Chitosan-Based Dressing Materials for Problematic Wound Management

Park, Ji Ung; Song, Eun Ho; Jeong, Seol Ha; Song, Jiajia; Kim, Hyoun Ee; Kim, Sukwha

doi:10.1007/978-981-13-0947-2_28

Cited by 19 publications

(15 citation statements)

References 67 publications

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“…The use of chitosan as a wound dressing is well established with a number of groups using it as a wound dressing on its own or in combination with other polymers, proteins or proteoglycans [35][36][37][38][39][40][41][42][43][44]. Similarly, ECM from decellularized mammalian tissue is already used in the manufacture of several wound dressing products [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

The Antimicrobial Effectiveness and Cytotoxicity of the Antibiotic-Loaded Chitosan: ECM Scaffolds

Goller

Turner

2020

Applied Sciences

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Background: The development of multifunctional wound dressings with the ability to control hemostasis, limit infection and promote rapid wound healing and constructive tissue remodeling has been a challenge for many years. In view of these challenges, a hybrid scaffold platform was developed that combined two different extracellular matrices (ECM): ECM from decellularized mammalian tissue and ECM (chitosan) from crustaceans. Both types of ECM have well established clinical benefits that support and promote wound healing and control hemostasis. This scaffold platform could also be augmented with antibiotics to provide bactericidal activity directly to the wound site. Methods: Four different scaffold formulations were developed containing chitosan supplemented with either 20% or 50% urinary bladder matrix (UBM) hydrogel or 1% (w/v) or 10% (w/v) UBM–ECM particulates. 100% chitosan scaffolds were used as controls. The scaffolds were augmented with either minocycline or rifampicin. Escherichia Coli and Staphylococcus Aureus were used to assesses antimicrobial efficacy and duration of activity, while neutral red uptake assays were performed to establish direct and indirect cytotoxicity. Results: Results showed that scaffold handling properties, scaffold integrity over time and the efficacy and release rate of loaded antibiotics could be modified by altering scaffold composition. Moreover, antibiotics were easily released from the scaffold and could remain effective for up to 24 h by modifying the scaffold composition. Variable results with cytotoxicity testing show that further work is required to optimize the scaffold formulations but these proof of principle experiments suggest that these scaffolds have potential as bioactive wound dressings.

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Section: Discussionmentioning

confidence: 99%

The Antimicrobial Effectiveness and Cytotoxicity of the Antibiotic-Loaded Chitosan: ECM Scaffolds

Goller

Turner

2020

Applied Sciences

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“…Natural polymer-based dressings include alginate, chitosan, collagen, and cellulose. Alginate-based dressings are much better than hydrocolloid dressing due to pain controlling ability, ease to use, and exudate absorbing capacity [ 26 ]. The limitation associated with these types of dressings are associated high cost and maceration of wound [ 27 ].…”

Section: Current Wound Dressings For Dwmentioning

confidence: 99%

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Awasthi

Gulati

Kumar

et al. 2022

BioMed Research International

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Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.

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“…Deacetylation, chemical modification by adding hydrophilic biomolecules to amino or hydroxyl groups (acylation, carboxylation, alkylation, quaternization, sulfonation, and phosphorylation), crosslinking and chemical or enzymatical depolymerization or degradation are available methods for improving the solubility of chitosan and also optimizing its biological properties [ 29 , 30 ]. Because of the diverse properties of chitosan and its derivatives, they have been extensively applied in the medical and pharmaceutical fields, for example, they have been used in drug delivery [ 31 , 32 ], tissue engineering [ 20 , 33 ], wound management [ 34 , 35 ], gene and cancer therapy [ 36 , 37 , 38 ], antibiofilm drugs [ 39 ], etc.…”

Section: Structure Properties and Applications Of Chitosanmentioning

confidence: 99%

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

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Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

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Chitosan-Based Dressing Materials for Problematic Wound Management

Cited by 19 publications

References 67 publications

The Antimicrobial Effectiveness and Cytotoxicity of the Antibiotic-Loaded Chitosan: ECM Scaffolds

The Antimicrobial Effectiveness and Cytotoxicity of the Antibiotic-Loaded Chitosan: ECM Scaffolds

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

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