Chitosan‐Based Systems for Mucosal Delivery of Biopharmaceuticals

Al‐Qadi, Sonia; Grenha, Ana; Remuñán‐López, Carmen

doi:10.1002/9781119962977.ch11

Cited by 1 publication

(1 citation statement)

References 179 publications

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“…Studies have shown that these nanoparticles enhance drug absorption, promote mucosal immunisation and gene expression. Chitosan-hybrids NPs have been used as carriers as these particles protect the entrapped biopharmaceuticals from degradation, improve cellular uptake and can be delivered via diff erent administration routes (oral, nasal and pulmonary) [119]. Triggered release is also an important point to consider when designing delivery agents.…”

Section: Targeted Delivery Agentsmentioning

confidence: 99%

Chitosan as an Advanced Healthcare Material

Jardine

Sayed

2014

Advanced Biomaterials and Biodevices

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Chitin and chitosan are renewable biopolymers with inherently favourable properties allowing diverse chemical modifi cation that generates novel materials ideal for biomedical applications. Chitin itself has very poor aqueous solubility and hence found limited utility. For this reason the use of chitosan, in particular, modifi ed chitosan, has increased exponentially in biomedical applications in recent years. Th e review of chitosan as a health care material includes wound healing or tissue regeneration, drug delivery and antimicrobial studies. Specialist applications are vast and due to the shortened publication process, biomedical applications of chitosan may warrant more frequent reviews.In this review, highlights of recent research on the synthesis and analysis of chitin and chitosan based nanomaterials and nanofi bres will be covered. A detailed review of the synthetic transformation of chitosan that further added value by enabling diverse application has been discussed. Th e value of copolymerization and graft ing of biodegradable synthetic polymers with chitosan in order to improve stability and control of the functional biomaterial has been a major driver in the biotechnological innovation.

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Section: Targeted Delivery Agentsmentioning

confidence: 99%