Chitosan-based emulgel and xerogel film containing Thymus pubescens essential oil as a potential wound dressing

Gellan-Based Hydrogel as a Drug Delivery System for Caffeic Acid Phenethyl Ester in the Treatment of Oral Candida albicans Infections

“…Drug diffusion through C. albicans biofilm is directly associated with its susceptibility to antifungal therapy, mainly due to polymeric substances of extracellular matrix [ 60 ]. Studies revealed that the concentration and release rate of compounds are important factors for their penetration on biofilms [ 61 , 62 , 63 ]. Al-Fattani and Douglas [ 61 ] analyzed the penetration of several antifungals (fluconazole, amphotericin B and voriconazole) into Candida biofilms, verifying that the drug reached the distal edges of biofilms only when it was used in concentrations substantially higher than the MIC values.…”

“…Al-Fattani and Douglas [ 61 ] analyzed the penetration of several antifungals (fluconazole, amphotericin B and voriconazole) into Candida biofilms, verifying that the drug reached the distal edges of biofilms only when it was used in concentrations substantially higher than the MIC values. Using a drug delivery system, Torabiardekani et al [ 63 ] and Karami et al [ 62 ] demonstrated that the encapsulation of essential oils in hydrogels provided their controlled and prolonged release for 270 min, which was associated with an enhanced activity against C. albicans biofilms. These results confirm that modern drug delivery systems based on hydrogels can assist by achieving better therapeutic effects with slower release process [ 13 ].…”

Chitosan/Pomegranate Seed Oil Emulgel Composition as a New Strategy for Dermal Delivery of Hydrocortisone

“…Some research papers have recently drawn attention to the use of CS as a gelling agent in emulgel compositions for the management of skin dermatitis, wound healing, and tissue regeneration [24][25][26]. To our best knowledge, there are a limited number of studies devoted to the application of CS and PO or pomegranate extract in food or cosmetic technology [27,28] and no research data focused on the use of CS and PO in the pharmaceutical technology of drug delivery systems.…”

Structure-Controllable and Mass-Produced Glycopolymersomes as a Template of the Carbohydrate@Ag Nanobiohybrid with Inherent Antibacteria and Biofilm Eradication

“…However, the overuse or even abuse of antibiotics has greatly exacerbated bacterial resistance toward almost all kinds of antibiotics, resulting in serious consequences for anti-infection treatment. − Thus, it is of extreme importance to develop new strategies for combating MDR bacteria. It is well known that bacterial infections commonly occur in biofilms in which bacterial cells are protected by extracellular polymeric substances (EPS). , Numerous human diseases are caused by biofilms. − For example, dental caries is a worldwide disease caused by the dynamic interactions of cariogenic and commensal microbes within dental plaque (biofilms) on tooth surfaces . It needs over 1000-fold common antibiotics to eradicate metabolically active bacteria in biofilms than planktonic bacteria. − Thus, from a therapeutic perspective, it is particularly significant to develop new antibacterial agents that can not only kill the MDR bacteria effectively but also disrupt the biofilms.…”