Abstract:Corneal disease is the 2nd biggest reason of blindness after cataract. Based on WHO data, it was predicted that 10 million people in the world would suffer from cornea-related sight deficiency. One of the solutions is by using wound dressing to cover the cornea so that it could heal effectively. Several studies were conducted to observe the use of collagen, hyaluronic acid, and PEO for wound dressing. To increase the properties of the membrane, chitosan coating was introduced. In this study, we observe the eff… Show more
“…The membrane's cell viability was non-toxic, and the coating showed antibacterial properties, particularly against Pseudomonas aeruginosa. In summary, the incorporation of a chitosan coating has been found to enhance the properties of the electrospun membrane utilized for wound dressing in cases of corneal ulcers (Putra et al, 2020).…”
Section: Management and Healing Of Ulcersmentioning
Hydrogels have proven to be of great value because of their useful properties and functions. Temperature and pH-sensitive chitosan-collagen-based hydrogels have drawn research interest in the area of wound care. Their unique mechanism allows them to release antimicrobial agents in response to changes in the environment and aids in efficient healing of wounds. The current review aims to describe various composite hydrogels of chitosan and collagen, their temperature and pH sensitivity, the antimicrobial effect of chitosan-collagen hydrogels and their applications in wound healing. Sources and properties of chitosan and collagen have also been stated in order to highlight their importance in these hydrogels. The main focus revolves around the potential of chitosan-collagen hydrogels as antimicrobial biomaterials for healing wounds in an efficient manner.
“…The membrane's cell viability was non-toxic, and the coating showed antibacterial properties, particularly against Pseudomonas aeruginosa. In summary, the incorporation of a chitosan coating has been found to enhance the properties of the electrospun membrane utilized for wound dressing in cases of corneal ulcers (Putra et al, 2020).…”
Section: Management and Healing Of Ulcersmentioning
Hydrogels have proven to be of great value because of their useful properties and functions. Temperature and pH-sensitive chitosan-collagen-based hydrogels have drawn research interest in the area of wound care. Their unique mechanism allows them to release antimicrobial agents in response to changes in the environment and aids in efficient healing of wounds. The current review aims to describe various composite hydrogels of chitosan and collagen, their temperature and pH sensitivity, the antimicrobial effect of chitosan-collagen hydrogels and their applications in wound healing. Sources and properties of chitosan and collagen have also been stated in order to highlight their importance in these hydrogels. The main focus revolves around the potential of chitosan-collagen hydrogels as antimicrobial biomaterials for healing wounds in an efficient manner.
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