Chitosan-based scaffolds for growth factor delivery

Gohil, Shalini V.; Padmanabhan, Aiswaria; Deschamps, Jessica; Nair, Lakshmi S.

doi:10.1016/b978-0-08-100228-5.00007-9

Cited by 10 publications

(15 citation statements)

References 143 publications

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“…Nonetheless, cellulose hydrogels show restricted mechanical attributes that hold back their utilization in hard tissue applications. To surpass this limitation of cellulose-based scaffolds and to build on the functional properties for hard tissue application, mineralization of cellulose hydrogels with HAp and other materials has been actively investigated in recent years [ 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 ]. Bacterial cellulose was successfully combined with HAp to deliver BMP-2 [ 94 ].…”

Section: Polymer Scaffolds For Gf Deliverymentioning

confidence: 99%

“…Chitin–chitosan is a nitrogen-containing polysaccharide-based biopolymer group derived from diverse natural raw materials such as fungi, crustaceans, and insects [ 96 , 97 ]. Chitin and chitosan are structurally similar to glycosaminoglycans (GAGs, the major component of the bone ECM), which make them suitable biopolymers for tissue engineering scaffolds [ 96 , 97 , 98 ]. Chitin used in combination with chitosan/poly(vinyl alcohol) to fabricate nanofibers showed enhanced mechanical properties and offered osteoblast cell growth with HAp biomineralization [ 99 ].…”

Section: Polymer Scaffolds For Gf Deliverymentioning

confidence: 99%

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Advances in Growth Factor Delivery for Bone Tissue Engineering

Oliveira

Nie

Podstawczyk

et al. 2021

IJMS

105

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Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues. Although recent studies on developing novel growth factor delivery systems for bone repair have attracted great attention, taking into account the complexity of the extracellular matrix, scaffolding and growth factors should not be explored independently. Consequently, systems that combine both concepts have great potential to promote the effectiveness of bone regeneration methods. In this review, recent developments in bone regeneration that simultaneously consider scaffolding and growth factors are covered in detail. The main emphasis in this overview is on delivery strategies that employ polymer-based scaffolds for spatiotemporal-controlled delivery of both single and multiple growth factors in bone-regeneration approaches. From clinical applications to creating alternative structural materials, bone tissue engineering has been advancing constantly, and it is relevant to regularly update related topics.

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Section: Polymer Scaffolds For Gf Deliverymentioning

confidence: 99%

Section: Polymer Scaffolds For Gf Deliverymentioning

confidence: 99%

Advances in Growth Factor Delivery for Bone Tissue Engineering

Oliveira

Nie

Podstawczyk

et al. 2021

IJMS

105

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“…The presence of amino and hydroxyl functional groups in chitosan plays an important role in the release of growth factors in the extracellular matrix. Chitosan combines with negatively charged biomolecules through electrostatic action of positive charge generated by amino protonation in the chain to control the release of encapsulating proteins (Gohil et al, 2017). Additionally, Song et al (Oh & Lee, 2019) indicated that the combination of chitosan and silica dressing loaded with keratinocyte growth factor (KGF) had the characteristics of continuous KGF release.…”

Section: Chitosan and Chitinmentioning

confidence: 99%

Engineered biomaterial strategies for controlling growth factors in tissue engineering

et al. 2020

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Growth factors are multi-functional signaling molecules that coordinate multi-stage process of wound healing. During wound healing, growth factors are transmitted to wound environment in a positive and physiologically related way, therefore, there is a broad prospect for studying the mediated healing process through growth factors. However, growth factors (GFs) themselves have disadvantages of instability, short life, rapid inactivation of physiological conditions, low safety and easy degradation, which hinder the clinical use of GFs. Rapid development of delivery strategies for GFs has been trying to solve the instability and insecurity of GFs. Particularly, in recent years, GFs delivered by scaffolds based on biomaterials have become a hotspot in this filed. This review introduces various delivery strategies for growth factors based on new biodegradable materials, especially polysaccharides, which could provide guidance for the development of the delivery strategies for growth factors in clinic.

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“…Для гидрогелей (а также и других типов СДФР) часто используется хитозан -природный полисахарид с гемостатическими и бактериостатическими свойствами. Присутствие хитозана в раневом ложе стимулирует пролиферацию клеток, а также образование коллагена и гиалуроновой кислоты [45]. Alemdaroğlu C. и соавт.…”

Section: структура матрицы нано-и микрочастицыunclassified

Molecular systems for targeted delivery and controlled release of growth factors for chronic wound treatment

Липунов

Afanasov

Воробьева³

et al. 2020

Rany i ranevye infekcii

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Growth factors (GFs) are endogenous signaling proteins, that regulate cell migration, proliferation and differentiation in tissue regeneration. GFs’ concentrations in chronic wounds are pathologically reduced. This leads to a disruption of the healing process and makes chronic wounds treatment more complicated. There are drugs currently used in clinical practice, that contain GFs in a free form. However, their efficiency for chronic wounds treatment is limited, as GFs are quickly degraded in a proteolytic environment of chronic wounds. In order to overcome this limitation biocompatible molecular systems for targeted delivery and controlled release are proposed, such as: micro- and nanoparticles, hydrogels, scaffolds. GFs roles in the healing process, chronic wounds pathophysiology and molecular systems for GFs targeted delivery and controlled release are reviewed.

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Chitosan-based scaffolds for growth factor delivery

Cited by 10 publications

References 143 publications

Advances in Growth Factor Delivery for Bone Tissue Engineering

Advances in Growth Factor Delivery for Bone Tissue Engineering

Engineered biomaterial strategies for controlling growth factors in tissue engineering

Molecular systems for targeted delivery and controlled release of growth factors for chronic wound treatment

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