Chitosan-based nanoscale delivery systems in hepatocellular carcinoma: Versatile bio-platform with theranostic application

Karimi, Kimia; Mojtabavi, Sarah; Tehrany, Pooya M.; Nejad, Melina Maghsodlou; Rezaee, Aryan; Mohtashamian, Shahab; Hamedi, Erfan; Yousefi, Farnaz; Salmani, Farshid; Zandieh, Mohammad Arad; Nabavi, Noushin; Rabiee, Navid; Ertas, Yavuz Nuri; Salimimoghadam, Shokooh; Rashidi, Mohsen; Rahmanian, Parham; Hushmandi, Kiavash; Yu, Wei

doi:10.1016/j.ijbiomac.2023.124935

Cited by 6 publications

(2 citation statements)

References 178 publications

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“…There are three main types of chitins, referred to as α-chitin, β-chitin, and γ-chitin, based on the arrangement of the polymer chains [ 46 ]: α-chitin, which showed antiparallel arrangements of polymer chains; β-chitin, which showed parallel arrangements of polymer chains; γ-chitin, which showed irregular arrangements of polymer chains. Generally, a pH fluctuation can degrade the chitosan NPs, while different modifications have increased the stability of chitosan [ 47 ]. The biodegradability of chitosan can be increased through the physical ionic gelation method by using polyanionic materials, such as tripolyphosphate (TPP) [ 48 ].…”

Section: Biological Importance Of Chitosanmentioning

confidence: 99%

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Imran,

Tang,

Wang

et al. 2023

Molecules

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Chitosan nanoparticles (NPs) serve as useful multidrug delivery carriers in cancer chemotherapy. Chitosan has considerable potential in drug delivery systems (DDSs) for targeting tumor cells. Doxorubicin (DOX) has limited application due to its resistance and lack of specificity. Chitosan NPs have been used for DOX delivery because of their biocompatibility, biodegradability, drug encapsulation efficiency, and target specificity. In this review, various types of chitosan derivatives are discussed in DDSs to enhance the effectiveness of cancer treatments. Modified chitosan–DOX NP drug deliveries with other compounds also increase the penetration and efficiency of DOX against tumor cells. We also highlight the endogenous stimuli (pH, redox, enzyme) and exogenous stimuli (light, magnetic, ultrasound), and their positive effect on DOX drug delivery via chitosan NPs. Our study sheds light on the importance of chitosan NPs for DOX drug delivery in cancer treatment and may inspire the development of more effective approaches for cancer chemotherapy.

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Section: Biological Importance Of Chitosanmentioning

confidence: 99%

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Imran,

Tang,

Wang

et al. 2023

Molecules

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“…Recent developments in molecular biology, particularly in viral vectors and genome‐editing techniques, have significantly enhanced the accuracy and effectiveness of gene therapy interventions. 2 , 3 , 4 , 5 This has resulted in previously incurable genetic disorders being treated with potential hope for patients and their families. However, developing safe and effective gene therapies has been challenging.…”

Section: Introductionmentioning

confidence: 99%

Nanoliposomes as nonviral vectors in cancer gene therapy

Yildiz,

Entezari,

Paskeh

et al. 2024

MedComm

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Nonviral vectors, such as liposomes, offer potential for targeted gene delivery in cancer therapy. Liposomes, composed of phospholipid vesicles, have demonstrated efficacy as nanocarriers for genetic tools, addressing the limitations of off‐targeting and degradation commonly associated with traditional gene therapy approaches. Due to their biocompatibility, stability, and tunable physicochemical properties, they offer potential in overcoming the challenges associated with gene therapy, such as low transfection efficiency and poor stability in biological fluids. Despite these advancements, there remains a gap in understanding the optimal utilization of nanoliposomes for enhanced gene delivery in cancer treatment. This review delves into the present state of nanoliposomes as carriers for genetic tools in cancer therapy, sheds light on their potential to safeguard genetic payloads and facilitate cell internalization alongside the evolution of smart nanocarriers for targeted delivery. The challenges linked to their biocompatibility and the factors that restrict their effectiveness in gene delivery are also discussed along with exploring the potential of nanoliposomes in cancer gene therapy strategies by analyzing recent advancements and offering future directions.

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Autophagy flux in bladder cancer: Cell death crosstalk, drug and nanotherapeutics

Liu,

Chen,

et al. 2024

Cancer Letters

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Chitosan-based nanoscale delivery systems in hepatocellular carcinoma: Versatile bio-platform with theranostic application

Cited by 6 publications

References 178 publications

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Nanoliposomes as nonviral vectors in cancer gene therapy

Autophagy flux in bladder cancer: Cell death crosstalk, drug and nanotherapeutics

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