Chitosan-based therapeutic systems and their potentials in treatment of oral diseases

Gao, Hongyu; Wu, Nan; Wang, Nini; Li, Jie; Peng, Qiang

doi:10.1016/j.ijbiomac.2022.10.090

Cited by 22 publications

(5 citation statements)

References 210 publications

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“…Due to the positively charged amine groups and their strong interaction with bacterial cell membranes, CMC exhibits antibacterial activity. 116 Meanwhile, CMC could serve as a long-term platform for stem cell culture, promoting osteogenic differentiation of mesenchymal stem cells by stimulating Wnt3a and ERK1/2 pathways. 117 Therefore, the OPC hydrogel possesses numerous biological functions.…”

Section: Discussionmentioning

confidence: 99%

A whole-course-repair system based on ROS/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats

Feng,

Zhang,

Zhang

et al. 2024

J. Mater. Chem. B

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Section: Discussionmentioning

confidence: 99%

A whole-course-repair system based on ROS/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats

Feng,

Zhang,

Zhang

et al. 2024

J. Mater. Chem. B

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“…Chitosan has intrinsic antimicrobial activity and controlled drug-release properties. Thus, its use as an antimicrobial agent, drug delivery carrier, and tissue-engineered scaffold in the management of periodontal disorders can significantly improve the therapeutic effect on the disease. , Chitosan has antimicrobial activity against the key periodontal pathogens, P. gingivalis and Streptococcus pyogenes , and against most Gram-negative and Gram-positive bacteria . A potential antibacterial mechanism of chitosan lies in its abundance of positively charged amine groups, which interact with negatively charged lipids, proteins, and polysaccharides on the surface of the bacterial cell membrane.…”

Section: The Fundamental Components Of Hydrogels In Periodontal Treat...mentioning

confidence: 99%

Advances in Hydrogels for Periodontitis Treatment

Li,

Wang,

Xiao

et al. 2024

ACS Biomater. Sci. Eng.

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Periodontitis is a common condition characterized by a bacterial infection and the disruption of the body's immune-inflammatory response, which causes damage to the teeth and supporting tissues and eventually results in tooth loss. Current therapy involves the systemic and local administration of antibiotics. However, the existing treatments cannot exert effective, sustained release and maintain an effective therapeutic concentration of the drug at the lesion site. Hydrogels are used to treat periodontitis due to their low cytotoxicity, exceptional water retention capability, and controlled drug release profile. Hydrogels can imitate the extracellular matrix of periodontal cells while offering suitable sites to load antibiotics. This article reviews the utilization of hydrogels for periodontitis therapy based on the pathogenesis and clinical manifestations of the disease. Additionally, the latest therapeutic strategies for smart hydrogels and the main techniques for hydrogel preparation have been discussed. The information will aid in designing and preparing future hydrogels for periodontitis treatment.

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“…Therefore, the prevention and treatment of these oral illnesses have thus received significant attention [3]. Oral diseases are pathological changes that occur in the soft and hard structures of the oral cavity and maxillofacial region [4]. The most common oral diseases include dental caries, periodontitis, pulp necrosis, oral mucositis, and jaw abnormalities [5].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for Oral Tissue Engineering: Challenges and Opportunities

Chen,

Deng,

Lai

et al. 2023

Molecules

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Oral health is crucial to daily life, yet many people worldwide suffer from oral diseases. With the development of oral tissue engineering, there is a growing demand for dental biomaterials. Addressing oral diseases often requires a two-fold approach: fighting bacterial infections and promoting tissue growth. Hydrogels are promising tissue engineering biomaterials that show great potential for oral tissue regeneration and drug delivery. In this review, we present a classification of hydrogels commonly used in dental research, including natural and synthetic hydrogels. Furthermore, recent applications of these hydrogels in endodontic restorations, periodontal tissues, mandibular and oral soft tissue restorations, and related clinical studies are also discussed, including various antimicrobial and tissue growth promotion strategies used in the dental applications of hydrogels. While hydrogels have been increasingly studied in oral tissue engineering, there are still some challenges that need to be addressed for satisfactory clinical outcomes. This paper summarizes the current issues in the abovementioned application areas and discusses possible future developments.

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Chitosan-based therapeutic systems and their potentials in treatment of oral diseases

Cited by 22 publications

References 210 publications

A whole-course-repair system based on ROS/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats

A whole-course-repair system based on ROS/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats

Advances in Hydrogels for Periodontitis Treatment

Hydrogels for Oral Tissue Engineering: Challenges and Opportunities

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