Chitosan capsules with hydrogel core for encapsulation and controlled-release of small molecule materials

Song, Weizheng; Zhao, Guangyu; Zheng, Hang; He, Guangyao; Li, Jin; Zhang, Jinchang; Chen, Yanjun; Wang, Yifeng

doi:10.1016/j.matlet.2020.128348

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…The storage-leakage phenomena resulted from the permeating and diffusion effects of the substances with low molecular weight, which were reported in other researches. 41,42 Figure 6b showed the cumulative release curves of sodium salicylate in a 40 C water. Compared with the multilayer capsules without α-CD, the α-CD@gelatin/CS-SDBS multilayer capsules released more sodium salicylate during the same release time.…”

Section: Controlled Release Of α-Cd@gelatin/cs-sdbs Multilayer Capsulesmentioning

confidence: 99%

Fabrication, encapsulation and controlled release of multilayer capsule based on thermosensitivity and host‐guest interaction

Wang,

Liu,

et al. 2024

J of Applied Polymer Sci

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As an efficient means of material carrying, multilayer capsules are widely used in medicine, agriculture, food safety and other fields. Here, we report a kind of temperature‐triggered multilayer capsule with chitosan‐sodium dodecyl benzene sulfonate (CS‐SDBS) as the shell and gelatin bead containing α‐cyclodextrin (α‐CD@gelatin) as the core. The α‐CD@gelatin/CS‐SDBS multilayer capsules can simultaneously encapsulate various substances, such as drugs, fluorescent materials, and nanoparticles. The encapsulated substances do not interfere with each other because they are located in different layers. Both the temperature‐sensitive property of gelatin and the host‐guest interaction between α‐CD and SDBS are utilized to achieve temperature‐controlled release of substances in the multilayer capsules. The release rate can be adjusted by the α‐CD amount in the gelatin beads. The controlled drug release and chemical detection of the multilayer capsules are studied with sodium salicylate, iodine, and purple cabbage pigment as the carriers. The results show that the α‐CD@gelatin/CS‐SDBS multilayer capsules have excellent capabilities of encapsulation and controlled release, which are beneficial for their application in the fields of substance encapsulation, drug‐controlled release, and chemical detection.

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Section: Controlled Release Of α-Cd@gelatin/cs-sdbs Multilayer Capsulesmentioning

confidence: 99%

Fabrication, encapsulation and controlled release of multilayer capsule based on thermosensitivity and host‐guest interaction

Wang,

Liu,

et al. 2024

J of Applied Polymer Sci

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“…Three kinds of liquid, deionized water, 0.1 mol•L −1 HCl and 0.0001 mol•L −1 NaOH, were used, the pH of which were 7.0, 1.0 and 10.0, respectively. The concentration of the liquid containing the Reactive Red X-3B (c) was calculated according to Equation (3).…”

Section: Characterizationsmentioning

confidence: 99%

“…With the demand for health and safety, biomass materials, such as gelatin, xanthan gum, alginate, chitosan, cellulose and its derivatives, which have a high gelling capacity, biocompatibility and low toxicity and are better choices as barrier materials, are used for oil encapsulation [2]. But encapsulation and storage of the water-based materials are still a challenge due to their good water-solubility and water-swelling properties even after crosslinking [3]. The aqueous core mm-caps can only be stored in liquid media like tapioca balls, or they will collapse in the air because of water evaporation from the hydrophilic semipermeable capsule membrane [4].…”

Section: Introductionmentioning

confidence: 99%

Developing Water Barrier Coatings of Millimeter-Scale Hydrogel Capsules via Interfacial Initiated Ethyl Cyanoacrylate by In-Situ Polymerization

Gong,

Zhai,

et al. 2023

Coatings

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The millimeter-scale capsules for oil encapsulation have been used successfully in food, cosmetic and pharmaceutical engineering. However, aqueous core capsules still have poor barrier properties and a short storage life. In this work, a rapid and mild coating method was applied on millimeter-scale calcium alginate aqueous core capsules (mm-CaSA-Caps). A layer of poly(ethyl-cyanoacrylate) (PECA) was coated on the surface of the mm-CaSA-Caps using interfacial polymerization. The PECA-coated mm-CaSA-Caps (PECA@CaSA-Caps) prepared in the trichloromethane maintained a spherical shape in wet and dry conditions. Compared with the mm-CaSA-Caps, the weight loss ratio of water in the PECA@CaSA-Caps decreased by 38.59%. The release rates of dye in PECA@CaSA-Caps greatly reduced in neutral (pH 7.0), alkaline (pH 10.0) and acidic (pH 1.0) conditions. This work provides a new way to improve the barrier properties and storage life of hydrogel capsules.

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“…[12][13][14][15]22 The physical properties of the obtained microparticles are strongly dependent on the nature of the materials and also on the parameters during the manufacture of the microparticles. [3][4][5][6][27][28][29][30][31][32][33][34] A complicated array of factors including type of polymer, polymer molecular weight, polymer concentration, drug loading, type of solvent, the nature of any excipients added to the microparticle formulation (e.g. for stabilization of the therapeutics) and the microparticle size can have a strong impact on the delivery rates.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of various formulation effects of the second emulsion on the shape and release profile of propranolol HCl from ethyl cellulose microparticle blends

Muhaimin

Chaerunisaa

Bodmeier

2022

Polymer International

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The objective of this study was to investigate and characterize incorporated propranolol HCl (Pro) within ethyl cellulose microparticle blends using the solvent evaporation method. The microparticle blends were prepared with a water‐in‐oil‐in‐water (W/O/W) solvent evaporation method and contained the same drug Propranolol HCl (Pro). The first Pro emulsion (W/O) and second Pro emulsion (W/O) were dispersed in an external aqueous phase, with a dispersion time interval (DTI) of 0 and 60 min. The morphology of the microparticle blends was characterized by SEM. The mean particle size, chord length distribution and chord count of the emulsion droplets/hardened microparticles were monitored by focused beam reflectance measurement (FBRM). The encapsulation efficiency and in vitro drug release in phosphate buffer (pH 7.4) were also investigated. The resulting microparticles were spherical, of two populations. The mean particle size of the microparticle blends ranged from 104.26 μm to 127.64 μm. The encapsulation efficiency was about 76.53% to 78.81% for propranolol HCl in the microparticle blends. FBRM studies showed that the size of the microparticle blends prepared by the W/O/W (Pro) method with DTI 60 min and stirring time 4 h was larger than that of the microparticle blends with DTI 0 min. In vitro drug release studies after 28 days showed that the propranolol HCl release from microparticle blends with DTI 60 min (54.05%) was slower than from microparticle blends with DTI 0 min (73.28%). Based on these data, there is an interaction of the second primary emulsion with hard particles from the first primary emulsion, whereby the second primary emulsion blocked and coated pores on the surface of hard particles from the first primary emulsion. These blocking and coating effects of the microparticles depended on the method and the DTI. In conclusion, novel microparticle blends containing drugs of the same solubility offer high potential for controlled release drug delivery systems. © 2022 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.

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Chitosan capsules with hydrogel core for encapsulation and controlled-release of small molecule materials

Cited by 10 publications

References 11 publications

Fabrication, encapsulation and controlled release of multilayer capsule based on thermosensitivity and host‐guest interaction

Fabrication, encapsulation and controlled release of multilayer capsule based on thermosensitivity and host‐guest interaction

Developing Water Barrier Coatings of Millimeter-Scale Hydrogel Capsules via Interfacial Initiated Ethyl Cyanoacrylate by In-Situ Polymerization

Preparation and evaluation of various formulation effects of the second emulsion on the shape and release profile of propranolol HCl from ethyl cellulose microparticle blends

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