Chitosan based nanofibers in bone tissue engineering

Balagangadharan, K.; Thangaraj, Parimelazhagan; Selvamurugan, N.

doi:10.1016/j.ijbiomac.2016.12.046

Cited by 221 publications

(119 citation statements)

References 107 publications

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“… Physically, nanofibers provide high porosity and surface area to facilitate transportation of nutrients and cell attachment . A natural polymer also has a good degradation property to comply with the implant material while a synthetic polymer provides a structural integrity to the nanofiber scaffold to survive in various condition and load bearing . Many authors have developed composite natural‐synthetic nanofibers such as poly(L‐lactide acid) (PLLA)/Collagen, PLLA/Chitosan, and poly‐ɛ‐caprolactone/chitosan .…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Yusof

Shamsudin

Abdullah

et al. 2018

Polymers for Advanced Techs

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Carboxymethyl starch (CMS) is a natural polymer derived from sago starch that is obtained from sago palm (Metroxylon spp.). Herein, CMS was used as a polysaccharide source in preparations of composite nanofibers with poly(L‐lactide acid) (PLLA). The incorporation of CMS with PLLA in nanofiber form has great potential to be used in biomedical applications. The composite PLLA/CMS nanofibers were fabricated by electrospinning technique at various ratios of CMS, which were 5, 10, 15, and 20% vol/vol. The composite nanofibers were characterized according to their physical morphology, chemical interaction, wettability, water uptake, and thermal and mechanical behaviors. The result showed that uniform and bead‐free nanofibers were produced at the low ratio of CMS while fractal and discontinuing fiber was observed at a high ratio of CMS. A better mechanical strength was obtained at low CMS ratio as compared with higher one. Fourier transform infrared results showed that there was an interaction between CMS and PLLA after electrospinning. The surface hydrophilicity and water uptake increased with increasing ratio of CMS. The results from the differential scanning calorimeter analysis showed the decrease of the glass transition (Tg) and cold crystallization temperature (Tcc) of the nanofiber after addition of CMS in PLLA.

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Section: Introductionmentioning

confidence: 99%

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Yusof

Shamsudin

Abdullah

et al. 2018

Polymers for Advanced Techs

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“…Chitosan is widely used in medicine, food, and many other areas because of its characteristics as a drug carrier or accessory . Many studies on Chitosan and CPC composites show that Chitosan combined with CPC can improve the CPC surface brittleness . Therefore, in this study, Chitosan was added to coat the surface of bone cement that was penetrated with CGRP.…”

Section: Discussionmentioning

confidence: 99%

Novel calcitonin gene‐related peptide/chitosan‐strontium‐calcium phosphate cement: Enhanced proliferation of human umbilical vein endothelial cells in vitro

Liang

et al. 2018

J Biomed Mater Res

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Bone cement materials have some disadvantages, including slow degradation and no biological activity, which greatly weakens their clinical application. Therefore, the search for a multifunctional bioactive bone cement has become urgent. In this study, a novel bone cement sample of calcitonin gene-related peptide (CGRP)/chitosan-strontium (Sr)-calcium phosphate cement (CPC) was developed. The structure and morphology were observed by scanning electron microscope (SEM). The cytotoxicity and proliferation of CGRP/chitosan-Sr-CPC were also measured. The expression of CGRP receptor 1 was measured using an immunofluorescence assay. Real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) were employed to quantify the VEGF mRNA and protein levels, respectively. Finally, the ability of the material to improve angiogenesis was assessed by using human umbilical vein endothelial cells (HUVECs) tube formation assay. The results showed that CGRP/Chitosan-Sr-CPC had the characteristics of a good orthopedic material without showing cell cytotoxicity to HUVECs. Meanwhile, CGRP/chitosan-Sr-CPC could release CGRP and enhance the proliferation of HUVECs via CGRP receptors. Moreover, CGRP/chitosan-Sr-CPC significantly upregulated the expression of the VEGF gene and protein in HUVECs, which might help improve the angiogenesis microenvironment. Besides, CGRP/chitosan-Sr-CPC could significantly improve angiogenesis of HUVECs. These findings provide new therapeutic material for the treatment of osteoporotic bone injury. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

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“…It has structural and compositional similarity to glycosaminoglycans and therefore produces a minimal immune response . CS has properties such as biocompatibility and biodegradability . It can be processed into porous structures and films for application in tissue regeneration, wound dressings, and drug delivery systems .…”

Section: Introductionmentioning

confidence: 99%

Chitosan in Surface Modification for Bone Tissue Engineering Applications

Abinaya

Prasith

Ashwin

et al. 2019

Biotechnology Journal

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Traditional methods of bone defect repair include autografts, allografts, surgical reconstruction, and metal implants that have several disadvantages such as donor site morbidity, rejection, risk of disease transmission, and repetitive surgery. Biomaterial‐based bone reconstructions can, therefore, be an efficient alternative due to the inherent properties of the materials. Chitosan (CS), the deacetylated form of chitin, is a biopolymer having a wide array of applicability in regenerative tissue applications owing to its biocompatible, in vitro degradative and bioresorbable nature. Extensive studies are being carried out using CS to augment the properties of the already existing methods and to also improve the applicability of CS‐based biocomposites in bone tissue repair. In this review, the suitability of CS as a surface modifier has been discussed in detail for the already existing implants, surface modifications of CS‐based natural biocomposites for bone tissue regeneration, and the wide range of techniques that can introduce these modifications. CS, being a natural polymer, possesses advantageous properties including surface modifier that makes it a suitable candidate for bone regeneration, and further research to investigate its osteogenic potential in vivo along with the molecular and signaling mechanisms involved in bone regeneration can aid in expanding its applicability in clinical trials.

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Chitosan based nanofibers in bone tissue engineering

Cited by 221 publications

References 107 publications

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Novel calcitonin gene‐related peptide/chitosan‐strontium‐calcium phosphate cement: Enhanced proliferation of human umbilical vein endothelial cells in vitro

Chitosan in Surface Modification for Bone Tissue Engineering Applications

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