Chitosan based thermosensitive injectable hydrogels for controlled delivery of loxoprofen: development, characterization and in-vivo evaluation

Ahmad, Umair; Sohail, Muhammad; Ahmad, Mahmood; Minhas, Muhammad Usman; Khan, Shahzeb; Hussain, Zahid; Kousar, Mubeen; Mohsin, Sabeeh; Abbasi, Mudassir; Shah, Syed Ahmed; Rashid, Haroon

doi:10.1016/j.ijbiomac.2019.02.031

Cited by 67 publications

(30 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For carrying out this study, discs of dried hydrogel were weighed and kept in boiling water at 100 °C for approximately 4 h. The discs were removed from the water bath after 4 h and dried at room temperature for 24 h. Subsequently, they were placed in the incubator at 37 °C. 58 For calculating the sol and gel fraction of the hydrogel, the following formula was employed where W a is the dry weight of the hydrogel, whereas W b represents the weight of the hydrogel after extraction for a definite time, that is, 4 h.…”

Section: Methodsmentioning

confidence: 99%

Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier

2020

View full text Add to dashboard Cite

A thermosensitive, physically cross-linked injectable hydrogel was formulated for the effective and sustained delivery of disulfiram (DSF) to the cancer cells as there is no hydrogel formulation available until now for the delivery of DSF. As we know, hydrogels have an advantage over other drug delivery systems because of their unique properties, so we proposed to formulate an injectable hydrogel system for the sustained delivery of an anticancer drug (DSF) to cancer cells. To investigate the surface morphology, a scanning electron microscope study was carried out, and for thermal stability of hydrogels, TGA (thermogravimetric analysis) and DSC (differential scanning calorimetry) were performed. The rheological behavior of hydrogels was evaluated with the increasing temperature and time. These developed hydrogels possessing excellent biocompatibility could be injected at room temperature following rapid gel formation at body temperature. The swelling index and in vitro drug release studies were performed at different pH (6.8 and 7.4) and temperatures (25 and 37 °C). The cell viability of the blank hydrogel, free DSF solution, and Ch/DSF (chitosan/DSF)-loaded hydrogel was studied by MTT assay on SMMC-7721 cells for 24 and 48 h, which exhibited higher cytotoxicity in a dose-dependent manner in contrast to the free DSF solution. Moreover, the cellular uptake of DSF-loaded hydrogels was observed stronger as compared with free DSF. Hence, chitosan-based hydrogels loaded with DSF possessing exceptional properties can be used as a novel injectable anticancer drug for the sustained delivery of DSF for long-term cancer therapy.

show abstract

Section: Methodsmentioning

confidence: 99%

Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier

2020

View full text Add to dashboard Cite

show abstract

“…used a favorable permutation of Poly‐caprolactone and gelatin to fabricate a nanofibrous scaffold constituting particles of silicate bioceramic for healing of diabetic wounds [97] . The developed nano‐particles were uniformly dispersed throughout the Poly‐caprolactone /gelatin based nanofibers through co‐electrospinning techniques, which introduced constant release action in the fabricated scaffold [36,222] . Ramli et al.…”

Section: Biopolymer Centered Materials For Different Biomedical Applimentioning

confidence: 99%

“…Biopolymers of polypeptide and polysaccharide are well‐known and widely studied for the formation of hydrogel [33,34] . These materials exhibit all the physiochemical properties that assure the development of hydrogels for biomedical applications [35,36] . The polysaccharides contain hydrophilic groups, which helps them to augment the cell‐cell adhesion through non‐covalent bonding with cells and facilitate the polysaccharides‐based metal nanoparticles for biomedical applications [37] .…”

Section: Introductionmentioning

confidence: 99%

“…[33,34] These materials exhibit all the physiochemical properties that assure the development of hydrogels for biomedical applications. [35,36] The polysaccharides contain hydrophilic groups, which helps them to augment the cell-cell adhesion through non-covalent bonding with cells and facilitate the polysaccharides-based metal nanoparticles for biomedical applications. [37] Additionally, polysaccharides could also be used to form efficient drug delivery systems via bring together different drug molecules on to the metal nanoparticles surface.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multifunctional Biopolymers‐Based Composite Materials for Biomedical Applications: A Systematic Review

2021

View full text Add to dashboard Cite

Biopolymers are considered as a favorable group of substances with a broad array of applications, of which biomedical field stands out. The interesting features of biopolymers such as low‐cost, non‐cytotoxicity, hydrophilicity, biodegradation and biocompatibility make them promising and excellent feedstock to be used in implantable devices. The bounteous reactive functional groups in the backbone structure of polysaccharides and its derivatives could be utilized to develop hydrogels, nano‐composite and 3D scaffolds with appealing structures and desired features, leading to promising research attention towards biomedical fields. The present review describes the foremost properties as well as potential of different biopolymers, and their composites for application in implantable biomedical systems. This work may introduce readers about the comprehension of state‐of‐the‐art advances, real present challenges along with the future anticipation of eco‐friendly and biomimetic techniques for the modification of biopolymeric materials to improve their biomedical applications.

show abstract

“…The hydrogel formulation was stable in the rat after i.v . administration and in vivo experiments showed loxoprofen release for up to 144 hrs 180Figure 8Macroscopic images of the right knee surface of rabbits on day 28.…”

Section: Nanotechnology-based Treatment Approaches For Asmentioning

confidence: 99%

<p>Advances in nanomedicine for the treatment of ankylosing spondylitis</p>

Xi¹,

Jiang²,

Chaurasiya³

et al. 2019

IJN

View full text Add to dashboard Cite

Ankylosing spondylitis (AS) is a complex disease characterized by inflammation and ankylosis primarily at the cartilage–bone interface. The disease is more common in young males and risk factors include both genetic and environmental. While the pathogenesis of AS is not completely understood, it is thought to be an immune-mediated disease involving inflammatory cellular infiltrates, and human leukocyte antigen-B27. Currently, there is no specific diagnostic technique available for this disease; therefore conventional diagnostic approaches such as clinical symptoms, laboratory tests and imaging techniques are used. There are various review papers that have been published on conventional treatment approaches, and in this review work, we focus on the more promising nanomedicine-based treatment modalities to move this field forward.

show abstract

Chitosan based thermosensitive injectable hydrogels for controlled delivery of loxoprofen: development, characterization and in-vivo evaluation

Cited by 67 publications

References 52 publications

Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier

Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier

Multifunctional Biopolymers‐Based Composite Materials for Biomedical Applications: A Systematic Review

<p>Advances in nanomedicine for the treatment of ankylosing spondylitis</p>

Contact Info

Product

Resources

About