Chitosan-based formulation of hemagglutinin antigens for oculo-nasal booster vaccination of chickens against influenza viruses

Sa̧czyńska, Violetta; Romanik-Chruścielewska, Agnieszka; Florys-Jankowska, Katarzyna; Cecuda-Adamczewska, Violetta; Kęsik-Brodacka, Małgorzata

doi:10.1016/j.vetimm.2022.110406

Cited by 3 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, influenza VLP constructs contain hemagglutinin (HA) and matrix protein M1. HA is the primary target antigen for eliciting serological immunity to the influenza virus [ 16 ]. HA is used to develop influenza subunit vaccines and has been shown to induce excellent protection against influenza virus infection in addition to the H5 serotype because H5 HA is a weak antigen [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage

Kong,

He,

Wang

et al. 2023

Emerging Microbes & Infections

View full text Add to dashboard Cite

The H5N1 subtype highly pathogenic avian influenza virus (HPAIV) reveals high variability and threatens poultry production and public health. To prevent the spread of H5N1 HPAIV, we developed an H5N1 virus-like particle (VLP) vaccine based on the insect cell-baculovirus expression system. Single immunization of the H5N1 VLP vaccines induced high levels of HI antibody titres and provided effective protection against homologous virus challenge comparable to the commercial inactivated vaccine. Meanwhile, we assessed the relative efﬁcacy of different adjuvants by carrying out a head-to-head comparison of the adjuvants ISA 201 and ISA 71 and evaluated whether the two adjuvants could induce broadly protective immunity. The ISA 71 adjuvanted vaccine induced significantly higher levels of Th1 and Th2 immune responses and provided superior cross-protection against antigenically divergent H5N1 virus challenge than the ISA 201 adjuvanted vaccine. Importantly, increasing the vaccine dose could further enhance the cross-protective efficacy of H5N1 VLP vaccine and confer completely sterilizing protection against antigenically divergent H5N1 virus challenge, which was mediated by neutralizing antibodies. Our results suggest that the H5N1 VLP vaccine can provide broad-spectrum protection against divergent H5N1 influenza viruses as determined by adjuvant and vaccine dose.

show abstract

Section: Introductionmentioning

confidence: 99%

A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage

Kong,

He,

Wang

et al. 2023

Emerging Microbes & Infections

View full text Add to dashboard Cite

show abstract

“…Moreover, the efficiency of specific IgY against SARS-CoV-2 were also reported in other studies (Bao et al, 2022 ; Hakalehto, 2021 ; Lyu et al, 2021 ; Shen et al, 2021 ; Wongso et al, 2022 ). Besides these, Specific IgY antibodies also exhibited an inhibition effect against other virus infections, such as rotavirus (Skrobarczyk et al, 2022 ), influenza (Saczynska et al, 2022 ), human norovirus (Zhu et al, 2019 ), Zika virus (Magalhaes et al, 2022 ) and Ebola virus (Zhang et al, 2021 ), etc.…”

Section: Introductionmentioning

confidence: 99%

Novel extraction technologies and potential applications of egg yolk proteins

Liu

Zhang

et al. 2022

Food Sci Biotechnol

View full text Add to dashboard Cite

The high nutritional value and diverse functional properties of egg yolk proteins have led to its widespread use in the fields of food, medicine, and cosmetics. Various extraction methods have been reported to obtain the proteins from egg yolk, however, their utilization is limited due to the relatively low extraction efficiency and/or toxic solvents involved. Several simpler and greener technologies, especially physical fields (ultrasound), have been successfully developed to improve the extraction efficiency. The egg yolk proteins may exert multiple biological activities, enabling them to be a promising tool in improve human health and wellbeing, such as anti-obesity, anti-atherosclerosis, anti-osteoporosis, diagnosis and therapy for SARS-CoV-2 infections. This article summarizes the novel extraction technologies and latest applications of the egg yolk proteins in the recent 5 years, which should stimulate their utilization as health-promoting functional ingredients in foods and other commercial products.

show abstract