Chitosan-based nanosystems and their exploited antimicrobial activity

Perinelli, Diego Romano; Fagioli, Laura; Campana, Raffaella; Lam, Jenny K.W.; Baffone, Wally; Palmieri, Gianni; Casettari, Luca

doi:10.1016/j.ejps.2018.01.046

Cited by 204 publications

(94 citation statements)

References 124 publications

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“…Chitosan is a polysaccharide formed by a randomly distributed β-(1→4)-linked D-glucosamine and N-acetyl-D-glucosamine monomers. The chitosan types differ in molecular weight, degree and pattern of N-acetylation [62]. They are obtained by the process of alkaline deacetylation of chitin [63].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…The chitosan pKa is approximately 6.5, being soluble in acid medium and insoluble in alkaline and neutral media [63]. Chitosan has been investigated for use in several areas such as food, cosmetic, pharmaceutical and agrochemical industries [34,44,62,[65][66][67]. Chitosan is non-toxic, biocompatible, biodegradable [63], has antimicrobial activity, and low immunogenicity while properties like mucoadhesion, controlled drug delivery, and in situ gelation improve permeation [68].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

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New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

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Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

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“…In recent study, chitosan shows potential anti-QS activity by disturbing biofilm formation and inhibiting C. violaceum violacein production [21]. Chitosan-based nanomaterials have also shown biological activities against microorganisms, including bacteria and fungi activity [22,23]. Recent studies have shown that the enhanced antimicrobial activity of chitosan-based NPs is related to the increase of surface area to volume ratio as the particle size decreases [63,64].…”

Section: Introductionmentioning

confidence: 99%

Chitosan encapsulation modulates the effect of trans-cinnamaldehyde on AHL-regulated quorum sensing activity

Qin

Kräft

Goycoolea

2018

Colloids and Surfaces B: Biointerfaces

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“…An optimal localized treatment of vaginal infections depends not only on the potency of the active ingredient/drug, but also on the physiochemical properties of the formulation; an ideal formulation can protect and enhance as well as act in synergy with antimicrobial to assure successful therapy [23]. Chitosan-based delivery systems exhibit strong mucoadhesive properties, an excellent safety profile and intrinsic antimicrobial activity of chitosan, which add to their attractiveness as pharmaceutical formulations, including those destined for vaginal delivery [4,17,24,25]. However, relatively little is known about the effects of the type of formulation on the antimicrobial performance of the formulation.…”

Section: Resultsmentioning

confidence: 99%

The Antimicrobial Properties of Chitosan Can Be Tailored by Formulation

et al. 2020

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Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in improving localized vaginal therapy by prolonging the residence time of a drug at the vaginal site while acting as an antimicrobial in synergy. Therefore, we aimed to explore the potential of chitosan, namely chitosan-coated liposomes and chitosan hydrogel, as an excipient with intrinsic antimicrobial properties. Liposomes were prepared by the thin-film hydration method followed by vesicle size reduction by sonication to the desired size, approximately 200 nm, and coated with chitosan (0.01, 0.03, 0.1, and 0.3%, w/v, respectively). The mucoadhesive properties of chitosan-coated liposomes were determined through their binding efficiency to mucin compared to non-coated liposomes. Non-coated liposomal suspensions were incorporated in chitosan hydrogels forming the liposomes-in-hydrogel formulations, which were further assessed for their texture properties in the presence of biological fluid simulants. The antibacterial effect of chitosan-coated liposomes (0.03%, 0.1% and 0.3%, w/v) and chitosan hydrogels (0.1% and 0.3%, w/w) on Staphylococcus epidermidis and Staphylococcus aureus was successfully confirmed.

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Chitosan-based nanosystems and their exploited antimicrobial activity

Cited by 204 publications

References 124 publications

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Chitosan encapsulation modulates the effect of trans-cinnamaldehyde on AHL-regulated quorum sensing activity

The Antimicrobial Properties of Chitosan Can Be Tailored by Formulation

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