Chitosan-based nano-in-microparticle carriers for enhanced oral delivery and anticancer activity of propolis

Elbaz, Nancy M.; Khalil, Islam A.; Abdrabou, Ahmed; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.ijbiomac.2016.07.024

Cited by 92 publications

(51 citation statements)

References 31 publications

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“…[281,282] The results found by several research teams [279 -283] supported the data cited above for other propolis originated from the countries of the Mediterranean Sea, which were characterized by their high antitumor capacity. Beyond that, Elbaz et al [283] have constructed a new formulated propolis-loaded nano-in-microparticles (NIMs) for enhancing its anticancer property and oral delivery against human liver cancer (HepG2) and human colorectal cancer (HCT 116) cells. This research highlighted that propolis-loaded NIMs induced more cytotoxic effect on HepG2 cells than HCT-116 cells, present three-fold higher therapeutic efficiency than free propolis and leads to the apoptosis of HepG2 cells, moreover, it increases propolis solubility with a controlling release profile in different gastrointestinal tract environments.…”

Section: Application In Medicine Pharmacy and Bio-allied Sciencementioning

confidence: 99%

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

El-Guendouz

Lyoussi

Miguel

2019

Chemistry & Biodiversity

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This review updates the information upon the chemical composition of propolis from all Mediterranean countries as well as their biological properties and applications. The non‐volatile fraction of propolis was characterized by the presence of phenolic acids and their esters and flavonoids. Nevertheless, in some countries, diterpenes were also present: Sicily (Italy), Croatia, Malta, Creta (Greece), Turkey, Cyprus, Egypt, Libya, Algeria and Morocco. The volatile fraction of propolis was characterized by the presence of benzoic acid and its esters, mono‐ and sesquiterpenes, being the oxygenated sesquiterpene β‐eudesmol characteristic of poplar propolis, whereas the hydrocarbon monoterpene α‐pinene has been related with the presence of conifers. Regardless the chemical composition, there are common biological properties attributed to propolis. Owing to these attributes, propolis has been target of study for applications in diverse areas, such as food, medicine and livestock.

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Section: Application In Medicine Pharmacy and Bio-allied Sciencementioning

confidence: 99%

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

El-Guendouz

Lyoussi

Miguel

2019

Chemistry & Biodiversity

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“…Elbaz, Khalil, Abd‐Rabou, and El‐Sherbiny () used Cs microparticles to stabilize propolis NPs. The self‐assembly of Cs/propolis was carried out by means of the nanoprecipitation method.…”

Section: Potential Applications Of Scps In Foodmentioning

confidence: 99%

“…Huang and Zhou (2014) and Sun, Saldaña, Zhao, Wu, and Dong (2016), for example, have used peach gum and iota-carrageenan, respectively, to encapsulate hydrophobic compounds by self-assembly. Elbaz, Khalil, Abd-Rabou, and El-Sherbiny (2016) used Cs microparticles to stabilize propolis NPs. The self-assembly of Cs/propolis was carried out by means of the nanoprecipitation method.…”

Section: Encapsulationmentioning

confidence: 99%

“…The self-assembly of Cs/propolis was carried out by means of the nanoprecipitation method. These authors observed a considerable improvement in the propolis solubility with a controlled release profile in different gastrointestinal tract environments (Elbaz et al, 2016). Yang et al (2016) self-assembled β-carotene/LA-graft-HEC NPs via sonication-dialysis method.…”

Section: Encapsulationmentioning

confidence: 99%

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Self‐Assembled Carbohydrate Polymers for Food Applications: A Review

Valencia

Zare‬

Makvandi

et al. 2019

Comp Rev Food Sci Food Safe

103

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The self‐assembled natural and synthetic polymers are booming. However, natural polymers obtained from native or modified carbohydrate polymers (CPs), such as celluloses, chitosan, glucans, gums, pectins, and starches, have had special attention as raw material in the manufacture of self‐assembled polymer composite materials having several forms: films, hydrogels, micelles, and particles. The easy manipulation of the architecture of the CPs, as well as their high availability in nature, low cost, and being sustainable and green polymers have been the main positive points in the use of them for different applications. CPs have been used as building blocks for composite structures, and their easy orientation and ordering has given rise to self‐assembled CPs (SCPs). These macromolecules have been little studied for food applications. Nonetheless, their research has grown mainly in the last 5 years as encapsulated food additive wall materials, food coatings, and edible films. The multifaceted properties (systems sensitive to pH, temperature, ionic strength, types of ions, mechanical force, and enzymes) of these devices are leading to the development of advanced food materials. This review article focused on the analysis of SCPs for food applications in order to encourage other research groups for their preparation and implementation.

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“…Using a microencapsulation method based on casein micelles, Sahlan and Supardi (2013) prepared nano-propolis particles with dimensions ranging between 1.3 m and 300 nm with confirmed antibacterial activity [9]. Elbaz et al (2016) obtained propolis nano-in-microparticles based on chitosan with cytotoxic effects on human liver and colorectal cancer cells (HepG2, HCT 116) that presented three-fold higher anticancer activity than free propolis [10]. Hasan et al (2014) synthesized nanopropolis encapsulated in maltodekstrin with a size of 175 nm, by high speed homogenization combined with solvent evaporation technique; these nanoparticles had also an improved antibacterial activity as compared to the propolis extract, on B. subtilis, S. aureus, E. coli and Salmonella sp.…”

mentioning

confidence: 99%

Formulation and Characterization of Polyurethane Microstructures with Propolis Extract

Duca¹,

Borcan²,

Muntean³

et al. 2019

Mat.Plast.

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Propolis is a natural apicultural product derived from plant resins with impressive health benefits. Its major biologically active substances are barely soluble in water, but this could be increased by proper formulations.The aim of the present study was to obtain a transmembrane delivery system based on polyurethane microstructures for eight propolis samples collected from different regions of Western Romania and to characterize them by differential scanning calorimetry (DSC); the assessed parameters were the particle size, the polydispersity index and their clustering tendency. Polyurethane polymers based on isophorone-diisocyanate and polyethylene glycol 200/ethylene glycol were chosen as carriers for the propolis extract. A perfect inclusion of propolis inside the structures was observed for half of the samples. Particle size ranged between 504 and 621 nm and was confirmed by the low stability against aggregation (Zeta potential: 16.3-19.8 mV). The polydispersity index was between 0.4 and 0.7.

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Chitosan-based nano-in-microparticle carriers for enhanced oral delivery and anticancer activity of propolis

Cited by 92 publications

References 31 publications

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

Self‐Assembled Carbohydrate Polymers for Food Applications: A Review

Formulation and Characterization of Polyurethane Microstructures with Propolis Extract

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