Chitosan-based hydrogels with injectable, self-healing and antibacterial properties for wound healing

Deng, Pengpeng; Yao, Lichao; Chen, Juanjuan; Tang, Zhigang; Zhou, Jinping

doi:10.1016/j.carbpol.2021.118718

Cited by 100 publications

(58 citation statements)

References 49 publications

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“…Moreover, the new vessels and mature hair follicles could also be observed, which proved that the RCDs-C 35 + L group displayed a better recovery effect. 45,46 Thus, the combination of the antibacterial performance of CAB-35 and the photothermal properties of RCDs made RCDs-C 35 an effective therapeutic agent for bacterial infections.…”

Section: In Vitro Antibacterial Performance Of Rcds-c 35mentioning

confidence: 99%

A multifunctional carbon dot-based nanoplatform for bioimaging and quaternary ammonium salt/photothermal synergistic antibacterial therapy

et al. 2022

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Section: In Vitro Antibacterial Performance Of Rcds-c 35mentioning

confidence: 99%

A multifunctional carbon dot-based nanoplatform for bioimaging and quaternary ammonium salt/photothermal synergistic antibacterial therapy

et al. 2022

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“…After 30 min at room temperature, we observed that the two parts had healed into complete one, which still showed good stretchability (Figure 4B). The self-healing rate is defined as ε = E/E 0 , where E 0 is the initial elongation at break and E is the elongation at break after selfhealing (Deng et al, 2022). After calculation, the self-healing rate of composite hydrogel reached 86.5%.…”

Section: Mechanical Properties Of the Hydrogelsmentioning

confidence: 99%

Highly Transparent, Self-Healing, and Self-Adhesive Double Network Hydrogel for Wearable Sensors

Chen

Liu

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Hydrogel-based flexible electronic devices are essential in future healthcare and biomedical applications, such as human motion monitoring, advanced diagnostics, physiotherapy, etc. As a satisfactory flexible electronic material, the hydrogel should be conductive, ductile, self-healing, and adhesive. Herein, we demonstrated a unique design of mechanically resilient and conductive hydrogel with double network structure. The Ca2+ crosslinked alginate as the first dense network and the ionic pair crosslinked polyzwitterion as the second loose network. With the synthetic effect of these two networks, this hydrogel showed excellent mechanical properties, such as superior stretchability (1,375%) and high toughness (0.57 MJ/m3). At the same time, the abundant ionic groups of the polyzwitterion network endowed our hydrogel with excellent conductivity (0.25 S/m). Moreover, due to the dynamic property of these two networks, our hydrogel also performed good self-healing performance. Besides, our experimental results indicated that this hydrogel also had high optical transmittance (92.2%) and adhesive characteristics. Based on these outstanding properties, we further explored the utilization of this hydrogel as a flexible wearable strain sensor. The data strongly proved its enduring accuracy and sensitivity to detect human motions, including large joint flexion (such as finger, elbow, and knee), foot planter pressure measurement, and local muscle movement (such as eyebrow and mouth). Therefore, we believed that this hydrogel had great potential applications in wearable health monitoring, intelligent robot, human-machine interface, and other related fields.

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“…19,20 Natural honey, 21 essential oils, 22 and chitosans 23 and its modied derivatives such as adenine-modied chitosan (AC) hydrogels displayed excellent antibacterial activities against Gram-negative bacteria, Gram-positive bacteria, fungi, and drug-resistant bacteria. 24 Nevertheless, natural biolms are still found to enhance bacterial tolerance in the presence of chitosans. 25 Honey consists of many active compounds such as avonoids, organic acids, and enzymes that may inhibit bacterial growth; 25 unfortunately, it is not easily modiable.…”

Section: Introductionmentioning

confidence: 99%

“…19,20 Natural honey, 21 essential oils, 22 and chitosans 23 and its modified derivatives such as adenine-modified chitosan (AC) hydrogels displayed excellent antibacterial activities against Gram-negative bacteria, Gram-positive bacteria, fungi, and drug-resistant bacteria. 24…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms of the antibacterial activity of polyimide fibers in a skin-wound model with Gram-positive and Gram-negative bacterial infection in vivo

Yang

Lin

et al. 2022

Nanoscale Adv.

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Chitosan-based hydrogels with injectable, self-healing and antibacterial properties for wound healing

Cited by 100 publications

References 49 publications

A multifunctional carbon dot-based nanoplatform for bioimaging and quaternary ammonium salt/photothermal synergistic antibacterial therapy

A multifunctional carbon dot-based nanoplatform for bioimaging and quaternary ammonium salt/photothermal synergistic antibacterial therapy

Highly Transparent, Self-Healing, and Self-Adhesive Double Network Hydrogel for Wearable Sensors

Molecular mechanisms of the antibacterial activity of polyimide fibers in a skin-wound model with Gram-positive and Gram-negative bacterial infection in vivo

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