Chitosan-based nanoparticles: An overview of biomedical applications and its preparation

Naskar, Sweet; Sharma, Suraj; Kuotsu, Ketousetuo

doi:10.1016/j.jddst.2018.10.022

Cited by 172 publications

(74 citation statements)

References 219 publications

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“…The preparation of chitosan modified magnetic nanoparticles is of great interest to researchers [ 10 , 11 ]. This polymer has been used successfully to colloidally stabilize metal oxide nanoparticles, and it has also been used as a matrix for enzyme immobilization through numerous amino groups, which interact with enzymes as shown in Figure 1 [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Chitosan Functionalized Magnetic Nanoparticles with Bioactive Compounds

2020

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In this study, magnetic maghemite nanoparticles, which belong to the group of metal oxides, were functionalized with chitosan, a non-toxic, hydrophilic, biocompatible, biodegradable biopolymer with anti-bacterial effects. This was done using different synthesis methods, and a comparison of the properties of the synthesized chitosan functionalized maghemite nanoparticles was conducted. Characterization was performed using scanning electron microscopy (SEM) and vibrating sample magnetometry (VSM). Characterizations of size distribution were performed using dynamic light scattering (DLS) measurements and laser granulometry. A chitosan functionalization layer was confirmed using potentiometric titration on variously synthesized chitosan functionalized maghemite nanoparticles, which is important for further immobilization of bioactive compounds. Furthermore, after activation of chitosan functionalized maghemite nanoparticles with glutaraldehyde (GA) or pentaethylenehexamine (PEHA), immobilization studies of enzyme cholesterol oxidase (ChOx) and horseradish peroxidase (HRP) were conducted. Factors influencing the immobilization of enzymes, such as type and concentration of activating reagent, mass ratio between carrier and enzyme, immobilization time and enzyme concentration, were investigated. Briefly, microparticles made using the chitosan suspension cross-linking process (MC2) proved to be the most suitable for obtaining the highest activity of immobilized enzyme, and nanoparticles functionalized with chitosan using the covalent binding method (MC3) could compete with MC2 for their applications.

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Section: Introductionmentioning

confidence: 99%

Development of Chitosan Functionalized Magnetic Nanoparticles with Bioactive Compounds

2020

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“…Among natural polymers, chitosan (CS), a linear polysaccharide composed of randomly distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine, has currently gained great attention for different applications in the biomedical field and particularly to design drug delivery systems [12]. CS is a renewable and sustainable cationic biopolymer derived from alkaline partial deacetylation of chitin, one of the most abundant biopolymers in nature and acquired from crustacean and insect exoskeletons.…”

Section: Introductionmentioning

confidence: 99%

“…The conventional preparation techniques for CS NPs cover bulk methods based on emulsification and chemical cross-linking, emulsion droplet coalescence, emulsion solvent diffusion, reverse micellization, desolvation, ionic gelation and polyelectrolyte complexation or a combination of both [12,19]. All bulk techniques for CS NPs synthesis consist of bottom-up approaches based on the controlled assembly of molecular components forming a system with a complex structural design [4].…”

Section: Introductionmentioning

confidence: 99%

Staggered Herringbone Microfluid Device for the Manufacturing of Chitosan/TPP Nanoparticles: Systematic Optimization and Preliminary Biological Evaluation

Chiesa

Greco

Riva

et al. 2019

IJMS

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Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge in the application of CS NPs was faced during their size-controlled synthesis. Herein, ionic gelation reaction between CS and sodium tripolyphosphate (TPP), a widely used and safe CS cross-linker for biomedical application, was exploited by a microfluidic approach based on a staggered herringbone micromixer (SHM) for the synthesis of TPP cross-linked CS NPs (CS/TPP NPs). Screening design of experiments was applied to systematically evaluate the main process and formulative factors affecting CS/TPP NPs physical properties (mean size and size distribution). Effectiveness of the SHM-assisted manufacturing process was confirmed by the preliminary evaluation of the biological performance of the optimized CS/TPP NPs that were internalized in the cytosol of human mesenchymal stem cells through clathrin-mediated mechanism. Curcumin, selected as a challenging model drug, was successfully loaded into CS/TPP NPs (EE% > 70%) and slowly released up to 48 h via the diffusion mechanism. Finally, the comparison with the conventional bulk mixing method corroborated the efficacy of the microfluidics-assisted method due to the precise control of mixing at microscales.

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“…Additionally, due to the availability of functional groups, chitosan can be modified in different ways to obtain substituted, crosslinked, carboxylated, ionic and bounded derivatives to match the various research needs [ 2 ]. The different methods utilized in synthesizing chitosan-based nanoparticles, such as emulsion crosslinking, emulsion-droplet coalescence, ionotropic gelation, reverse micellisation, and precipitation, have been described in detail in the literature [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

et al. 2020

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Chitosan has emerged as a biodegradable, nontoxic polymer with multiple beneficial applications in the agricultural and biomedical sectors. As nanotechnology has evolved as a promising field, researchers have incorporated chitosan-based nanomaterials in a variety of products to enhance their efficacy and biocompatibility. Moreover, due to its inherent antimicrobial and chelating properties, and the availability of modifiable functional groups, chitosan nanoparticles were also directly used in a variety of applications. In this review, the use of chitosan-based nanomaterials in agricultural and biomedical fields related to the management of abiotic stress in plants, water availability for crops, controlling foodborne pathogens, and cancer photothermal therapy is discussed, with some insights into the possible mechanisms of action. Additionally, the toxicity arising from the accumulation of these nanomaterials in biological systems and future research avenues that had gained limited attention from the scientific community are discussed here. Overall, chitosan-based nanomaterials show promising characteristics for sustainable agricultural practices and effective healthcare in an eco-friendly manner.

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Chitosan-based nanoparticles: An overview of biomedical applications and its preparation

Cited by 172 publications

References 219 publications

Development of Chitosan Functionalized Magnetic Nanoparticles with Bioactive Compounds

Development of Chitosan Functionalized Magnetic Nanoparticles with Bioactive Compounds

Staggered Herringbone Microfluid Device for the Manufacturing of Chitosan/TPP Nanoparticles: Systematic Optimization and Preliminary Biological Evaluation

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

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