Chitosan-coated iron oxide/graphene quantum dots as a potential multifunctional nanohybrid for bimodal magnetic resonance/fluorescence imaging and 5-fluorouracil delivery

Hassani, Samad; Gharehaghaji, Nahideh; Divband, Baharak

doi:10.1016/j.mtcomm.2022.103589

Cited by 19 publications

(9 citation statements)

References 50 publications

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“…They have been used in magnetic hybrid nanostructures for cancer treatment because of their biocompatibility and low toxicity. Graphene quantum dots are made of graphene, which is a single layer of carbon atoms arranged in a hexagonal lattice [ 112 ]. They have been shown to have fluorescence properties and have been incorporated into magnetic hybrid nanostructures for cancer treatment because of their high stability and low toxicity.…”

Section: Magnetic Nanomaterials and Their Magnetic Hybrids Nanostruct...mentioning

confidence: 99%

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

et al. 2023

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The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools for cancer diagnosis and treatment in the future. Due to their tunable morphologies and superior properties, multifunctional magnetic nanomaterials and their hybrid nanostructures can be designed as specific carriers of drugs, imaging agents, and magnetic theranostics. Multifunctional magnetic nanostructures are promising theranostic agents due to their ability to diagnose and combine therapies. This review provides a comprehensive overview of the development of advanced multifunctional magnetic nanostructures combining magnetic and optical properties, providing photoresponsive magnetic platforms for promising medical applications. Moreover, this review discusses various innovative developments using multifunctional magnetic nanostructures, including drug delivery, cancer treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal agents, magnetic resonance imaging, and tissue engineering. Additionally, artificial intelligence (AI) can be used to optimize material properties in cancer diagnosis and treatment, based on predicted interactions with drugs, cell membranes, vasculature, biological fluid, and the immune system to enhance the effectiveness of therapeutic agents. Furthermore, this review provides an overview of AI approaches used to assess the practical utility of multifunctional magnetic nanostructures for cancer diagnosis and treatment. Finally, the review presents the current knowledge and perspectives on hybrid magnetic systems as cancer treatment tools with AI models.

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Section: Magnetic Nanomaterials and Their Magnetic Hybrids Nanostruct...mentioning

confidence: 99%

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

et al. 2023

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“…Similar to Karthika et al., [ 85 ] the dual ability of magnetite nanoparticles to serve as targeted delivery vehicles for chemotherapeutics and as contrast enhancement agents for magnetic resonance and fluorescence imaging (MRI/FI) inspired the group of Hassani et al., who fabricated a CS‐coated Fe 3 O 4 ‐GQDs (MGC) nanohybrid loaded with the chemotherapeutic drug 5‐FU (MGC‐FU). [ 94 ] The superparamagnetic characteristics of the nanohybrid facilitated its magnetic targeted delivery ability, as shown by the quick separation of MGC from its solvent by applying external magnetic field. Moreover, the emission of photoluminescence at the blue visible light region (493 nm) allows the nanohybrid to be used for fluorescence imaging.…”

Section: Ddss Based On Cs and Graphene Derivativesmentioning

confidence: 99%

Capitalization of Graphene/Chitosan Nanocomposites as Intriguing Vehicles for Targeted Anti‐Cancer Drug Delivery

Kourti

Theodorakis

Σκούρας

et al. 2023

Advanced Therapeutics

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The effective combination of various polysaccharides with graphene derivatives towards the formation of nanocomposites has gained enormous interest for a number of emerging biological and biomedical applications. The intriguing properties of the individual materials are further improved upon the realization of (nano)composites, thus providing new insights and property enhancement in terms of durability, flexibility, biocompatibility, low‐toxicity, and antibacterial/antimicrobial behavior. Therefore, novel (nano)composite agents have been prepared and investigated to serve as ideal carriers or scaffold materials in regenerative medicine, biosensing, disease diagnosis and treatment, drug delivery, as well as stem cell and tissue engineering applications. This topical review summarizes the most recent studies published during the last quinquennium (2018 – 2022), on the development of anticancer drug delivery systems (DDSs) based on graphene/chitosan nanocomposites. The followed synthetic routes and the integrated properties of the composite materials are analyzed, discussing the impact of their utilization in the field of drug delivery for the treatment of various cancer types. The prospects and future research trends in the field are also discussed.This article is protected by copyright. All rights reserved

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“…However, they must meet the requirements of biocompatibility and non-cytotoxicity to be considered for such a purpose. The literature reports demonstrate different approaches to connecting quantum dots with chitosan through, e.g., CS covalent attachment to graphene quantum dots [ 80 ], CS coating of graphene QD combined with magnetite [ 81 ], or graphene oxide QD functionalized with CS nanoparticles and polyethylene glycol [ 82 ]. In order to prepare the material according to Green Chemistry, carbon chitosan-based quantum dots were prepared using microwave radiation and functionalized with some amino acids (e.g., lysine, cysteine).…”

Section: Chitosanmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

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Chitosan-coated iron oxide/graphene quantum dots as a potential multifunctional nanohybrid for bimodal magnetic resonance/fluorescence imaging and 5-fluorouracil delivery

Cited by 19 publications

References 50 publications

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

Capitalization of Graphene/Chitosan Nanocomposites as Intriguing Vehicles for Targeted Anti‐Cancer Drug Delivery

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

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