding negatively charged flexible liposomal nanoparticles (NPs) in order to develop new RSV nanocarrier systems. Methods: Three formulation factors affecting the development of chitosomes nano-formulation were optimized for their effects on the particles size, entrapment efficiency (EE) and zeta potential. The optimized flexible chitosomes and their corresponding liposomal NPs were characterized for morphology, in vitro release, flexibility and intestinal cell viability. The half maximum inhibitory concentrations (IC50) for both formulations were calculated.Results: The drug to lipid molar ratio, edge activator percent and the chitosan concentration were significantly affecting the characteristics of NPs. The optimized chitosomes nano-formulation exhibited larger size, higher EE and greater zeta potential value when compared to the corresponding liposomal NPs. Both formulations showed a spherical shape nanostructure with a marked outer shell for the chitosomes nano-formulation. Chitosomes illustrated an extended drug release profile when compared with the corresponding liposomal NPs and the prepared drug suspension. Flexibility of both vesicles was confirmed with superiority of liposomal NPs over chitosomes. RSV loaded chitosomes nano-formulation exhibited lower IC50 values and higher therapeutic window while liposomal NPs were compatible with the intestinal cells. Conclusions: RSV loaded chitosomes nano-formulation could be considered as a promising nanocarrier system with a marked cytotoxic activity while, RSV loaded liposomal NPs are suitable nanocarrier to improve RSV activity in treatment of cardiovascular disorders.

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Section: Discussionsupporting

confidence: 63%

Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity

Ahmed

2020

BMC Pharmacol Toxicol

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“…17 Chitosan is a biocompatible and biodegradable hydrophilic polymer which, due to its low toxicity, bio-adhesive and permeation-enhancing properties, has received much consideration as a liposome-complexing material for the release and targeting of drugs. 13,17,18 Although chitosan-coated liposomes are starting to be produced for the delivery of several types of active molecules (e.g., diclofenac sodium, leuprolide, superoxide dismutase, indomethacin, alkaloids, and other types of molecules with therapeutic properties [18][19][20][21][22][23] ), the processes which lead to their production remain at the bench-scale, leading to small product volumes in output. Up to now, the methods usually employed for liposome covering by chitosan are based essentially on dropwise bulk methods 13,18,[24][25][26][27][28][29] such as the layer-bylayer (LbL) method.…”

Section: Introductionmentioning

confidence: 99%

Design and production of hybrid nanoparticles with polymeric-lipid shell–core structures: conventional and next-generation approaches

et al. 2018

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“…The amount of the vitamin D3 retained in the suspensions was quantified according to Staffas and Nyman [19] . An aliquot of 0.5 g of each sample was mixed with 10 mL of HPLC grade methanol, vortexed and placed in an ultrasonic bath for 5 min, followed by centrifugation for 5 min at 5000 rpm (Eppendorf AG, Germany) at 10 °C.…”

Section: Vitamin Quantification and Encapsulation Efficiencymentioning

confidence: 99%

“…By forming a stable three-dimensional network, the chitosan-TPP complex is also suitable to coat liposomes by binding to polar heads of lipid bilayers with no alteration in the phospholipids in the vesicles assembling [15,19] . In such hybrid system, the release occurred preferentially in an alkaline pH, what provides protection to acid stress.…”

Section: Introductionmentioning

confidence: 99%

Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol

et al. 2019

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Tripolyphosphate (TPP)-chitosomes were produced aiming at the encapsulation and conservation of vitamin D3. This hybrid system is made of liposomes, vesicles consisting of phospholipid bilayers, surrounded by chitosan wall ionic-crosslinked with TPP. Chitosan concentrations (2 and 4 mg mL-1) were tested and the vitamin stability in aqueous dispersions monitored for 49 days. The results confim that D3 remained stable throughout the analyzed period (49 days), whereas the non-encapsulated vitamin totally degrades after the second week of storage. The particle diameters ranged from 0.1 to 5 μm with good colloidal stability (+22 to +48 mV), and encapsulation efficiency of 97%. Thermal stability was also improved when using the TPP-chitosomes. The protection performed was attributed to the stable interactions conferred by the phospholipids crosslinking with the chitosan amino groups and a formation of a net of hydrogen bonds established amongst the hydroxyl groups of the interacting compounds as revealed by infrared spectroscopy.

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Chitosan-coated liposomes as delivery systems for improving the stability and oral bioavailability of acteoside

Cited by 125 publications

References 25 publications

Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity

Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity

Design and production of hybrid nanoparticles with polymeric-lipid shell–core structures: conventional and next-generation approaches

Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol

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