Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review

Li, Aiqin; Ma, Bin; Hua, Shiyao; Ping, Rui; Ding, Lu; Tian, Bingren; Zhang, Xu

doi:10.1016/j.carbpol.2024.121952

Cited by 7 publications

(2 citation statements)

References 158 publications

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“…Apart from adding different synthetic materials, several variables (concentration of CS, the type of crosslinker, the ionic strength of the solution, and pH) can readily affect hydrogel composition and structural networks – it was previously reported that supramolecule addition improved the mechanical and rheological properties. 43,44…”

Section: Hydrogel Sourcesmentioning

confidence: 99%

Recent advances in injectable hydrogel therapies for periodontitis

Ran,

Xue,

Wei

et al. 2024

J. Mater. Chem. B

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Section: Hydrogel Sourcesmentioning

confidence: 99%

Recent advances in injectable hydrogel therapies for periodontitis

Ran,

Xue,

Wei

et al. 2024

J. Mater. Chem. B

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“…Injectable hydrogels may also be utilised in other applications rather than beautifying, such as wound healing, biomedical applications, and the delivering of drugs to targeted sites [7][8][9]. Injectable HA hydrogels are commonly used in various biomedical applications due to their unique properties.…”

Section: Introductionmentioning

confidence: 99%

Novel Injectable Hydrogel Formulations and Gas Chromatography Analysis of the Residual Crosslinker in Formulations Intended for Pharmaceutical and Cosmetic Applications

Rashid,

Carter,

Childs

2024

Gels

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Novel hyaluronic acid (HA) crosslinked with pentaerythritol tetra-acrylate (PT) injectable hydrogels was invented. These injectable hydrogel/dermal filler formulations were synthesised using HA and the acrylate PT as a crosslinker under basic pH conditions using thermal crosslinking methods (oven heating), which provides a simple, safe, and eco-friendly method for crosslinking in 4 h under 45 °C. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) analyses were conducted to represent the difference between the formulations in terms of peak formation and pore size, respectively. The crosslinking was partial as is considered to be typical for dermal injectable fillers. The rheological properties of these formulations showed that these novel dermal injectables are highly promising, and the newly developed fillers could be used with better results for dermal anti-wrinkle corrections, shaping, and volumising reasons. Furthermore, crosslinker (PT) residual analysis was carried out to state the formulations that are valid and acceptable for intradermal usage. The results from the GC method validation revealed it was a suitable method for this study. The GC analysis of all five injectable hydrogel/filler formulations demonstrated the formulations HA-PT 1, 2, 3 and 4 were formulated using (0.05–0.1)% w/w PT containing residual PT monomers within the safe limits that were determined to be below (0.008% w/w). This work has shown the development of a novel injectable hydrogel/filler formulation for pharmaceutical and cosmetic applications can be prepared in a more sustainable and simple way using pentaerythritol tetra-acrylate as a crosslinker agent, which holds great promise for the industry’s future advancement.

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Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications

Yan,

Yang,

Yeh

2024

Chemistry An Asian Journal

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Combining exogenous and endogenous antibacterial mechanisms has been demonstrated to enhance therapeutic efficacy significantly. This study constructs an innovative type of exogenous and endogenous antibacterial nanocomposite hydrogels with injectable dual‐crosslinked networks and dual‐stimuli responsiveness. The primary network establishes imine bonds between the functionalized dextran featuring norbornenes and aldehydes (NorAld‐Dex) and the quaternized chitosan (QCS). The imine bonds provide self‐healing, injectability, and pH‐responsiveness to the hydrogel network. The secondary network is established by integrating thiolated mesoporous silica‐coated titanium dioxide nanoparticles (TiO2@MS‐SH) into the hydrogel network via an ultrasound‐activated thiol‐norbornene reaction with NorAld‐Dex. The microstructures and properties of NorAld‐Dex/QCS/TiO2@MS‐SH hydrogels can be fine‐tuned by adjusting the sonication time to increase the amount of thiol‐norbornene crosslinks in the network. Effective antibacterial performance of NorAld‐Dex/QCS/TiO2@MS‐SH hydrogels at low pH has been demonstrated with the synergistic effect of the acid‐induced dissociation of the hydrogel network, protonated QCS, and the reactive oxygen species (ROS) generated by TiO2@MS‐SH nanoparticles under ultrasound irradiation. In summary, NorAld‐Dex/QCS/TiO2@MS‐SH hydrogel is an advanced dual stimuli‐responsive antibacterial platform with customizable microstructures and properties, offering great potential for biomedical applications.

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Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review

Cited by 7 publications

References 158 publications

Recent advances in injectable hydrogel therapies for periodontitis

Recent advances in injectable hydrogel therapies for periodontitis

Novel Injectable Hydrogel Formulations and Gas Chromatography Analysis of the Residual Crosslinker in Formulations Intended for Pharmaceutical and Cosmetic Applications

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications

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Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review

Cited by 7 publications

References 158 publications

Recent advances in injectable hydrogel therapies for periodontitis

Recent advances in injectable hydrogel therapies for periodontitis

Novel Injectable Hydrogel Formulations and Gas Chromatography Analysis of the Residual Crosslinker in Formulations Intended for Pharmaceutical and Cosmetic Applications

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO2 Nanocomposite Hydrogels for Antibacterial Applications

Contact Info

Product

Resources

About

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications